Genetic polymorphisms of GSTP1 and mEPHX correlate with oxidative stress markers and lung function in COPD

Vibhuti, Arpana; Arif, Ehtesham; Deepak, Desh; Singh, B.; Pasha, M. A. Qadar

doi:10.1016/j.bbrc.2007.05.076

Cited by 54 publications

(56 citation statements)

References 28 publications

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“…[2,7,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]) investigating the EPHX1 T113C and A139G polymorphisms in relation to COPD or emphysema as the primary end-point were included. Two minor studies were excluded from the analyses, because we were unable to retrieve the original papers despite contacting the corresponding authors.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…They do not find any effect on the risk of COPD for either the T113C or the A139G polymorphisms. [13] HERSH [28] FU [27] BRØGGER [2] CHENG [26] PARK [25] ZIDZIK [24] VIBHUTI [23] MATHESON [22] KORYTINA [20] BUDHI [19] RODRIGUEZ [18] XIAO [17] TAKEYABU [16] YIM [15] PARK [14] SMITH [21] CHAPPELL [7] Overall . Meta-analysis of EPHX1 A139G genotype and risk of chronic obstructive pulmonary disease (COPD); overall and stratified analyses using both random and fixed effect models.…”

Section: Copdmentioning

confidence: 99%

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EPHX1polymorphisms, COPD and asthma in 47,000 individuals and in meta-analysis

Lee¹,

Nordestgaard²,

Dahl³

2010

Eur Respir J

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We tested the hypothesis that two well-characterised functional polymorphisms of the microsomal epoxide hydrolase gene (EPHX1), T113C and A139G, may influence susceptibility to chronic obstructive pulmonary disease (COPD) and asthma.We genotyped participants from the Copenhagen City Heart Study (n510,038) and the Copenhagen General Population Study (n537,022) for the T113C and A139G variants in the EPHX1 gene and measured lung function and recorded COPD hospitalisation and asthma and smoking history. Finally, we meta-analysed results from 19 studies including 7,489 COPD cases and 42,970 controls.The OR for spirometry-defined COPD or COPD hospitalisation did not differ from 1.0 for any of the EPHX1 genotypes or phenotypes overall, or in smokers or nonsmokers separately (p-value for trend 0.18-0.91). Likewise, EPHX1 genotypes or phenotypes did not associate with risk of asthma (p-value for trend 0.46-0.98). In meta-analysis, random effects OR for COPD in T113C heterozygotes and homozygotes versus non-carriers were 1.17 (0.99-1.38) and 1.38 (1.09-1.74), respectively. Corresponding values for A139G were 0.93 (0.83-1.05) and 0.89 (0.78-1.02).Our results indicate that genetically reduced microsomal epoxide hydrolase activity is not a major risk factor for COPD or asthma in the Danish population; however, meta-analysis cannot completely exclude a minor effect on COPD risk.

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Section: Statistical Analysesmentioning

confidence: 99%

Section: Copdmentioning

confidence: 99%

EPHX1polymorphisms, COPD and asthma in 47,000 individuals and in meta-analysis

Lee¹,

Nordestgaard²,

Dahl³

2010

Eur Respir J

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“…Although the physical function of SERPINE2 in COPD and emphysema has not yet been fully resolved, it is suggested that SERPINE2 may play an important role in the pathogenesis of COPD. For another COPD-related gene GSTP1, it has been reported that 105V/114V alleles of GSTP1 are associated with imbalanced oxidative stress and lung function in patients (Vibhuti et al, 2007). Similarly, DeMeo et al (2007) concluded that the apical-predominant emphysematous destruction is influenced by polymorphisms in the xenophobic enzymes of GSTP1.…”

Section: Discussionmentioning

confidence: 98%

“…Recently, a series of studies have implicated that COPD represents a complex disease with genetics contributions from multiple genes. For example, Vibhuti et al (2007) approved that 113H/139H alleles of mEPHX and 105V/114V alleles of GSTP1 and the combination of genotypes with same alleles are associated with imbalanced oxidative stress and lung function in COPD patients. A genome-wide linkage analysis in the Boston Early-Onset COPD study suggested that SERPINE2 may be associated with the COPD-related phenotypes (Palmer et al, 2003;Silverman et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

A bioinformatics strategy for detecting the complexity of Chronic Obstructive Pulmonary Disease in Northern Chinese Han Population

Hua

et al. 2012

Genes Genet. Syst.

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Chronic Obstructive Pulmonary Disease (COPD) is a complex human disease which is driven not only by genetic factors, but also by various environmental variables, such as gender, age and smoking. Therefore, there is a demand for investigating the complexity among various risk factors involved in COPD. In this study, 44 tagging SNPs from EPHX1, GSTP1, SERPINE2 and TGFB1 were selected and genotyped in 310 COPD cases and 203 controls, all of which belong to the Han from North China. We integrated functional prediction algorithms of nonsynonymous SNPs (nsSNPs) into Bayesian network to explore the complex regulatory relationships among disease traits and various risk factors. The results showed that three basic variables (age, sex and smoking) were risk factors of COPD-related trait and phenotype. Besides these environmental risk factors, deleterious nsSNPs were found to perform better than those of significant synonymous SNPs when used as variables to make risk prediction of disease outcome. This study provides further evidences for detecting the complexity of COPD in Northern Chinese Han Population.

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“…Το wt αλληλόµορφο (Ile105) συσχετίστηκε µε την ανάπτυξη της νόσου σε Ιάπωνες [85], την κατ' εξοχήν εντόπι-ση του εµφυσήµατος στους άνω λοβούς µεταξύ ασθενών µε διαπιστωµένο εµφύσηµα [82], και σε οµοζυγωτία µε την ταχεία έκπτωση της αναπνευστικής λειτουργίας σε άτοµα µε οικο-γενειακό ιστορικό νόσου [86]. Αντίθετα, σε Ινδούς διαπιστώθηκε ότι τα αλλήλια 105V και 114V, καθώς και ο απλότυπος 105V/114V εµφανίζονταν συχνότερα µεταξύ των ασθενών µε ΧΑΠ συγκριτικά µε υγιείς µάρτυρες [77]. Ωστόσο, δεν υπήρξε επαναληψιµότητα των αποτε-λεσµάτων σε µελέτες σε Κορεάτες [87] και σε Κινέζους [88,74].…”

Section: πανγενωµικές µελέτεςunclassified

Πολυμορφισμοί Των TLR2 Και TLR4 Στη Χρόνια Αποφρακτική Πνευμονοπάθεια

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Genetic polymorphisms of GSTP1 and mEPHX correlate with oxidative stress markers and lung function in COPD

Cited by 54 publications

References 28 publications

EPHX1polymorphisms, COPD and asthma in 47,000 individuals and in meta-analysis

EPHX1polymorphisms, COPD and asthma in 47,000 individuals and in meta-analysis

A bioinformatics strategy for detecting the complexity of Chronic Obstructive Pulmonary Disease in Northern Chinese Han Population

Πολυμορφισμοί Των TLR2 Και TLR4 Στη Χρόνια Αποφρακτική Πνευμονοπάθεια

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