Genetic Polymorphisms in Monoamine Neurotransmitter Systems Show Only Weak Association with Acute Post-Surgical Pain in Humans

Kim, Hyungsuk; Lee, Hyewon; Rowan, Janet S.; Brahim, Jaime S.; Dionne, Raymond A.

doi:10.1186/1744-8069-2-24

Cited by 109 publications

(103 citation statements)

References 43 publications

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“…We selected the COMT gene because of its high priority candidate rating (Belfer et al, 2004) and its previous influence on pain perception for healthy subjects (Zubieta et al, 2003;Diatchenko et al, 2005Diatchenko et al, , 2006. The influence of COMT genotype for clinically relevant phenotypes has been questioned in the literature (Kim et al, 2006), but our data suggested that COMT diplotype had an influence on pain ratings, at least when determined by LPS and APS/HPS groups.…”

Section: Discussionmentioning

confidence: 57%

“…This assertion was confirmed in healthy volunteers as μ-opioid receptor binding potential and activation were predictably associated with a COMT gene single nucleotide polymorphism (SNP) at codon 158 (Zubieta et al, 2003) and experimental pain sensitivity was associated with COMT haplotypes (Diatchenko et al, 2005. In contrast, other studies have found no association with COMT genotype and pain sensitivity in healthy volunteers (Kim et al, 2004) or weak associations in a post-surgical pain model (Kim et al, 2006).…”

Section: Introductionmentioning

confidence: 60%

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Evidence for a biopsychosocial influence on shoulder pain: Pain catastrophizing and catechol- O -methyltransferase (COMT) diplotype predict clinical pain ratings

George

Wallace

Wright

et al. 2008

Pain

151

128

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The experience of pain is believed to be influenced by social, cultural, environmental, psychological, and genetic factors. Despite this assertion, few studies have included clinically relevant pain phenotypes when investigating interactions among these variables. This study investigated whether psychological variables specific to fear-avoidance models and catechol-O-methyltransferase (COMT) genotype influenced pain ratings for a cohort of patients receiving operative treatment of shoulder pain. Patients (n = 58) completed questionnaires and had COMT genotype determined preoperatively. Then, shoulder pain ratings were collected 3-5 months post-operatively. This cohort consisted of 24 females and 34 males, with mean age of 50.3 (SD = 15.0) and pre-operative pain rating of 4.5/10 (SD = 1.8). The frequency of COMT diplotypes was 34 with "high COMT activity" (LPS group) and 24 with "low COMT activity" (APS/HPS group). Preliminary analysis indicated that of all the fear-avoidance variables considered (fear of pain, kinesiophobia, pain catastrophizing, and anxiety), only pain catastrophizing was a unique contributor to clinical pain ratings. A hierarchical regression model indicated that an interaction between pain catastrophizing and COMT diplotype contributed additional variance in pre-operative pain ratings. The pain catastrophizing × COMT diplotype interaction demonstrated predictive validity as patients with high pain catastrophizing and low COMT activity (APS/HPS group) were more likely (RR = 6.8, 95% CI = 2.8-16.7) to have post-operative pain ratings of 4.0/10 or higher. Our findings suggest that an interaction between pain catastrophizing and COMT diplotype has the potential to influence pain ratings in patients seeking operative treatment of their shoulder pain.

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Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 60%

Evidence for a biopsychosocial influence on shoulder pain: Pain catastrophizing and catechol- O -methyltransferase (COMT) diplotype predict clinical pain ratings

George

Wallace

Wright

et al. 2008

Pain

151

128

View full text Add to dashboard Cite

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“…47 We considered COMT genotype in this study because of its high-priority candidate rating 11 and its previous influence on pain perception for healthy participants, 13-15 and also those seeking surgical treatment for shoulder pain. 2 We did not detect a main effect for COMT genotype in the current study, however, our primary hypothesis did not involve testing main effects of COMT genotype.…”

Section: Discussionmentioning

confidence: 99%

Biopsychosocial Influence on Exercise-induced Delayed Onset Muscle Soreness at the Shoulder: Pain Catastrophizing and Catechol-O-Methyltransferase (COMT) Diplotype Predict Pain Ratings

George

Dover²,

Wallace

et al. 2008

The Clinical Journal of Pain

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Objective-The experience of pain is believed to be influenced by psychologic and genetic factors. A previous study suggested pain catastrophizing and catechol-O-methyltransferase (COMT) genotype influenced clinical pain ratings for patients seeking operative treatment of shoulder pain. This study investigated whether these same psychologic and genetic factors predicted responses to induced shoulder pain.Methods-Participants (n=63) completed self-report questionnaires and had COMT genotype determined before performing a standardized fatigue protocol to induce delayed onset muscle soreness. Then, shoulder pain ratings, self-report of upper-extremity disability ratings, and muscle torque production were reassessed 24, 48, and 72 hours later.Results-This cohort consisted of 35 women and 28 men, with a mean age of 20.9 years (SD=1.7). The frequency of COMT diplotypes was 42 with "high COMT enzyme activity" (low pain sensitivity group) and 21 with "low COMT enzyme activity" (average pain sensitivity/high pain sensitivity group). A hierarchical regression model indicated that an interaction between pain catastrophizing and COMT diplotype was the strongest unique predictor of 72-hour pain ratings. The same interaction was not predictive of self-report of disability or muscle torque production at 72 hours. The pain catastrophizing × COMT diplotype interaction indicated that participants with high pain catastrophizing and low COMT enzyme activity (average pain sensitivity/high pain sensitivity group) were more likely (relative risk=3.5, P=0.025) to have elevated pain intensity ratings (40/100 or higher).Reprints: Steven Z. George, PT, PhD, Department of Physical Therapy, Brooks Center for Rehabilitation Studies, University of Florida, Health Science Center, PO Box 100154, Gainesville, FL 32610-0154 (e-mail: E-mail: szgeorge@phhp.ufl.edu). NIH Public Access Author ManuscriptClin J Pain. Author manuscript; available in PMC 2009 April 16. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptDiscussion-These findings from an experimental model converge with those from a surgical cohort and provide additional evidence that the presence of elevated pain catastrophizing and COMT diplotype indicative of low COMT enzyme activity have the potential to increase the risk of developing chronic pain syndromes.Keywords biopsychosocial model; chronic pain; catastrophizing; COMT genotype; shoulder pain; delayed onset muscle sorenessThe experience of pain varies considerably among individuals. Social, cultural, environmental, psychologic, and genetic factors are all believed to contribute to this variability. A model for the development of idiopathic pain conditions that takes into consideration these sources of variability was recently proposed. 1 In this model, it is suggested that high levels of psychologic distress and pain amplification (ie, genetic predisposition for biologic or physiologic processes) are the primary factors contributing to the development of idiopathic pain conditions. 1Few studies to da...

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“…2). [20][21][22][23][24][25][26] However, not all the evidence from these gene-pain studies concurs, 27 and it is therefore premature to use gene-mapping to predict and treat pain conditions.…”

Section: Agementioning

confidence: 99%

Pain following the repair of an abdominal hernia

2009

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Pain and other types of discomfort are frequent symptoms following the repair of an abdominal hernia. After 1 year, the incidence of light to moderate pain following inguinal hernia repair is as high as 10% and 2% for severe disabling chronic pain. Postoperative chronic pain not only affects the individual patient, but may also have a great impact on relatives and society, and may be a cause of concern for the responsible surgeon. This paper provides an overview of the anatomy, surgical procedures, and disposing factors (age, gender, ethnicity, genotype, previous hernia repair, pain prior to surgery, psychosocial characteristics, and surgical procedures) related to the postoperative pain conditions. Furthermore, the mechanisms for both acute and chronic pain are presented. We focus on inguinal hernia repair, which is the most frequent type of abdominal hernia surgery that leads to chronic pain. Finally, the paper provides an update on the diagnostic and treatment routines for postoperative pain.

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Genetic Polymorphisms in Monoamine Neurotransmitter Systems Show Only Weak Association with Acute Post-Surgical Pain in Humans

Cited by 109 publications

References 43 publications

Evidence for a biopsychosocial influence on shoulder pain: Pain catastrophizing and catechol- O -methyltransferase (COMT) diplotype predict clinical pain ratings

Evidence for a biopsychosocial influence on shoulder pain: Pain catastrophizing and catechol- O -methyltransferase (COMT) diplotype predict clinical pain ratings

Biopsychosocial Influence on Exercise-induced Delayed Onset Muscle Soreness at the Shoulder: Pain Catastrophizing and Catechol-O-Methyltransferase (COMT) Diplotype Predict Pain Ratings

Pain following the repair of an abdominal hernia

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