Genetic Polymorphisms

Votinov, Mikhail; Goerlich, Katharina S.

doi:10.1002/9781119057840.ch8

Cited by 3 publications

(6 citation statements)

References 41 publications

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“…The pattern of our result is attributable at least partly to the fact that the A2 allele is associated with higher striatal D2 receptor availability. 33 Although extroversion has been associated with the hyperdopaminergic state, D2 receptor density has also been linked to neuroticism. The increased dopaminergic receptor availability and its neurophysiological effects in the striatum suggested increased task-dependent dopaminergic neurotransmission in extroverts.…”

Section: Discussionmentioning

confidence: 99%

“…The increased dopaminergic receptor availability and its neurophysiological effects in the striatum suggested increased task-dependent dopaminergic neurotransmission in extroverts. 33 , 37 , 46 It is generally assumed that those who carry the A1 allele experience a reduced sensitivity to reward as a result of a 30%–40% reduction in D2 receptor density in the striatal region compared to the A2 allele, which is well known for a hyperdopaminergic state. 45 …”

Section: Discussionmentioning

confidence: 99%

“…Compared to non-carriers, A1 allele carriers of the DRD2 Taq 1A polymorphism had lower striatal D2 receptor densities in the functional areas controlling reward, learning, addiction, and neuroticism. 33 The DRD2 Taq 1A polymorphism has been found to significantly influence reward behavior and the brain activity that underpins it. 33 The strength and longevity of these links are less clear; nonetheless, dopamine gene polymorphisms have been related to variances in personality traits in both clinical and general populations.…”

Section: Introductionmentioning

confidence: 99%

“… 33 The DRD2 Taq 1A polymorphism has been found to significantly influence reward behavior and the brain activity that underpins it. 33 The strength and longevity of these links are less clear; nonetheless, dopamine gene polymorphisms have been related to variances in personality traits in both clinical and general populations. 27 , 34 …”

Section: Introductionmentioning

confidence: 99%

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Association between dopamine receptor D2 Taq IA gene polymorphism (rs1800497) and personality traits

Olasore,

Oyedeji,

Faleti

et al. 2024

SAGE Open Medicine

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Objective: This study aimed to find a potential association between the DRD2 Taq1A gene polymorphism (rs1800497 C32806T) and personality traits. Methods: In all, 249 youths were recruited for this study. The Short-form Revised Eysenck Personality Questionnaire was administered to assess personality traits. The participants were genotyped for the DRD2 Taq1A polymorphism using the polymerase chain reaction-restriction fragment length polymorphism method. Statistical analysis was carried out to find a possible association between the genotypes and aspects of personality traits assessed. Results: The frequencies of the A1 and A2 alleles in our sampled population were 215 (43.2%) and 283 (56.8%), while the frequencies of A1A1, A1A2, and A2A2 were 67 (26.9%), 81 (32.5%), and 101 (40.6%), respectively. The study population was not in Hardy-Weinberg equilibrium ( χ2 = 17.64, p < 0.001). The A2 allele was significantly associated with extraversion. Although this allele was also associated with neuroticism, psychoticism, and lie, the association was not significant. Conclusion: The A2 allele of the DRD2 Taq1A polymorphism was found to be more associated with extraversion, as measured by the Short-form Revised Eysenck Personality Questionnaire.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between dopamine receptor D2 Taq IA gene polymorphism (rs1800497) and personality traits

Olasore,

Oyedeji,

Faleti

et al. 2024

SAGE Open Medicine

View full text Add to dashboard Cite

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“…The DRD4 gene has been associated with deficits in self‐regulation and executive functions, as well as the structural and functional integrity of brain networks related to planning and rewarding, including the prefrontal cortex (PFC), cingulate gyrus and striatum (Niitsu et al, 2018). The variations in the DRD4 gene, particularly the number of tandem repeats in exon III, significantly influence the sensitivity of dopamine receptors in the brain, thereby affecting a range of human behaviours (Votinov & Goerlich, 2021). This gene's interaction with various environmental, historical, cultural and demographic factors adds layers of complexity to its influence on social behaviours.…”

Section: Introductionmentioning

confidence: 99%

The role of the genetic influence of DRD4 in Chinese adults in the context of the choice of tourist attractions

Chen,

2024

Eur J of Neuroscience

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The aim of this work was to analyse the effect of tandem repetitions in exon III of the DRD4 gene on the features of human decision‐making in a model of choosing tourist attractions by adult residents of China. The study included 380 subjects: 162 (42.6%) men and 218 (57.4%) women. The mean age of the subjects was 31.7 ± 3.32 years. As a result of the survey of subjects, 5 groups of motivations for choosing tourist attractions were identified, and the frequency of their use, including the identified combinations, was determined. Using the genotyping method, the frequency of DRD4 subtypes among the subjects was determined, and their relationship with the indicated attraction selection groups was studied. It has been established that there is a significant dependence of the frequency of choosing the attractors ‘relaxation’, ‘desire for novelty’ and ‘self‐realization’ and their combinations on the frequency of occurrence of the DRD4 2R, 4R and 5R+ subtypes in the study groups. A conclusion was made about the possible mechanism of the influence of manifestations of DRD4 subtypes on the choice of tourist attractors by implementing the neurophysiological influence of the genome on reducing the sensitivity of brain receptors to dopamine, which stimulates behaviours that compensate for the need for additional emotional influences. This work complements the existing knowledge about the impact of human innate properties on the characteristics of his behaviour and possible patterns of influence of human genotype variability on decision‐making and suggests further possible directions of research in this area.

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Genetic predictors of interpersonal dependence

Ermakov,

Kryuchkova,

Ryagin

2023

E3S Web of Conf.

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For several decades, numerous scientific discussions about the definition and essence of the codependency phenomenon have been ongoing. At the same time, some researchers note a close relationship between this phenomenon and the concept of interpersonal dependence, considering its destructive and positive impact on personality. The relevance and value of the conducted research lies in the fact that despite numerous studies, including interdisciplinary ones, the question about the nature of interpersonal dependence remains open. The aim is to study the differences in levels of interpersonal dependence in different polymorphic variants of catechol-O-methyltransferase (COMT) and dopamine D2 receptor (DRD2) genes. An interdisciplinary molecular genetic and psychological study of 132 women with drug addiction in remission for more than two years was conducted. As a psychological tool was used, “The Interpersonal Dependency Inventory” developed by R. Hirschfield and adapted by O.P. Makushina was used. For determining the polymorphic variants of candidate genes, a method of isolating genomic DNA from buccal epithelial cells was used. The candidate genes considered were genotypes and alleles of the neurotransmitter pathways COMT and DRD2. For statistical processing of the obtained data, the nonparametric Mann-Whitney U-test was used. Substantial differences were found between the levels of interpersonal dependence in the genotypes VV and VM of the catechol-O-methyltransferase (COMT) enzyme; a trend of statistically significant differences was detected between the levels of interpersonal dependence in the genotypes CT and TT of the DRD2 gene. The features identified during the study should be taken into account in the process of carrying out psychological and preventive measures for people with addictive behaviour.

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Genetic Polymorphisms

Cited by 3 publications

References 41 publications

Association between dopamine receptor D2 Taq IA gene polymorphism (rs1800497) and personality traits

Association between dopamine receptor D2 Taq IA gene polymorphism (rs1800497) and personality traits

The role of the genetic influence of DRD4 in Chinese adults in the context of the choice of tourist attractions

Genetic predictors of interpersonal dependence

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