Genetic polymorphisms of paraoxonase 1 and susceptibility to atherogenesis

Grubisa, Ivana; Otašević, Petar; Dimković, Nada; Nedeljković, Ivana; Toljic, Bosko; Vucinic, Nada

doi:10.2298/sarh1310629g

Cited by 12 publications

(4 citation statements)

References 20 publications

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“…Neither the PON1 nor the 9p21.3 locus haplotype improved the estimation of independent risk. These findings are in agreement with the results of Grubisa et al (2013).…”

Section: Discussionsupporting

confidence: 94%

Genetic variants of PON1, GSTM1, GSTT1, and locus 9p21.3, and the risk for premature coronary artery disease in Yucatan, Mexico

García-González

Pérez-Mendoza

Solís-Cárdenas

et al. 2021

American J Hum Biol

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Objective: Genetic variants of PON1, rs70587, rs662, rs854560, GSTM1, and GSTT1 and two single nucleotide polymorphisms (SNP) at 9p21.3 locus, rs1333049, and rs2383207; were evaluated in association with the risk for premature coronary artery disease (CAD) in a population of Yucatan, Mexico.These genes are involved in the inactivation of pro-oxidants and proinflammatory mediators, lipid and xenobiotic metabolism, detoxification of reactive oxygen species, and regulation of cellular proliferation playing key roles in the pathogenesis of atherosclerosis.Methods: We conducted a matched case-control study with 98 CAD cases and 101 healthy controls. Genotyping of PON1 and 9p21.2 SNP was performed by real time-PCR and for GSTM1 and GSTT1 with multiplex-PCR. Odds ratios (OR) were calculated to estimate association and generalized multifactor dimensionality reduction (GMDR) algorithm to identify gene-gene and geneenvironment interactions. Results:The distribution of all allele/genotype frequencies in controls was within Hardy-Weinberg expectations (p > .05) except for GSTM1. The allele/ genotype frequencies of the GSTT1 null were significantly higher in CAD cases than in controls, suggesting association with higher risk for developing CAD.

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“…Neither the PON1 nor the 9p21.3 locus haplotype improved the estimation of independent risk. These findings are in agreement with the results of Grubisa et al (2013).…”

Section: Discussionsupporting

confidence: 94%

Genetic variants of PON1, GSTM1, GSTT1, and locus 9p21.3, and the risk for premature coronary artery disease in Yucatan, Mexico

García-González

Pérez-Mendoza

Solís-Cárdenas

et al. 2021

American J Hum Biol

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show abstract

“…The genotype frequency observed in this study is in agreement with that of other studies. 28 , 29 , 30 For instance, the CHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas) cohort, carried out with children of the same age group, recorded a frequency similar to that found in this study. 28 , 30 …”

Section: Discussionsupporting

confidence: 80%

Influence of nutritional factors and the PON1 C(-107)T polymorphism on paraoxonase-1 activity in childhood

Sigales

Uliano

Muniz

et al. 2020

Jornal de Pediatria

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“…Logistic regression analysis showed that alleles or genotypes were not risk factors for atherosclerosis. 18 In a Chinese study, the PON1 Q192R polymorphism has been found to have a major effect on the risk of CAD development, and logistic regression analysis has indicated that the 192R allele is associated with a higher risk of CAD than other alleles. Significantly lower serum PON1 activity and concentration have also been observed in patients with CAD than controls.…”

Section: Discussionmentioning

confidence: 99%

Paraoxonase gene polymorphisms: Understanding the biochemical and genetic basis of coronary artery disease

Nasreen¹,

Gayathri

2023

Journal of Taibah University Medical Sciences

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Genetic polymorphisms of paraoxonase 1 and susceptibility to atherogenesis

Abstract: These polymorphisms cannot be considered risk factors of atherosclerosis in Serbian population. A larger study is required in order to establish possible contribution of pon1 variants to atherosclerosis-related cardiovascular diseases.

Cited by 12 publications

References 20 publications

Genetic variants of PON1, GSTM1, GSTT1, and locus 9p21.3, and the risk for premature coronary artery disease in Yucatan, Mexico

Genetic variants of PON1, GSTM1, GSTT1, and locus 9p21.3, and the risk for premature coronary artery disease in Yucatan, Mexico

Influence of nutritional factors and the PON1 C(-107)T polymorphism on paraoxonase-1 activity in childhood

Paraoxonase gene polymorphisms: Understanding the biochemical and genetic basis of coronary artery disease

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