Genetic polymorphisms in MMP 2, 9 and 3genes modify lung cancer risk and survival

González-Arriaga, Patricia; Pascual, Teresa; García-Álvarez, Arturo; Fernández-Somoano, Ana; López-Cima, María Felicitas; Tardón, Adonina

doi:10.1186/1471-2407-12-121

Cited by 69 publications

(63 citation statements)

References 34 publications

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“…Many studies have investigated the role of MMP-2 polymorphisms in lung cancer risk, but have yielded inconsistent and inconclusive results (Yu et al, 2002;Zhou et al, 2005;Rollin et al, 2007;Song et al, 2007;Aysegul et al, 2011;Gonzalez-Arriaga et al, 2012). Meta-analysis is a quantitative approach in which individual study findings on the same topic are statistically integrated and analyzed, and recently, it has been used for the evaluation of cancer prognostic markers and genetic risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…After discarding those which clearly did not meet the criteria and excluding 19 records, 7 full-text publications with a total of 3,189 lung cancer cases and 3,013 controls were included into this meta-analysis (Yu et al, 2002;Zhou et al, 2005;Rollin et al, 2007;Song et al, 2007;Jia, 2009;Aysegul et al, 2011;Gonzalez-Arriaga et al, 2012). Ethnic groups among these studies were as following: 3 from Caucasians and 4 from Asians.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Ethnic groups among these studies were as following: 3 from Caucasians and 4 from Asians. There were 4 studies with a total of 2,045 cases and 1913 controls on MMP-2 C735T polymorphism (Zhou et al, 2005;Rollin et al, 2007;Jia, 2009;Gonzalez-Arriaga et al, 2012), and there were 5 studies with a total of 2,004 cases and 1967 controls on MMP-2 C1306T polymorphism (Yu et al, 2002;Zhou et al, 2005;Rollin et al, 2007;Song et al, 2007;Aysegul et al, 2011). The number of cases varied from 89 to 816, with a mean of 456, and the numbers of controls varied from 90 to 852, with a mean of 430.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Quantitative Assessment of the Effects of MMP-2 Polymorphisms on Lung Carcinoma Risk

Guo

Wang²,

Zhang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: Previous studies assessing associations between matrix metalloproteinase 2 (MMP-2) polymorphisms and lung cancer risk reported conflicting results. A meta-analysis was therefore performed to derive a more precise estimation. Method: Case-control studies assessing associations between MMP-2 C735T and C1306T polymorphisms and lung cancer risk were included. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. Results: 7 studies with a total of 3,189 lung cancer cases and 3,013 controls were finally included into this meta-analysis. Overall, the MMP-2 C735T polymorphism was associated with lung cancer risk under the homozygote model (CC versus TT: OR =1.44, 95% CI = 1.03-2.02, I 2 = 0%), while the MMP-2 C1306T polymorphism also associated demonstrated links with all four models (all P values less than 0.05). Subgroup analyses by race suggested obvious associations between MMP-2 C735T and C1306T polymorphisms and lung cancer risk in Asians but not in Caucasians. There was no evidence for publication bias. Conclusion: Currently available evidence supports teh conclusion that MMP-2 C735T and C1306T polymorphisms influence susceptibility to lung cancer in Asians.

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Section: Discussionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative Assessment of the Effects of MMP-2 Polymorphisms on Lung Carcinoma Risk

Guo

Wang²,

Zhang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

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“…42 The enzymatic activity and expression of MMP-2 were examined using gelatin zymography and western blotting assays, respectively ( Figure 6). When both cell lines were treated with either SQE or CIS, lower levels of MMP-2 enzymatic activity were detected, along with reduced levels of MMP-2 expression.…”

Section: Combination Of Sqe and Cis Suppresses The Metastatic Potentimentioning

confidence: 99%

Combination of Sasa quelpaertensis Nakai Leaf Extract and Cisplatin Suppresses the Cancer Stemness and Invasion of Human Lung Cancer Cells

Kim

et al. 2014

Integr Cancer Ther

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Lung cancer is the leading cause of cancer death worldwide, and most chemotherapeutic drugs have limited success in treating this disease. Furthermore, some drugs show undesirable side effects due to the enrichment of cancer stem cells (CSCs) that are present, leading to resistance to conventional chemotherapy and tumor relapse. CSCs possess self-renewal characteristics, aggressive tumor initiating activity, and ability to facilitate tumor metastasis. Therefore, development of nontoxic agents that can potentiate chemotherapy and eliminate CSCs would be highly desirable. In the present study, we investigated whether Sasa quelpaertensis leaf extracts (SQE) and cisplatin (CIS), individually or in combination, would exert anti-CSC and antimetastatic effect in H1299 and A549 human lung cancer cells. Following these treatments, cell growth, phosphorylation of phosphoinositide-3 kinase, and activation of the mammalian target of rapamycin were inhibited. Decreased serial sphere formation, clonogenicity, and expression of major stem cell markers, such as CD44 and SOX-2, in CD44 + cancer stem cells were also observed. In addition, inhibition of cell migration and invasion in both cell lines as well as inhibition of matrix metalloproteinase-2 activity and expression were detected. Importantly, the anticancer stemness and antimetastasis effects in each of these assays were greater for the combined treatment with SQE and CIS than with each treatment individually. In conclusion, the data suggest that SQE alone, or in combination with CIS, represents a promising therapeutic strategy for eliminating cancer stemness and cell invasion potential of CSCs, thereby treating and preventing metastatic lung cancer cells.

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“…Matrix metalloproteinases (MMPs) are a family of zinc-dependent protease enzymes that degrade and restructure the extracellular matrix (ECM) components and basal lamina which are physical barriers for cancer cells [6,7,8]. MMPs have a broad substrate activity including the ECM components of collagen type I-VIII, gelatin, elastin, laminin, and also myelin basic protein and several growth factors.…”

Section: Introductionmentioning

confidence: 99%

MMP-7 A-181G Polymorphism in Breast Cancer Patients from Western Iran

et al. 2015

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Background: Matrix metalloproteinases (MMPs) are upregulated in tumors. The MMP-7 A-181G polymorphism is associated with increased expression of the MMP-7 gene. Aim of the present study was to investigate the association between the MMP-7 A-181G polymorphism and susceptibility to breast cancer. Patients and Methods: The MMP-7 A-181G variants were studied in a cohort of 251 subjects consisting of 100 breast cancer patients and 151 healthy controls; all were from Western Iran. The MMP-7 A-181G genotypes were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequencies of the MMP-7 AA, AG, and GG genotypes in healthy individuals were 34.4, 50.4, and 15.2%, respectively. In breast cancer patients, the frequencies of AA (34%), AG (52%), and GG (14%) genotypes (p = 0.95) were similar to those in the controls. There was a trend toward an increased frequency of the combined genotype of MMP-7 AG+GG in patients with lymph node metastasis (70.4%) compared to those without metastasis (66.7%). Also, in patients with invasive lobular carcinoma, the frequency of the MMP-7 AG+GG genotype tended to be higher (71.4%) compared to that in patients with invasive ductal carcinoma (66.2%) (p = 0.78). Conclusion: Our findings indicate that the MMP-7 A-181G polymorphism may not be correlated with susceptibility to breast cancer in our population.

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Genetic polymorphisms in MMP 2, 9 and 3genes modify lung cancer risk and survival

Cited by 69 publications

References 34 publications

Quantitative Assessment of the Effects of MMP-2 Polymorphisms on Lung Carcinoma Risk

Quantitative Assessment of the Effects of MMP-2 Polymorphisms on Lung Carcinoma Risk

Combination of Sasa quelpaertensis Nakai Leaf Extract and Cisplatin Suppresses the Cancer Stemness and Invasion of Human Lung Cancer Cells

MMP-7 A-181G Polymorphism in Breast Cancer Patients from Western Iran

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