Genetic polymorphisms of FADS1, FADS2, and FADS3 and fatty acid profiles in subjects received methadone maintenance therapy

Yang, Hui; Wang, Ruey Yun; Huang, Shih‐Yi; Huang, Chieh-Liang; Su, Kuan‐Pin

doi:10.1016/j.plefa.2017.01.006

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…We used eQTL single nucleotide polymorphisms from each of the 335 meta-analysis significantly enriched genes and found one significant colocalization between the DEG FADS1 and sleep duration (posterior probability H4 = 0.0196). FADS1 has been linked to neuropsychiatric disorders and sleep, which could be linked to the orexin receptor pathway (but not enriched in the pathway) (52).…”

Section: Resultsmentioning

confidence: 99%

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Identifying novel gene dysregulation associated with opioid overdose death: A meta-analysis of differential gene expression in human prefrontal cortex

Carter,

Quach,

Willis

et al. 2024

Preprint

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Only recently have human postmortem brain studies of differential gene expression (DGE) associated with opioid overdose death (OOD) been published; sample sizes from these studies have been modest (N = 40-153). To increase statistical power to identify OOD-associated genes, we leveraged human prefrontal cortex RNAseq data from four independent OOD studies and conducted a transcriptome-wide DGE meta-analysis (N = 285). Using a unified gene expression data processing and analysis framework across studies, we meta-analyzed 20 098 genes and found 335 significant differentially expressed genes (DEGs) by OOD status (false discovery rate < 0.05). Of these, 66 DEGs were among the list of 303 genes reported as OOD-associated in prior prefrontal cortex molecular studies, including genes/gene families (e.g., OPRK1, NPAS4, DUSP, EGR). The remaining 269 DEGs were not previously reported (e.g., NR4A2, SYT1, HCRTR2, BDNF). There was little evidence of genetic drivers for the observed differences in gene expression between opioid addiction cases and controls. Enrichment analyses for the DEGs across molecular pathway and biological process databases highlight an interconnected set of genes and pathways from orexin and tyrosine kinase receptors through MEK/ERK/MAPK signaling to affect neuronal plasticity.

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Section: Resultsmentioning

confidence: 99%

“…FADS1 has been linked to neuropsychiatric disorders and sleep, which could be linked to the orexin receptor pathway (but not enriched in the pathway) (52).…”

Section: Colocalization Analysis Of Differential Expressed Gene and G...mentioning

confidence: 99%

Identifying novel gene dysregulation associated with opioid overdose death: A meta-analysis of differential gene expression in human prefrontal cortex

Carter,

Quach,

Willis

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…We infer that n-3 PUFA might be related to the protein expression level of the FADS gene cluster, and future studies need to verify our inference. There were no associations between FADS3 gene expression and PUFA in breast milk in our study, and the function of the FADS3 gene in relation to PUFA synthesis needs to be addressed in future studies [ 47 , 48 ].…”

Section: Discussionmentioning

confidence: 95%

Association between FADS Gene Expression and Polyunsaturated Fatty Acids in Breast Milk

Tian

Lin

et al. 2022

Nutrients

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Polyunsaturated fatty acid (PUFA) in breast milk provides physiological benefits for offspring and is closely related to endogenous biosynthesis in lactating women. Few studies have addressed the association between fatty acid desaturase (FADS) gene expression patterns and fatty acids in breast milk. This research aimed to explore the differences in PUFA levels among breast milk groups with different levels of FADS gene expression and provide a scientific basis for precision nutrition strategies. A total of 50 healthy women 42–45 days postpartum were included in this study. A basic information questionnaire and breast milk samples were collected. Eight types of PUFA were detected, and RNA was extracted from breast milk. The transcription level of the FADS gene was detected using real-time quantitative PCR. Significant differences in the content of gamma-linolenic acid and eicosatrienoic acid (C20:3n6) were found in breast milk among FADS1 gene transcription groups (p = 0.009, p = 0.042, respectively). No significant differences in PUFA were found among the FADS2 and FADS3 gene expression groups. The results demonstrated that n-6 PUFA was associated with the mRNA expression levels of the FADS1 gene. They are of great significance in developing new methods and diets to optimize infant feeding using breast milk.

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Comprehensive genetic study of fatty acids helps explain the role of noncoding inflammatory bowel disease associated SNPs and fatty acid metabolism in disease pathogenesis

Jezernik

Potočnik

2018

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Genetic polymorphisms of FADS1, FADS2, and FADS3 and fatty acid profiles in subjects received methadone maintenance therapy

Cited by 5 publications

References 37 publications

Identifying novel gene dysregulation associated with opioid overdose death: A meta-analysis of differential gene expression in human prefrontal cortex

Identifying novel gene dysregulation associated with opioid overdose death: A meta-analysis of differential gene expression in human prefrontal cortex

Association between FADS Gene Expression and Polyunsaturated Fatty Acids in Breast Milk

Comprehensive genetic study of fatty acids helps explain the role of noncoding inflammatory bowel disease associated SNPs and fatty acid metabolism in disease pathogenesis

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