Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study

Terrell, Thomas R.; Abramson, Ruth; Barth, Jeffery T.; Bennett, Ellen; Cantu, Robert C.; Sloane, Richard; Laskowitz, Daniel T.; Erlanger, David; McKeag, Douglas B.; Nichols, Gregory; Valentine, Verle D.; Galloway, Leslie

doi:10.1136/bjsports-2016-097419

Cited by 23 publications

(17 citation statements)

References 76 publications

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“…One study by Terrell et al sought to explore the effect of the Asp385Ala SNP on outcome after SRC. After evaluating 1056 collegiate athletes, 133 of which suffered a SRC, the authors concluded that the Asp385Ala SNP increased risk of SRC compared to the population without this SNP [59]. These findings begin to demonstrate the complex biomolecular underpinnings of concussion and recovery and warrant further exploration.…”

Section: Future Directionsmentioning

confidence: 99%

“…This could support a theory that the lipid transport and neuromodulation after concussion in the pediatric population is different from that of adults. Another study found that having the APOE e4 allele decreased the risk of suffering a concussion in college athletes by up to 40% [59]. With the incongruities of reported data on APOE e4 concussion risk, outcome, and symptom severity, future studies should aim to investigate each of these variables in the same or more similar populations [64].…”

Section: Future Directionsmentioning

confidence: 99%

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Sport-Related Concussion: Evaluation, Treatment, and Future Directions

et al. 2019

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Sport-related concussion (SRC) is a highly prevalent injury predominantly affecting millions of youth through high school athletes every year. In recent years, SRC has received a significant amount of attention due to potential for long-term neurologic sequelae. However, the acute symptoms and possibility of prolonged recovery account for the vast majority of morbidity from SRC. Modifying factors have been identified and may allow for improved prediction of a protracted course. Potential novel modifying factors may include genetic determinants of recovery, as well as radiographic biomarkers, which represent burgeoning subfields in SRC research. Helmet design and understanding the biomechanical stressors on the brain that lead to concussion also represent active areas of research. This narrative review provides a general synopsis of SRC, including relevant definitions, current treatment paradigms, and modifying factors for recovery, in addition to novel areas of research and future directions for SRC research.

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Section: Future Directionsmentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

Sport-Related Concussion: Evaluation, Treatment, and Future Directions

et al. 2019

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“…Terrell et al [2] reported a nonsignificant observation that the MAPT rs10445337 TT genotype was weakly associated with a history of one or more concussions (odds ratio, 2.1; 95% CI, 0.3 to 14.5). Similarly, in a later study, no association was observed between concussion incidence and MAPT rs10445337 [22]. Recently, other MAPT SNPs (rs2435211 and rs2435200) have been implicated as potential pathophysiological mechanisms in RU players [20].…”

Section: Microtubule-associated Protein Tau Polymorphismsmentioning

confidence: 84%

“…However, a further step to better understanding inter-individual variability involves genetic variation and its association with concussion and related phenotypes. Evidence already exists suggesting an association between several genetic factors and inter-individual variability in traumatic brain injury incidence and severity [20][21][22][23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Genetic Factors That Could Affect Concussion Risk in Elite Rugby

Antrobus

Brazier

Stebbings

et al. 2021

Sports

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Elite rugby league and union have some of the highest reported rates of concussion (mild traumatic brain injury) in professional sport due in part to their full-contact high-velocity collision-based nature. Currently, concussions are the most commonly reported match injury during the tackle for both the ball carrier and the tackler (8–28 concussions per 1000 player match hours) and reports exist of reduced cognitive function and long-term health consequences that can end a playing career and produce continued ill health. Concussion is a complex phenotype, influenced by environmental factors and an individual’s genetic predisposition. This article reviews concussion incidence within elite rugby and addresses the biomechanics and pathophysiology of concussion and how genetic predisposition may influence incidence, severity and outcome. Associations have been reported between a variety of genetic variants and traumatic brain injury. However, little effort has been devoted to the study of genetic associations with concussion within elite rugby players. Due to a growing understanding of the molecular characteristics underpinning the pathophysiology of concussion, investigating genetic variation within elite rugby is a viable and worthy proposition. Therefore, we propose from this review that several genetic variants within or near candidate genes of interest, namely APOE, MAPT, IL6R, COMT, SLC6A4, 5-HTTLPR, DRD2, DRD4, ANKK1, BDNF and GRIN2A, warrant further study within elite rugby and other sports involving high-velocity collisions.

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“…Dretsch et al reported that soldiers carrying the brain-derived neurotrophic factor ( BDNF ) Met/Met genotype had a higher incidence of mTBI compared to non-Met/Met carriers [12]. In a prospective cohort study, interleukin-6 receptor ( IL-6R ) and apolipoprotein E ( APOE ) variants were significantly associated with the risk of concussion among 1056 college athletes [13]. A relationship between TAU variants and concussion history was also reported in rugby union players [14].…”

Section: Introductionmentioning

confidence: 99%

The functional roles of IGF-1 variants in the susceptibility and clinical outcomes of mild traumatic brain injury

Wang

Wong

et al. 2019

J Biomed Sci

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BackgroundInsulin-like growth factor 1 (IGF-1) is an important pleiotropic hormone that exerts neuroprotective and neuroreparative effects after a brain injury. However, the roles of IGF-1 variants in mild traumatic brain injury (mTBI) are not yet fully understood. This study attempted to elucidate the effects of IGF-1 variants on the risk and neuropsychiatric outcomes of mTBI.MethodsBased on 176 recruited mTBI patients and 1517 control subjects from the Taiwan Biobank project, we first compared the genotypic distributions of IGF-1 variants between the two groups. Then, we analyzed associations of IGF-1 variants with neuropsychiatric symptoms after mTBI, including anxiety, depression, dizziness, and sleep disturbances. Functional annotation of IGF-1 variants was also performed through bioinformatics databases.ResultsThe minor allele of rs7136446 was over-represented in mTBI patients compared to community-based control subjects. Patients carrying minor alleles of rs7136446 and rs972936 showed more dizziness and multiple neuropsychiatric symptoms after brain injury.ConclusionsIGF-1 variants were associated with the risk and neuropsychiatric symptoms of mTBI. The findings highlight the important role of IGF-1 in the susceptibility and clinical outcomes of mTBI.

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Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study

Abstract: CC was associated with a three times greater concussion risk and 4 with a 40% lower risk.

Cited by 23 publications

References 76 publications

Sport-Related Concussion: Evaluation, Treatment, and Future Directions

Sport-Related Concussion: Evaluation, Treatment, and Future Directions

Genetic Factors That Could Affect Concussion Risk in Elite Rugby

The functional roles of IGF-1 variants in the susceptibility and clinical outcomes of mild traumatic brain injury

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