Genetic polymorphisms in long noncoding RNA H19 are associated with breast cancer susceptibility in Iranian population

Hassanzarei, Shekoufeh; Hashemi, Mohammad; Sattarifard, Hedieh; Bahari, Gholamreza

doi:10.1016/j.mgene.2017.07.004

Cited by 20 publications

(15 citation statements)

References 32 publications

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“…Our updated study was the largest and latest. We added another 14 recent studies including 14,347 subjects, three times as much as previous study [19,22,25,26,[28][29][30][31][32][33][34][37][38][39]. More importantly, TSA, a new method applied in our pooled analysis, evaluated the required information size of this study which was adequate to come to a reliable conclusion.…”

Section: Discussionmentioning

confidence: 99%

“…Then, we excluded totally 11 articles including 7 letters, reference abstracts and reviews and 4 articles which were not focussing on cancer susceptibility. Finally, a total of 26 eligible articles (60 studies) published from 2008 to 2019 were recruited in this meta-analysis, including 19 studies on rs217727 C > T polymorphism [19][20][21][22][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39], 13 studies on rs2839698 G > A polymorphism [19][20][21]26,27,30,31,33,34,36,38,40,41], 21 studies on rs2107425 polymorphism [27,28,[41][42][43][44][45][46] and 7 studies on rs3024270 polymorphism [20,33,34,36,[38][39][40]. The detailed characteristics and genotype distrib...…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

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Quantitative assessment of lncRNA H19 polymorphisms and cancer risk: a meta-analysis based on 48,166 subjects

Liu

Zhao

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Recently, numerous studies have been performed to detect the association between H19 polymorphisms and cancer susceptibility. However, their results were inconsistent and controversial. So, we carried out a meta-analysis aiming to define the association exactly. Eligible studies were collected using PubMed and Embase databases up to March 31, 2019. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of association. Sensitivity analysis and publication bias were established to evaluate the robustness of our results. Totally, 60 studies involving 20763 cases and 27403 patients were analysed in our meta-analysis. Our results indicated that H19 rs217727 C > T polymorphism was significantly associated with increased cancer risk. In subgroup analysis, similarly increased risk could be found in gastrointestinal group for rs2839698 and protective effect was observed in rs2107425 polymorphism for cancer development in Caucasian population. Trial sequential analysis strengthened findings of our meta-analysis that cumulative evidence was adequate. In summary, our meta-analysis supported that H19 polymorphisms may be associated with cancer susceptibility.

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Section: Discussionmentioning

confidence: 99%

Section: Characteristics Of Studiesmentioning

confidence: 99%

Quantitative assessment of lncRNA H19 polymorphisms and cancer risk: a meta-analysis based on 48,166 subjects

Liu

Zhao

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…A study conducted by Yang et al revealed that the TT + CT genotype of rs2839698 could increase the risk of hepatocellular cancer [31]. In terms of H19 rs217727, it was found to increase the risk of breast cancer [12, 13, 15]. Further functional experiments found that the expression level of H19 in breast cancer tissues was higher than that in normal tissues, and rs217727 CT or TT genotype was helpful to improve the expression level of H19 (P<0.001, 12].…”

Section: Discussionmentioning

confidence: 99%

Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis

et al. 2019

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BackgroundWe have performed this study to evaluate the association between H19 rs217727 polymorphism and the risk of cancer.MethodsAn odds ratio (OR) with a 95% confidence interval (CI) was applied to determine a potential association.ResultsA total of 17 case–control publications were selected. This meta-analysis showed that H19 rs217727 has a significant increased association with cancer risk in allelic, homozygous, heterozygote, dominant and recessive models (T vs C: OR = 1.16, 95% CI = 1.06–1.27, I2 = 75.7; TT vs CC: OR = 1.29, 95% CI = 1.06–1.56, I2 = 71.6; CT vs CC: OR = 1.15, 95% CI = 1.01–1.31, I2 = 75.4; CT + TT vs CC: OR = 1.20, 95% CI = 1.05–1.36, I2 = 76.5; TT vs CT + CC: OR = 1.22, 95% CI = 1.02–1.45, I2 = 70.6;). In the subgroup analysis of smoking status, both smokers and nonsmokers showed an increase in cancer risk in allelic, homozygous, dominant and heterozygote models.ConclusionThis meta-analysis revealed H19 rs217727 may influence cancer susceptibility.

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“…Hassanzarei et al, in case‐control study was performed on 230 BC patients and 240 ages adjusted healthy women with no history of any cancer in Southeast Iranian population. The findings revealed an association between lncRNA‐H19 gene polymorphism and BC risk.…”

Section: Discussionmentioning

confidence: 99%

Association of the study between LncRNA‐H19 gene polymorphisms with the risk of breast cancer

Abdollahzadeh

Ghorbian

2018

Clinical Laboratory Analysis

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Background The H19 is a maternally expressed imprinted gene transcribing a long noncoding RNA (lncRNA), which has previously been reported to be involved in tumorigenesis and cancer progression. The aim of this study was to evaluate the associations between two lncRNA‐H19 (rs3741219 T>C and rs217727 C>T) gene polymorphisms with the risk of breast cancer (BC). Methods In a case‐control investigation, we evaluated 150 BC patients and 100 cancer‐free subjects in East Azerbaijan Province of Iran. To assess two gene polymorphisms, the polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) method was used. Results The genotype frequencies of two lncRNA‐H19 (rs217727 C>T and rs3741219 T>C) gene polymorphisms TT + TC/CC and CC + CT/TT have not shown a statistically significant association with the risk of BC (P = 0.065; OR = 0.967; 95% CI, 0.938‐0.996) and (P = 0.510; OR = 1.583; 95% CI, 0.399‐6.726), respectively. In addition, our findings revealed a significant differences in allele frequencies in lncRNA‐H19 rs217727 C>T polymorphism between groups (P = 0.033; OR = 1.985; 95% CI, 1.048‐3.761). Conclusion Our findings suggested that rs217727 C>T polymorphism may be involved in the pathogenesis of BC, whereas rs3741219 T>C variation may not be involved in the genetic background of BC in Iranian.

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Genetic polymorphisms in long noncoding RNA H19 are associated with breast cancer susceptibility in Iranian population

Cited by 20 publications

References 32 publications

Quantitative assessment of lncRNA H19 polymorphisms and cancer risk: a meta-analysis based on 48,166 subjects

Quantitative assessment of lncRNA H19 polymorphisms and cancer risk: a meta-analysis based on 48,166 subjects

Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis

Association of the study between LncRNA‐H19 gene polymorphisms with the risk of breast cancer

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