Genetic polymorphisms of IL-10, IL-18 and IL12B are associated with risk of non-small cell lung cancer in a Chinese Han population

Zhang, Wei; Dang, Shengqiang; Zhang, Guangjian; He, Haiqi; Wen, Xiaopeng

doi:10.1016/j.intimp.2019.105938

Cited by 10 publications

(16 citation statements)

References 35 publications

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“…The Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is involved in immune function, cell growth, differentiation, and hematopoiesis, among other physiological processes. , Elevated IL-6/JAK/STAT3 signaling has been reported to be among the key pathways involved in colorectum tumorigenesis; this signaling plays a critical role in colorectal cancer (CRC) initiation, development, and formation, with increased IL-6 production being observed in tumor tissue, as well as in the serum of CRC patients. , IL-6 signal transduction leads to the activation of JAK, which in turn activates the transcription factor STAT3 …”

Section: Il-6 Signaling Mechanismmentioning

confidence: 99%

“…60,61 Elevated IL-6/ JAK/STAT3 signaling has been reported to be among the key pathways involved in colorectum tumorigenesis; this signaling plays a critical role in colorectal cancer (CRC) initiation, development, and formation, with increased IL-6 production being observed in tumor tissue, as well as in the serum of CRC patients. 62,63 IL-6 signal transduction leads to the activation of JAK, which in turn activates the transcription factor STAT3. 64 When activated by upstream signaling pathways, such as JAK, epidermal growth factor receptor, and IL-6R, STAT3 is phosphorylated and forms dimers with other members of the STAT family.…”

Section: Il-6 Signaling Mechanismmentioning

confidence: 99%

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Perspective for Discovery of Small Molecule IL-6 Inhibitors through Study of Structure–Activity Relationships and Molecular Docking

Nada

Sivaraman

et al. 2023

J. Med. Chem.

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) is a proinflammatory cytokine that plays a key role in the pathogenesis and physiology of inflammatory and autoimmune diseases, such as coronary heart disease, cancer, Alzheimer's disease, asthma, rheumatoid arthritis, and most recently COVID-19. IL-6 and its signaling pathway are promising targets in the treatment of inflammatory and autoimmune diseases. Although, anti-IL-6 monoclonal antibodies are currently being used in clinics, huge unmet medical needs remain because of the high cost, administration-related toxicity, lack of opportunity for oral dosing, and potential immunogenicity of monoclonal antibody therapy. Furthermore, nonresponse or loss of response to monoclonal antibody therapy has been reported, which increases the importance of optimizing drug therapy with small molecule drugs. This work aims to provide a perspective for the discovery of novel small molecule IL-6 inhibitors by the analysis of the structure−activity relationships and computational studies for protein−protein inhibitors targeting the IL-6/IL-6 receptor/gp130 complex.

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Section: Il-6 Signaling Mechanismmentioning

confidence: 99%

Section: Il-6 Signaling Mechanismmentioning

confidence: 99%

Perspective for Discovery of Small Molecule IL-6 Inhibitors through Study of Structure–Activity Relationships and Molecular Docking

Nada

Sivaraman

et al. 2023

J. Med. Chem.

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“…The inflammatory reaction involves complex mechanisms accompanied by the production of pro‐inflammatory cytokines and inflammatory mediators such as tumor necrosis factor, nitric oxide (NO). Inflammation is closely related to the pathogenesis of chronic diseases such as antibiotic associated diarrhea, inflammatory bowel disease, cancer [1–3] . Macrophages are related immune cells that play important roles in the process of inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…Inflammation is closely related to the pathogenesis of chronic diseases such as antibiotic associated diarrhea, inflammatory bowel disease, cancer. [1][2][3] Macrophages are related immune cells that play important roles in the process of inflammation. Macrophages can be stimu-lated by LPS to activate the toll-like receptor 4 signaling pathway, which promotes the expression of a variety of inflammatory factors.…”

Section: Introductionmentioning

confidence: 99%

Isolation, Structural Analysis and Anti‐Inflammatory Activity of a Polysaccharide from Ilex cornuta Fruits

Cui

Tian

Sun

et al. 2022

Chemistry & Biodiversity

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In the present study, a polysaccharide from Ilex cornuta fruits (LCFP‐3) was obtained by hot water extraction, Diethyaminoethyl cellulose‐52 (DEAE‐52) chromatography column and Sephadex G‐100 gel column purification. Its structural characteristics were further explored using high performance anion exchange chromatography (HPAEC), gas chromatography and mass spectrometry (GC/MS), scanning electron microscopy (SEM), Fourier transform infrared (FT‐IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy. Monosaccharide composition analysis revealed LCFP‐3 contained mainly Galactose (31.92 %), Arabinose (25.87 %) and Galacturonic acid (23.35 %) while small percentage of Rhamnose, Glucose, Mannose and Xylose. Chemical composition analysis showed that the total sugar content of LCFP‐3 was 90.31 % and the protein content was 0.246 %. Gel permeation chromatography (GPC) analysis showed that its average molecular weight was 41.199 kDa. Structural analysis showed that LCFP‐3 may be composed of residues, T‐α‐Arap, T‐α‐Rhap, 1,3‐α‐Arap, 1,4‐α‐Arap, T‐β‐Galp, 1,4‐α‐GalpA(OMe), 1,4‐β‐Glcp, 1,3‐β‐Galp, 1,3,6‐β‐Manp, 1,6‐β‐Galp, 1,3,4‐β‐GalpA, 1,4,6‐β‐Manp, 1,3,6‐β‐Glcp, 1,2,3,4‐α‐Xylp. The anti‐inflammatory activity of LCFP‐3 was evaluated using lipopolysaccharide (LPS)‐induced RAW246.7 macrophages. The results showed that 1–200 μg/mL LCFP‐3 could dose‐dependently protect against LPS‐induced toxicity and 1 μg/mL LCFP‐3 could significantly inhibit LPS‐induced NO production. Therefore, LCFP‐3 exerted an anti‐inflammatory activity and has great potential as a functional ingredient.

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“…IL-18 possesses strong immunomodulatory biological activity, exerts anti-infection, antiparasite and antitumor effects by inducing interferon-γ (13), promotes perforin-and FasL-mediated cytotoxicity, and directly or indirectly inhibits and destroys malignant tumors via multiple channels (14). Thus, IL-18 inhibits or prevents the growth of breast cancer, bladder cancer and neuroblastoma (15,16). According to a…”

Section: Introductionmentioning

confidence: 99%

Interleukin‑18 and ‑10 may be associated with lymph node metastasis in breast cancer

Ma¹,

Kong

2021

Oncol Lett

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Reports on the expression of interleukin (IL)-10 in breast cancer are rare. The present study investigated the correlation between IL-18 and −10 in breast cancer, and assessed their clinical significance. Breast cancer (n=104) and breast fibroadenoma (n=31) tissues that were surgically removed and pathologically confirmed at Jinan Central Hospital Affiliated to Shandong University (Jinan, China) between November 2016 and January 2019 were collected. The expression of IL-18 and −10 was observed via immunohistochemistry. Breast cancer tissues were positive for IL-18 expression, which was primarily located in the cell membrane and cytoplasm. A significant difference in IL-18 expression was observed between breast cancer and fibroadenoma tissues (75.0 vs. 19.4%; P<0.001). IL-10 was expressed in breast cancer tissues and primarily located in the cytoplasm. Breast cancer tissues showed a significantly higher level of IL-10 expression compared with breast fibroadenoma tissues (78.8 vs. 22.6%; P<0.001). The regions of positive IL-18 and −10 expression were consistent. Tissues with positive expression of IL-18 and/or −10 had a significantly higher rate of lymph node metastasis than those with negative expression (IL-18: 67.9 vs. 42.3%; P=0.035; and IL-10: 67.1 vs. 40.9%; P=0.047). In conclusion, IL-18 is highly expressed in breast cancer and correlates positively with IL-10. Both IL-18 and −10 may correlate positively with lymph node metastasis in breast cancer.

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Genetic polymorphisms of IL-10, IL-18 and IL12B are associated with risk of non-small cell lung cancer in a Chinese Han population

Cited by 10 publications

References 35 publications

Perspective for Discovery of Small Molecule IL-6 Inhibitors through Study of Structure–Activity Relationships and Molecular Docking

Perspective for Discovery of Small Molecule IL-6 Inhibitors through Study of Structure–Activity Relationships and Molecular Docking

Isolation, Structural Analysis and Anti‐Inflammatory Activity of a Polysaccharide from Ilex cornuta Fruits

Interleukin‑18 and ‑10 may be associated with lymph node metastasis in breast cancer

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