Genetic Polymorphisms of Angiotensinogen and Essential Hypertension in a Tibetan Population

Niu, Wenquan; Qi, Yue; Cen, Weijun; Cui, Chaoying; Zhuoma, Ciren; Cai, Dan; Zhou, Wu-qing; Qiu, Changchun

doi:10.1291/hypres.30.1129

Cited by 25 publications

(26 citation statements)

References 44 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…68,69 Empirical studies with both simulated and real data indicate that as an analytical data-mining method, MDR has good power for identifying high-order gene-gene interactions. 40,41 Strong to moderate synergism observed between -6G>A, M235T and -217G>A polymorphisms in the present study is in contrast to studies from Tibetan and Han Chinese populations who showed a strong synergistic effect between -6G>A and -20A>C 26,58 leading to EHT.…”

Section: Discussioncontrasting

confidence: 95%

Estimation of risk and interaction of single nucleotide polymorphisms at angiotensinogen locus causing susceptibility to essential hypertension: a case control study

Charita

Gunda

Sushma

et al. 2012

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

Introduction:The risk conferred by the variants and haplotypes of single nucleotide polymorphisms (SNPs) at human angiotensinogen (AGT) gene to essential hypertension (EHT) have been described in several populations with variations in the results attributed to their ethnicity. We attempted to evaluate the risk of -217G>A, -152G>A, -20A>C, -6G>A, T174M, M235T and 15241A>G polymorphisms at AGT locus along with the analyses of haplotype and epistatic interactions in causing susceptibility to EHT. Method: Two-hundred and forty-nine hypertensives and 248 controls were genotyped for the selected markers. Results: Study of demographic parameters revealed significant association of obesity, positive family history and nonvegetarian diet habit, suggesting elevated risk of the condition when associated with these parameters. Significantly high risk for males with AA genotype of -217G>A polymorphism was observed for developing EHT (p = .07). Males with -217A (p = .01) showed a two-fold higher risk for EHT. Markers -217G>A and -6G>A were in strong linkage disequilibrium in patients as compared to controls. Strong epistatic interactions were found between -6G>A, M235T and -217G>A markers, supporting the synergistic effect between them leading to EHT. Conclusion: Our findings suggest that -217A variant is significantly associated with the risk for EHT in males. Further studies on the functional role of the marker -217 are recommended for understanding the cause of association with EHT. KeywordsEssential hypertension (EHT), angiotensinogen (AGT), linkage disequilibrium (LD), multifactor dimensionality reduction (MDR), single nucleotide polymorphism (SNP), haplotype association, epistatic interaction, statistical package for social sciences (SPSS)

show abstract

Section: Discussioncontrasting

confidence: 95%

Estimation of risk and interaction of single nucleotide polymorphisms at angiotensinogen locus causing susceptibility to essential hypertension: a case control study

Charita

Gunda

Sushma

et al. 2012

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

show abstract

“…Investigation is limited to genes of known function that have been related to the pathophysiology of the disease in question. As an example, many candidate gene studies have been conducted in patients with cardiovascular diseases, including hypertension and heart failure based on the known importance of the renin-angiotensin-aldosterone axis and the adrenergic receptor system [58][59][60][61][62][63][64]. Candidate gene studies have often produced conflicting results in hypertension and in limited studies of patients with heart failure.…”

Section: Candidate Genomicsmentioning

confidence: 99%

Systems biology and heart failure: concepts, methods, and potential research applications

Adams

2009

Heart Fail Rev

View full text Add to dashboard Cite

Dramatic advances in molecular biology dominated twentieth century biomedical science and delineated the function of individual genes and molecules in exquisite detail. However, biological processes cannot be fully understood based on the properties of individual genes and molecules alone, since these elements act in concert to enable the specific functions that make for living cells and organisms. The discipline of systems biology provides a novel conceptual framework for understanding biological phenomenon. Systems biology synthesizes information concerning the interactions of genes and molecules and allows characterization of the supramolecular networks and functional modules that represent the most essential aspects of cell organization and physiology.

show abstract

“…Ten publications were included in the final meta-analysis (Ishigami et al, 1997;Wang et al, 1999;Sato et al, 2000;Tsai et al, 2003;Velez et al, 2006;Niu et al, 2007;Qi et al, 2008;Jiang et al, 2009;Ying et al, 2010;Li et al, 2013) based on the above-mentioned inclusion and exclusion criteria. Details of the selection process are presented in the flow chart in Figure 1.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…All studies utilized blood samples for genotyping. The HWE test was performed on genotype distribution of the controls; all were high-quality studies, excluding those conducted by Sato et al (2000), Tsai et al (2003), and Niu et al (2007). …”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Association of A-20C polymorphism in the angiotensinogen gene with essential hypertension: a meta-analysis

Zeng¹,

Wang²,

Fang³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The A-20C polymorphism in the angiotensinogen (AGT) gene has been associated with increased risk of essential hyper tension in several studies; however, these studies gave inconsistent results. In this study, we performed a meta-analysis to assess the association between AGT A-20C polymorphism and essential hyper tension. Published literature was retrieved from PubMed. Pooled odd's ratio (OR) with 95% confidence interval (CI) was calculated using fixed-or random-effect models. A total of 10 case-control studies containing 3653 cases and 3457 controls were enrolled to this meta-analysis. In a combined analysis, the results showed a significant association between the AGT A-20C polymorphism and risk of essential hyper tension (AA vs CC: OR = 0.62, 95%CI = 0.46-0.84; recessive model: OR = 0.66, 95%CI = 0.49-0.88). In the subgroup analysis

show abstract

Genetic Polymorphisms of Angiotensinogen and Essential Hypertension in a Tibetan Population

Cited by 25 publications

References 44 publications

Estimation of risk and interaction of single nucleotide polymorphisms at angiotensinogen locus causing susceptibility to essential hypertension: a case control study

Estimation of risk and interaction of single nucleotide polymorphisms at angiotensinogen locus causing susceptibility to essential hypertension: a case control study

Systems biology and heart failure: concepts, methods, and potential research applications

Association of A-20C polymorphism in the angiotensinogen gene with essential hypertension: a meta-analysis

Contact Info

Product

Resources

About