Genetic polymorphisms in toll-like receptors 1, 2, and 4 in feline upper respiratory tract aspergillosis

Whitney, Joanna; Haase, Bianca; Beatty, Julia A.; Barrs, Vanessa R.

doi:10.1016/j.vetimm.2019.109921

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…Although many PRRs have been described as participating in anti- Sporothrix response in humans and mice, we do not know which receptors and associated pathways are involved in the recognition of Sporothrix PAMPs by feline neutrophils or peripheral blood mononuclear cells (PBMCs). Toll-like receptors (TLRs) were described to be involved in the response to Aspergillus and Microsporum in cats [ 9 , 29 , 30 ]. However, it is noteworthy that, unlike Sporothrix , these fungal species typically generate hyphae in the host.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil Oxidative Burst Profile Is Related to a Satisfactory Response to Itraconazole and Clinical Cure in Feline Sporotrichosis

de Miranda,

Santiago,

Frankenfeld

et al. 2024

JoF

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Despite the central role of cats in the transmission and amplification of Sporothrix, studies regarding immune response in feline sporotrichosis are scarce. In cats with sporotrichosis, neutrophil-rich lesions are usually associated to good general condition and lower fungal burden. However, the role of neutrophils in anti-Sporothrix immunity has been little explored in cats. Thus, the aim of this study was to evaluate the neutrophil oxidative burst in the blood of cats with sporotrichosis. Cats with sporotrichosis included in the study were treated with itraconazole (ITZ) alone or combined with potassium iodide (KI). The neutrophil oxidative burst was evaluated through a flow-cytometry-based assay using dihydrorhodamine 123 (background) and stimulation with Zymosan and heat-killed Sporothrix yeasts. The cure rate was 50.0% in cats under treatment with ITZ monotherapy and 90.9% in cats treated with ITZ + KI (p = 0.014), endorsing the combination therapy as an excellent alternative for the treatment of feline sporotrichosis. Higher percentages of Sporothrix-stimulated neutrophils were associated with good general condition (p = 0.003). Higher percentages of Sporothrix- (p = 0.05) and Zymosan-activated (p = 0.014) neutrophils before and early in the treatment were related to clinical cure in ITZ-treated cats. The correlation between oxidative burst and successful use of KI could not be properly assessed given the low number of failures (n = 2) in this treatment group. Nasal mucosa involvement, typically linked to treatment failure, was related to lower percentages of activated neutrophils in the background at the treatment outcome (p = 0.02). Our results suggest a beneficial role of neutrophils in feline sporotrichosis and a positive correlation between neutrophil activation and the cure process in ITZ-treated cats.

show abstract

Section: Discussionmentioning

confidence: 99%

Neutrophil Oxidative Burst Profile Is Related to a Satisfactory Response to Itraconazole and Clinical Cure in Feline Sporotrichosis

de Miranda,

Santiago,

Frankenfeld

et al. 2024

JoF

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show abstract

“…There has been very limited veterinary research to investigate putative immunological defects. The findings from one study did not support a role for single-nucleotide polymorphisms (SNPs) in the coding regions of pattern recognition receptor genes, specifically Toll-like receptor (TLR) genes 1, 2 and 4, in the pathogenesis of fungal rhinosinusitis caused by Aspergillus species in cats [ 8 ] .…”

Section: Full-textmentioning

confidence: 99%

Comments on Case Report: A fatal case of Aspergillus felis infection in an immunocompetent host

Barrs

2023

Access Microbiology

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Innate immunity in cats

Tizard

2025

The Immunology of the Cat

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Genetic polymorphisms in toll-like receptors 1, 2, and 4 in feline upper respiratory tract aspergillosis

Cited by 6 publications

References 34 publications

Neutrophil Oxidative Burst Profile Is Related to a Satisfactory Response to Itraconazole and Clinical Cure in Feline Sporotrichosis

Neutrophil Oxidative Burst Profile Is Related to a Satisfactory Response to Itraconazole and Clinical Cure in Feline Sporotrichosis

Comments on Case Report: A fatal case of Aspergillus felis infection in an immunocompetent host

Innate immunity in cats

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