Genetic polymorphisms of IL-27 and risk of systemic lupus erythematosus disease in the Egyptian population

Ali, Yasser B.M.; El-Akhras, Basima A.; El-Shazly, Reem; Bassyouni, Iman H.

doi:10.1007/s10067-021-05858-6

Cited by 7 publications

(9 citation statements)

References 27 publications

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“…This comes consistent with previous studies carried out among Egyptian patients where musculoskeletal (arthritis), mucocutaneous (rash), and LN were the most common phenotypes. 4,6 The present study demonstrated a significant association between HLA-G 3ˊUTR polymorphisms (HLA-G ins/del rs371194629), previously suggested to have functional significance, 17 with SLE susceptibility for the first time among Egyptian patients. A significant over-presentation of the HLA-G ins allele has been observed in SLE patients versus healthy subjects with a significant difference in the frequency of ins/ins genotype among both groups (P < 0.001, OR = 11.79) highlighting it as a potential risk factor for SLE development among those patients.…”

Section: Discussionsupporting

confidence: 55%

“…This comes consistent with previous studies carried out among Egyptian patients where musculoskeletal (arthritis), mucocutaneous (rash), and LN were the most common phenotypes. 4 , 6 …”

Section: Discussionmentioning

confidence: 99%

“…3 Among Egyptian patients, different genetic polymorphisms have been studied and found to be associated with SLE as polymorphisms in the gene coding for the autoimmune regulator (AIRE), type I interferon (IFN) pathway, interleukin 27, programmed cell death 1 (PD1), tumor necrosis factor (TNF-α) and IFN-γ. [4][5][6][7][8] However, the role of the human leukocyte antigen-G (HLA-G) gene has not been addressed before among Egyptian patients.…”

Section: Introductionmentioning

confidence: 99%

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Immunogenetic Relationship of HLA-G 14 bp Insertion/Deletion Polymorphism and Toll-Like Receptor 9 with Systemic Lupus Erythematosus in Egyptian Patients: A Case-Control Study

Mohammed¹,

Kady²,

Boghdadi³

et al. 2022

IJGM

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Introduction The level of expression of the immunoregulatory human leukocyte antigen-G (HLA-G) has been suggested to play a role in the immunopathogenesis of systemic lupus erythematosus (SLE). A 14 bp insertion/deletion (ins/del) polymorphism in the 3ˊuntranslated region of HLA-G gene may influence the level of expression. The role of Toll-like receptor 9 (TLR9) in the pathogenesis of SLE has been highlighted. Data among Egyptian patients are quite limited. Purpose To detect the association of HLA-G 14 bp ins/del gene polymorphism with the susceptibility to SLE and to correlate TLR9 serum level with disease activity among Egyptian patients. Patients and Methods A case-control study that included 102 SLE female patients and 102 healthy matched volunteers as controls was carried out. Disease activity in patients was determined using the modified Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). HLA-G 14 bp ins/del genotype was detected by polymerase chain reaction (PCR). TLR9 serum level was estimated using enzyme-linked immunosorbent assay (ELISA) technique. Results The ins/ins genotype was significantly increased among SLE patients compared to healthy subjects (58.8% vs 9.8%; odds ratio [OR] = 11.79, P < 0.001). The 14 bp ins allele was significantly more frequent in SLE patients than in healthy subjects (65.7% vs 27.9%, respectively) and significantly associated with an increased risk of SLE (OR 4.94, P < 0.001). The mean TLR9 serum level showed a significant increase in SLE patients compared to healthy subjects (397.04±137.86 vs 195.22±45.14 ng/L, p < 0.001) and was significantly associated with disease activity as well as to patients’ HLA-G genotypes (p < 0.001). Conclusion Among Egyptian population, HLA-G 14 bp ins/ins homozygous genotype and ins allele may constitute a potential risk for SLE susceptibility, while TLR9 serum level is significantly associated with disease activity.

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Section: Discussionsupporting

confidence: 55%

“…This comes consistent with previous studies carried out among Egyptian patients where musculoskeletal (arthritis), mucocutaneous (rash), and LN were the most common phenotypes. 4 , 6 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Immunogenetic Relationship of HLA-G 14 bp Insertion/Deletion Polymorphism and Toll-Like Receptor 9 with Systemic Lupus Erythematosus in Egyptian Patients: A Case-Control Study

Mohammed¹,

Kady²,

Boghdadi³

et al. 2022

IJGM

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“… 25 Th17 cells are an effector CD4+ T cell subset characterized by the secretion of IL IL‐17A. 26 It has different functional characteristics from the traditional T cell subsets Th1 and Th2 cells. Th17 cells are a proinflammatory subgroup of Th cells and play a crucial role in the pathogenesis of autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

“…A large number of studies have shown that autoantibodies produced by disordered B cells, abnormal expression and function of T cells, and cytokines secreted by abnormal T cells are all involved in the pathogenesis of SLE 25 . Th17 cells are an effector CD4+ T cell subset characterized by the secretion of IL IL‐17A 26 . It has different functional characteristics from the traditional T cell subsets Th1 and Th2 cells.…”

Section: Discussionmentioning

confidence: 99%

Effects of Astragalus membranaceus on systemic lupus erythematosus in a mouse model of pregnancy

Chen

Zhang²,

Li³

et al. 2022

Immunity Inflam & Disease

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Background This study used astragalus membranaceus (AM) to treat systemic lupus erythematosus (SLE) model mice during pregnancy, aiming to explore the role of AM in Helper T cell 17 (Th17) differentiation and SLE during pregnancy. Methods We used lipopolysaccharide to constructed the SLE mouse model. AM decoction given by intragastric administration lasted from the eighth week of the mouse age until the mouse was killed. We estimated the messenger RNA levels of IL‐17a and Rorc, counted the Th17 cell number and examined the levels of cytokines including interleukin (IL)‐12, tumor necrosis factor α, interferon gamma, IL‐17A in mouse serum. Periodic acid‐Schiff staining and renal glomerular/tubulointerstitial (TI) score were used to evaluate the progression of lupus nephritis (LN). Results AM treatment improved the conception rate and increased the number and average weight of fetuses in SLE mice. It significantly decreased the urinary albumin/creatinine ratios and reduced the glomerular scores and TI scores in the pregnant SLE mice. AM gavage significantly decreased the weight of spleen, mesenteric lymph node, total splenocytes and T cells, and the expression of proinflammatory factors. Furthermore, AM treatment reduced the ratio of Th17 cells and the expression levels of RORγt and IL‐17A. Conclusion AM significantly improved pregnancy outcomes and inhibited lupus nephritis during pregnancy in SLE mice.

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Fas gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus

Bohat,

Liang,

Chen

et al. 2024

Clinical Immunology

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Genetic polymorphisms of IL-27 and risk of systemic lupus erythematosus disease in the Egyptian population

Cited by 7 publications

References 27 publications

Immunogenetic Relationship of HLA-G 14 bp Insertion/Deletion Polymorphism and Toll-Like Receptor 9 with Systemic Lupus Erythematosus in Egyptian Patients: A Case-Control Study

Immunogenetic Relationship of HLA-G 14 bp Insertion/Deletion Polymorphism and Toll-Like Receptor 9 with Systemic Lupus Erythematosus in Egyptian Patients: A Case-Control Study

Effects of Astragalus membranaceus on systemic lupus erythematosus in a mouse model of pregnancy

Fas gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus

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