2014
DOI: 10.1089/gtmb.2014.0077
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Genetic Polymorphisms of Platelet Receptors in Patients with Acute Myocardial Infarction and Resistance to Antiplatelet Therapy

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Cited by 28 publications
(20 citation statements)
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“…Most studies focused on rs2046934 (T744C) or rs6809699 (G52T) representing dbSNP rs10935838, rs2046934, rs5853517 and rs6809699, and rs6785930 (C34T). Some found that it can modulate platelet response to clopidogrel or affect patients' outcomes (Fontana et al, 2003;Zee et al, 2008;Staritz et al, 2009;Shalia et al, 2013;Zoheir et al, 2013;Li et al, 2016), but most results were negative (Angiolillo et al, 2005;Smith et al, 2006;Cuisset et al, 2007;Lev et al, 2007;Bierend et al, 2008;Bonello et al, 2010;Jang et al, 2012;Namazi et al, 2012;Kar et al, 2013;Kim et al, 2013;Jana et al, 2014). Our results show that the P2RY12 allele rs2046934 (T744C) was not significantly associated with HTPR neither in the total study population nor in nonsmokers.…”
Section: Discussioncontrasting
confidence: 51%
See 1 more Smart Citation
“…Most studies focused on rs2046934 (T744C) or rs6809699 (G52T) representing dbSNP rs10935838, rs2046934, rs5853517 and rs6809699, and rs6785930 (C34T). Some found that it can modulate platelet response to clopidogrel or affect patients' outcomes (Fontana et al, 2003;Zee et al, 2008;Staritz et al, 2009;Shalia et al, 2013;Zoheir et al, 2013;Li et al, 2016), but most results were negative (Angiolillo et al, 2005;Smith et al, 2006;Cuisset et al, 2007;Lev et al, 2007;Bierend et al, 2008;Bonello et al, 2010;Jang et al, 2012;Namazi et al, 2012;Kar et al, 2013;Kim et al, 2013;Jana et al, 2014). Our results show that the P2RY12 allele rs2046934 (T744C) was not significantly associated with HTPR neither in the total study population nor in nonsmokers.…”
Section: Discussioncontrasting
confidence: 51%
“…As well as CYP2C19, other genetic factors may contribute to the inter-individual variability of clopidogrel, among which P2RY12, which encodes the P2Y12 receptor on platelets, is of importance. Previous studies have implied that P2RY12 single nucleotide polymorphism (SNP) might play a role on the large variability in clopidogrel response, but the results were inconsistent and controversial (Angiolillo et al, 2007;Zee et al, 2008;Jana et al, 2014;Oestreich et al, 2014;Li et al, 2016;Zhang et al, 2016). Most of those studies focused on single haplotype-tagging SNPs (ht-SNPs), such as rs2046934 (i-T744C) or rs6785930, or two common haplotypes H 1 and H 2 (constituted by single nucleotide polymorphism database (dbSNP) rs10935838, rs2046934, rs5853517, and rs6809699), especially the previous studies in the Chinese population (Chen et al, 2014;Zhang et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…We investigated the 13254 locus for the GPVI gene and its polymorphism T>C. The replacement of nucleotide bases in that area causes proline to serine substitution at position 219; therefore the binding function of GPVI may be affected. There are a few trials studying the 13254T/C polymorphism in relation to higher risk of ischaemic events, with inconsistent results [ 25 27 ]. We did not find any differences in C allele frequency between the bleeding and non-bleeding group (OR = 0.82, 95% CI: 0.40–1.64, p = 0.551).…”
Section: Discussionmentioning
confidence: 99%
“…Aspirin may effectively inhibit the activities of platelet COX1, but aspirin dose less than 100 mg/day is an independent predictor of aspirin resistance . Polymorphism of COX1 (‐842A > G) is significantly correlated with aspirin resistance . In addition, platelet glycoprotein IIIa (GPIIIa) gene polymorphism (‐33L > P) or GPIIIa overexpression is linked to aspirin resistance .…”
Section: Aspirin Resistancementioning
confidence: 99%