Genetic Polymorphisms of Glutathione<i>S</i>-Transferases and the Risk of Adult Brain Tumors: A Meta-analysis

Lai, Rose; Crevier, Louis; Thabane, Lehana

doi:10.1158/1055-9965.epi-05-0105

Cited by 71 publications

(53 citation statements)

References 32 publications

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“…In that meta-analysis, the authors searched publications up to January 2005, and found no significant association between GSTM1 and GSTT1 polymorphisms and risk of glioma. In contrast, some of our findings were in disagreement with the results reported by Lai et al who found that the GSTT1 null genotype was significantly associated with an increased risk of meningioma (OR =1.95; 95% CI, 1.02-3.76, P = 0.046) (Lai et al, 2005). The main reason for this discrepancy may be that the statistical power is not sufficient to provide accurate effect of GSTT1 polymorphism on the risk of meningioma.…”

Section: Discussioncontrasting

confidence: 99%

“…Taken together, we may conclude that GSTM1 and GSTT1 homozygous deletion polymorphisms may not relate to the development of brain tumors. Some of our findings were similar to the results of a meta-analysis presented by Lai et al in 2005(Lai et al, 2005. In that meta-analysis, the authors searched publications up to January 2005, and found no significant association between GSTM1 and GSTT1 polymorphisms and risk of glioma.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Lack of Association Between GSTM1 and GSTT1 Polymorphisms and Brain Tumour Risk

Sima

Zhong²,

Liu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: Glutathione S-transferases (GSTs) are important enzymes that are involved in detoxification of environmental carcinogens. Molecular epidemiological studies have been conducted to investigate the association between GSTM1 and GSTT1 homozygous deletion polymorphisms and brain tumours but results have been conflicting. The aim of this study was to clarify this problem using a meta-analysis. Methods: A total of 9 records were identified by searching the PubMed and Embase databases. Fixed-and random-effects models were performed to estimate the pooled odds ratios. Results: No significant association was found between the GSTM1 and GSTT1 homozygous deletion polymorphisms and risk of brain tumours, including glioma and meningioma. Similar negative results were also observed in both population-based and hospital-based studies. Conclusion: These findings indicate that the GSTM1 and GSTT1 polymorphisms may not be related to the development of brain tumours.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 90%

Lack of Association Between GSTM1 and GSTT1 Polymorphisms and Brain Tumour Risk

Sima

Zhong²,

Liu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…A meta-analysis of eight studies with 1,630 gliomas, 245 meningiomas, and 7,151 controls found no association between glutathione S-transferases (GST) variants and adult brain tumors. 84 Neural carcinogens, such as dietary N-nitroso compounds (NOCs) from consumption of cured meats, were studied for the risk of gliomas. A pooled analysis of nine population-based studies failed to establish NOCs as a causal agent for glioma.…”

Section: Pbts Molecular Epidemiologic Studies With Focus On Metabolismmentioning

confidence: 99%

Molecular Epidemiology of Primary Brain Tumors

Liu

Kyritsis

et al. 2009

Neurotherapeutics

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Summary:Although primary brain tumors (PBTs) are generally considered to be a multifactorial disorder, understanding the genetic basis and etiology of the disease is essential for PBT risk assessment. Understanding of the genetic susceptibility for PBT has come from studies of rare genetic syndromes, linkage analysis, family aggregation, early-onset pediatric cases, and mutagen sensitivity. There are currently no effective markers to assess biological dose of exposures and genetic heterogeneity. The priorities recently recommended by the Brain Tumor Epidemiology Consortium emphasized the need for expanding research in genetics and molecular epidemiology. In this article, we review the literature to identify molecular epidemiologic case-control studies of PBTs that were hypothesis-driven and focused on four hypothesized candidate pathways: DNA repair, cell cycle, metabolism, and inflammation. We summarize the results in terms of genetic associations of single nucleotide polymorphisms of these pathways. We also discuss future research directions based on available evidence and technologies, and conclude that high resolution whole genome approach with significantly large sample size could rapidly advance our understanding of the genetic etiology of PBTs. Literature searches were done on PubMed in March 2009 with the terms glioma, glioblastoma, brain tumor, association, and polymorphism, and we only reviewed English language publications.

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“…In contrast, Lai et al (2005) conducted a meta-analysis of the association between genetic polymorphisms of GSTs and the risk of adult brain tumors (Lai et al, 2005), and their results did not suggest any relationship between those two. Additionally, several large-sample, case-control studies that have been conducted by various authors around the world have reported conflicting results after previous meta-analysis.…”

Section: An Updated Pooled Analysis Of Glutathione S-transferase Genomentioning

confidence: 98%

“…Because GSTs are important in the cellular detoxification of carcinogens, genetic variants of GSTs have been studied extensively in relation to cancer risk. A search of the literature prior to June 2011 revealed thousands of studies regarding the relationship between GST genotypes and breast (Bailey et al, 1998), lung (Zheng et al, 2006, colon (Zhong et al, 1993), brain (Lai et al, 2005), bladder (Hung et al, 2004), prostate (Ntais et al, 2005) and other types of cancer (Gao et al, 2011). These studies have primarily focused on single nucleotide polymorphisms (SNPs) in GSTM1, GSTT1, and GSTP1.…”

Section: An Updated Pooled Analysis Of Glutathione S-transferase Genomentioning

confidence: 99%

An Updated Pooled Analysis of Glutathione S-transferase Genotype Polymorphisms and Risk of Adult Gliomas

Yao¹,

Ji²,

Gu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: Glutathione S-transferases (GSTs) are multifunctional enzymes that play a crucial role in the detoxification of both the endogenous products of oxidative stress and exogenous carcinogens. Recent studies investigating the association between genetic polymorphisms in GSTs and the risk of adult brain tumors have reported conflicting results. The rationale of this pooled analysis was to determine whether the presence of a GST variant increases adult glioma susceptibility by combining data from multiple studies. Methods: In our meta-analysis, 12 studies were identified by a search of the MEDLINE, HIGHWIRE, SCIENCEDIRECT and EMBASE databases. Of those 12, 11 evaluated GSTM1, nine evaluated GSTT1 and seven evaluated GSTP1 Ile105Val. Between-study heterogeneity was assessed using χ 2 -based Q statistic and the I 2 statistic. Crude odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to estimate the association between GSTM1, GSTT1 and GSTP1 polymorphisms and the risk of adult gliomas. Results: The quantitative synthesis showed no significant evidence to indicate an association exists between the presence of a GSTM1, GSTT1 or GSTP1 Ile105Val haplotype polymorphism and the risk of adult gliomas (OR, 1.008, 1.246, 1.061 respectively; 95% CI, 0.901-1.129, 0.963-1.611, 0.653-1.724 respectively). Conclusions: Overall, this study did not suggest any strong relationship between GST variants or related enzyme polymorphisms and an increased risk of adult gliomas. Some caveats include absence of specific raw information on ethnic groups or smoking history on glioma cases in published articles; therefore, well-designed studies with a clear stratified analysis on potential confounding factors are needed to confirm these results.

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Genetic Polymorphisms of GlutathioneS-Transferases and the Risk of Adult Brain Tumors: A Meta-analysis

Cited by 71 publications

References 32 publications

Lack of Association Between GSTM1 and GSTT1 Polymorphisms and Brain Tumour Risk

Lack of Association Between GSTM1 and GSTT1 Polymorphisms and Brain Tumour Risk

Molecular Epidemiology of Primary Brain Tumors

An Updated Pooled Analysis of Glutathione S-transferase Genotype Polymorphisms and Risk of Adult Gliomas

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