Genetic polymorphisms of microsomal epoxide hydroxylase and glutathione S-transferases M1, T1 and P1, interactions with smoking, and risk for esophageal (Barrett) adenocarcinoma

Casson, Alan G.; Zheng, Zuoyu; Porter, Geoffrey A.; Guernsey, Duane L.

doi:10.1016/j.cdp.2006.09.005

Cited by 52 publications

(63 citation statements)

References 35 publications

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“…Our search strategy and inclusion criteria (the publication selection process is shown in Figure 1), 8 studies were identified with full-text articles that remained with association between EPHX 1 (Tyr113His and His139Arg) polymorphisms and EC (Zhang et al, 2003;Wang et al, 2003;Casson et al, 2003Casson et al, , 2006Lin et al, 2006;Jain et al, 2008;Ihsan et al, 2010;Dura et al, 2012). Among the included articles, 7 articles provided separate data for the EPHX1 Tyr113His and EPHX1 His139Arg polymorphisms Casson et al, 2003Casson et al, , 2006Lin et al, 2006;Jain et al, 2008;Ihsan et al, 2010;Dura et al, 2012), which were treated as 2 separate studies.…”

Section: Characteristics Of Relevant Studiesmentioning

confidence: 99%

“…Next, the active intermediates are subjected to detoxification by Phase II enzymes. Microsomal epoxide hydrolase (EPHX1) is the phase-II xenobiotic biotransformation enzyme that plays a dual effect in the detoxification and activation of procarcinogens (Casson et al, 2006). The Tyr113His (exon 3) and His139Arg (exon 4) EPHX1 variants have been identified in the protein sequences.…”

Section: Introductionmentioning

confidence: 99%

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EPHX1 Tyr113His and His139Arg polymorphisms in esophageal cancer risk: a meta-analysis

Tan

Wang

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Microsomal epoxide hydrolase 1 (EPHX1) is an important biological phase II metabolic enzyme that is extensively involved in the metabolism of diverse environmental carcinogens such as polycyclic aromatic hydrocarbons and heterocyclic amines. Many articles have reported the association between EPHX1 (Tyr113His and His139Arg) polymorphisms and esophageal cancer risk, but the results are controversial. This study aimed to identify the association between EPHX1 (Tyr113His and His139Arg) polymorphisms and esophageal cancer risk by meta-analysis. The odds ratio (OR) with 95% confidence interval (95%CI) was used to evaluate the strength of the associations. Heterogeneity was estimated by the chi-square-based Q-statistic test and the P value. Meanwhile, the random-effect or fixed-effect model was used according to the between-study heterogeneity. Begg's funnel plot and the Egger test were performed to assess the publication bias of articles. Finally, 8 case-control studies involving 1158 cases and 1868 controls for the Tyr113His polymorphism and 7 case-control studies involving 901 cases and 1615 controls for the His139Arg polymorphism were included in this meta-analysis. Meta-analysis showed that the Tyr113His polymorphism was a stronger power trend towards risk for esophageal cancer using a recessive model (CC versus CT+TT, OR = 1.204, 95%CI = 1.001-1.450, P = 0.049). However, no significant associated risk was found between the His139Arg polymorphism and esophageal cancer. These findings suggest that the Tyr113His polymorphism might be a stronger power trend towards risk for esophageal cancer. However, no evidence was found for the association between the EPHX1 His139Arg polymorphism and esophageal cancer risk.

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Section: Characteristics Of Relevant Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

EPHX1 Tyr113His and His139Arg polymorphisms in esophageal cancer risk: a meta-analysis

Tan

Wang

et al. 2014

Genet. Mol. Res.

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“…Further application of our inclusion/exclusion criteria left 9 articles (Zhang et al, 2003;Casson et al, 2003Casson et al, , 2006Lin et al, 2006;Wang et al, 2003Wang et al, , 2006Jain et al, 2008;Ihsan et al, 2010;Dura et al, 2012), including 8 studies for the Tyr113His polymorphism with 1158 EC cases and 1868 controls Zhang et al, 2003;Casson et al, 2003Casson et al, , 2006Lin et al, 2006;Jain et al, 2008;Ihsan et al, 2010;Dura et al, 2012), and 7 studies for His139Arg with 901 EC and 1615 controls Casson et al, 2003Casson et al, , 2006Lin et al, 2006;Jain et al, 2008;Ihsan et al, 2010;Dura et al, 2012). The detailed selection process and the baseline characteristics of the qualified studies are presented in Figure 1 and Table 1, respectively.…”

Section: Description Of Available Studiesmentioning

confidence: 99%

“…Considering the fact that ethnicity differences may bias the overall estimates, we therefore conducted separate analyses based on ethnicity, where we classified 8 study populations into Chinese Zhang et al, 2003;Lin et al, 2006), Caucasians (Casson et al, 2003(Casson et al, , 2006Dura et al, 2012), and Indians (Jain et al, 2008;Ihsan et al, 2010). As shown in Table 2, albeit nonsignificant, comparison of 113Tyr versus 113His generated a weakly protective tendency for EC in Chinese (OR = 0.87; 95%CI = 0.59-1.29; P = 0.495), Caucasians (OR = 0.86; 95%CI = 0.57-1.30; P = 0.477), and Indians (OR = 0.83; 95%CI = 0.57-1.22; P = 0.352), Similar tendencies were noted for other genetic models except for Caucasians in the recessive model (OR = 1.01; 95%CI = 0.52-1.98; P = 0.976) ( Table 2).…”

Section: Tyr113his Polymorphism and Ecmentioning

confidence: 99%

“…Variations in enzyme activity of EPHX1 as a result of such polymorphisms may lead to interindividual variations in susceptibility to chemical carcinogen-induced cancers, including EC. Although some studies have attempted to link EPHX1 gene Tyr113His and His139Arg polymorphisms to EC, the resulting data are not often reproducible (Zhang et al, 2003;Casson et al, 2003Casson et al, , 2006Lin et al, 2006;Wang et al, , 2006Jain et al, 2008;Ihsan et al, 2010;Dura et al, 2012). As a caveat, failure of replication may result from the genetic heterogeneity between different races or ethnicities, as well as individual studies with relatively low statistical power.…”

Section: Introductionmentioning

confidence: 99%

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Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk

Hu¹,

Wang²,

Li³

2013

Genet. Mol. Res.

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ABSTRACT. Epoxide hydrolases metabolize exogenous chemicals, including carcinogens such as polycyclic aromatic hydrocarbons. The relationship between microsomal epoxide hydrolase 1 (EPHX1) polymorphisms and esophageal cancer risk has been investigated in various ethnic populations, but the results have been contradictory. We investigated the association of EPHX1 Tyr113His and His139Arg polymorphisms with esophageal cancer via a comprehensive metaanalysis. Publications before August 20, 2012 were included. Eight studies concerning Tyr113His polymorphism associated with 1158 esophageal cancer cases and 1868 controls were identified; 7 studies concerning association of His139Arg with 901 esophageal cancer cases and 1615 controls were also included. A random-effect model was applied, irrespective of between-study heterogeneity. Data and study quality were assessed in duplicate. No significant association was found in either the allele or genotype models for Tyr113His or His139Arg EPHX1 polymorphisms and esophageal cancer risk polymorphism with risk for esophageal cancer. Lack of association was also identified in stratified analyses by ethnicity. No publication bias was observed. We conclude that current evidence does not demonstrate association of EPHX1 Tyr113His or His139Arg polymorphisms with risk for development of esophageal cancer.

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Esophageal adenocarcinoma: risk factors

Naveed

Dunbar²

2015

Esophageal Cancer and Barrett's Esophagus

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Genetic polymorphisms of microsomal epoxide hydroxylase and glutathione S-transferases M1, T1 and P1, interactions with smoking, and risk for esophageal (Barrett) adenocarcinoma

Cited by 52 publications

References 35 publications

EPHX1 Tyr113His and His139Arg polymorphisms in esophageal cancer risk: a meta-analysis

EPHX1 Tyr113His and His139Arg polymorphisms in esophageal cancer risk: a meta-analysis

Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk

Esophageal adenocarcinoma: risk factors

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