Genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and alterations of sex hormones in filling-station workers

Expression Levels of Some Detoxification Genes in Liver and Testis of Rats Exposed to a Single Dose of Methyl-Tertiary Butyl Ether

“…It should be noted that in filling station workers, which were occupationally exposed to gasoline, alteration in serum testosterone was significantly modulated by the GSTT1 and GSTM1 polymorphisms [ 1 , 16 ]. Also, it has been reported that the GSTT1 and GSTM1 polymorphisms may modulate the alterations in several end organ markers (such as liver function indies, sex hormones, etc) in persons exposed to natural sour gas [ 17 - 23 ].…”

“…It has been reported that serum testosterone significantly decreased in male gasoline filling station workers [ 1 ]. Methyl-tertiary-butyl ether (MTBE), a well known oxygenated compound which has been used to improve air quality by reducing environmental pollutants, is still used in several Middle East countries.…”

“…Very recently it has been reported that exposure to MTBE was associated with alteration in serum testosterone in experimental rats [ 7 ]. It should be noted that the above-mentioned alteration in serum testosterone of filling station workers has been associated with genetic polymorphisms of GSTT1 and GSTM1 [ 1 , 16 ]. Also, it has been reported by our research group that the alterations of end organ markers in residences of Masjid-i-Sulaiman (Khuzestan province, southwest Iran) who are living in contaminating areas and in gasoline filling station workers, were modulated by the genetic polymorphisms of GSTT1 and GSTM1 [ 17 - 23 ].…”

Evaluation of offspring sex ratio, sex hormones and antioxidant enzymes following exposure to methyl tertiary butyl ether in adult male Sprague-dawley rats

“…But the other possible mechanism may be the role of genetic factors in the host response to toxic environmental exposures. Such a mechanism was suggested in a previous study who indicated that decrease in testosterone level in male gasoline filling station workers was most pronounced in the group with the glutathione S-transferase T1 ( GSTT1 ) null genotype compared with the group possessing the GSTT1 genotype (Saadat and Monzavi, 2008[ 19 ]). Therefore, the observed alterations in sex hormones following MTBE exposure merit further evaluation via investigating the genetic background of the host in future research.…”