Genetic polymorphisms of complement components C6 and C7 in Korean

Abstract

SummaryGenetic polymorphisms of the complement components C6 and C7 were investigated in Korean living in Seoul using isoelectric focusing and immunoblotting. Three common and four rare C6 allotypes were observed. The allele frequencies estimated were as follows: C6*A 0.433, C6*B 0.523, C6"B2 0.039, and rare alleles (M91, M92, M11 and M2) 0.005. Three C7 variants, besides a common allele, were observed with polymorphic frequencies. Two rare C7 variants, considered to be new, were also observed. The allele frequencies estimated for C7"1, C7"2, C7"3, C7"4, and rare variants (tentatively named K1 and K2) were 0.843, 0.073, 0.034, 0.048 and 0.002, respectively. The C6 and C7 allele frequencies are similar to those in Japanese and Chinese. The association analysis between C6 and C7 showed a significant negative association between C6 B and C7 4 allotypes (p < 0.02).

Survey of seven plasma protein polymorphisms in the Amhara and Oromo populations of Ethiopia

“…Both are monomorphic in Caucasians and polymorphic in Blacks, though to different extents (Hobart et al, 1978;Park et al, 1988;Sepehrnia et al, 1988a,b;Corbo et al, 1994). The two Ethiopian populations do not show any variation at these two loci.…”

C7 Reference Typing and Nomenclature Recommendations

“…It seems to be generally agreed that Oriental populations have both a higher frequency of variants (i.e. heterozygosity rate) and a greater variety of variants than Caucasian populations [2][3][4][5][6][7][8][9][10][11].…”

The Cayapa Indians of Ecuador: A Genetically Isolated Group With Unexpected Complement C7 M/N Allele Frequencies

“…Moreover, complete absence of the C6*B2 allele was noted; this allele is present in all Oriental populations examined. Interestingly, the Cayapas presented with another allele instead, C6*A21 (at a frequency of 0.055 ;Scacchi et al, 1994), which was reported to be extremely rare or absent in Oriental populations, such as Japanese, Chinese or Korean (Tokunaga et al, 1986;Zeng et al, 1986;Park et al, 1988). A further difference from other Oriental populations was that only the common C7 1 phenotype was observed (Scacchi etal., 1994).…”