Genetic polymorphisms of CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 in Vietnamese-Koreans

Lim, Y.-J.; Cha, Eun-Young; Jung, Hwa Jin; Ghim, Jong-Lyul; Lee, Su-Jun; Kim, Eun Young; Shin, Jae‐Gook

doi:10.12793/tcp.2014.22.2.70

Cited by 7 publications

(2 citation statements)

References 35 publications

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“…This study was significant in that it scientifically suggested that zaltoprofen pharmacokinetic differences between CYP2C9*1/*1 and *1/*3 were small and that it is not essential to consider the genotype of CYP2C9 for clinical applications. This was predicted when considering the proportion of *3/*3 in the total population, which is approximately 1–2% [ 21 ], and the differences in pharmacokinetics in *1/*3 are proportional (although the pharmacokinetics of zaltoprofen for CYP2C9*3/*3 have not been confirmed experimentally).…”

Section: Discussionmentioning

confidence: 99%

Population Pharmacokinetic Modeling of Zaltoprofen in Healthy Adults: Exploring the Dosage Regimen

2023

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Zaltoprofen is a drug used for various pain and inflammatory diseases. Scientific and quantitative dosage regimen studies regarding its clinical application are scarce. This study aimed to discover effective covariates related to interindividual pharmacokinetic variability through population pharmacokinetic modeling for zaltoprofen and to explore dosage regimens. The bioequivalence results of healthy Korean males, biochemical analysis, and CYP2C9 genotyping information were utilized in modeling. The established model has been sufficiently verified through a bootstrap, goodness-of-fit, visual predictive check, and normalized prediction distribution error. External data sets derived from the literature were used for further model validation. The final model could be used to verify the dosage regimen through multiple exposure simulations according to the numerical change of the selected covariates. Zaltoprofen pharmacokinetics could be explained by a two-compartment with a first-order absorption model. Creatinine clearance (CrCL) and albumin were identified as effective covariates related to interindividual zaltoprofen pharmacokinetic variability, and they had positive and negative correlations with clearance (CL/F), respectively. The differences in pharmacokinetics between individuals according to CYP2C9 genetic polymorphisms (*1/*1 and *1/*3) were not significant or valid covariates. The model simulation confirmed that zaltoprofen pharmacokinetics could significantly differ as the CrCL and albumin levels changed within the normal range. Steady-state plasma exposure to zaltoprofen was significantly reduced in the group with CrCL and albumin levels of 130 mL/min and 3.5 g/dL, respectively, suggesting that dose adjustment may be necessary. This study is useful to guide precision medicine of zaltoprofen and provides scientific quantitative judgment data for its clinical applications.

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Section: Discussionmentioning

confidence: 99%

Population Pharmacokinetic Modeling of Zaltoprofen in Healthy Adults: Exploring the Dosage Regimen

2023

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“…Cycling was performed using the GeneAmp PCR system 9700 (Applied Biosystems, Foster City, CA, USA) and standard methods. 12 SNaPshot Multiplex Kit (Applied Biosystems, CA, USA) was used for single nucleotide polymorphism (SNP) genotyping. Then samples were analyzed using an ABI-Prism 3130 genetic analyzer (Applied Biosystems, CA, USA).…”

Section: Genotypingmentioning

confidence: 99%

The Algorithm with Multiple Genotypes on Optimal Warfarin Doses in Korean Patients

Li¹,

Kim²,

Han³

et al. 2020

Clin Exp Thromb Hemost

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Population pharmacokinetic analysis of lornoxicam in healthy Korean males considering creatinine clearance and CYP2C9 genetic polymorphism

Jeong

Jang

Lee

2021

J. Pharm. Investig.

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Genetic polymorphisms of CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 in Vietnamese-Koreans

Cited by 7 publications

References 35 publications

Population Pharmacokinetic Modeling of Zaltoprofen in Healthy Adults: Exploring the Dosage Regimen

Population Pharmacokinetic Modeling of Zaltoprofen in Healthy Adults: Exploring the Dosage Regimen

The Algorithm with Multiple Genotypes on Optimal Warfarin Doses in Korean Patients

Population pharmacokinetic analysis of lornoxicam in healthy Korean males considering creatinine clearance and CYP2C9 genetic polymorphism

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