Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients

Rossi, L; Leveri, Michela; Gritti, Chiara; Silvestri, Annalisa De; Zavaglia, Claudio; Sonzogni, Laura; Silvestri, Laura; Civardi, Emilio; Mondelli, Mario U.; Silini, Enrico Maria

doi:10.1016/s0168-8278(03)00355-6

Cited by 25 publications

(21 citation statements)

References 32 publications

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“…For instance, no association of the two CYP1A1 polymorphisms, MspI and Ile462Val, was observed with the hepatocellular carcinoma risk in either chronic hepatitis B carriers or hepatitis C virus -infected patients (29,30). It was also reported that the CYP17 MspAI and COMT Val158Met are not associated with the risk for hepatitis C virus -related hepatocellular carcinoma (31). The conflicting results could be attributable to the differences in demography, ethnicity, lifestyles, type of viral infections, and clinical settings.…”

Section: Discussionmentioning

confidence: 99%

Lack of Association between the Functional Polymorphisms in the Estrogen-Metabolizing Genes and Risk for Hepatocellular Carcinoma

Yuan¹,

Zhou²,

Zhai³

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Estrogens have been proposed to act as tumor promoters and induce hepatocarcinogenesis. Recently, we observed a significant association between the risk for hepatocellular carcinoma and the polymorphisms of the estrogen receptor (ESR) A (ESR1) gene, supporting the hypothesis of involvement for the estrogen-ESR axis in the estrogeninduced hepatocarcinogenesis. In this study, based on another hypothesis in which estrogen metabolites can directly cause DNA damage and affect tumor initiation, we examined whether the polymorphisms of the estrogen-metabolizing enzymes (EME), which are involved in biogenesis (CYP17, CYP19), bioavailability (CYP1A1, CYP1B1), and degradation (catechol-O-methyltransferase) of the estrogens, have any bearing on the risk for hepatocellular carcinoma. Seven functional polymorphisms in five EMEs (CYP17 MspAI site, CYP19 Trp39Arg, Ile462Val and MspI site in CYP1A1, CYP1B1 Val432Leu, and Ala72Ser and Val158Met in catechol-O-methyltransferase) were genotyped in 434 patients with hepatocellular carcinoma and 480 controls by PCR-RFLP analysis. The associations between the polymorphisms and hepatocellular carcinoma risk were evaluated while controlling for confounding factors. No significant association with the risk for hepatocellular carcinoma was observed with the seven polymorphisms in hepatitis B virus carriers and non-hepatitis B virus carriers after correction for multiple comparisons. After stratification by common confounding factors of hepatocellular carcinoma, the EME polymorphism remained no significant association with the hepatocellular carcinoma risk. Furthermore, no signs of gene-gene interactions were observed for each combination of the seven polymorphisms. Our findings suggest that the polymorphisms of EMEs may not contribute significantly to the risk for hepatocellular carcinoma. (Cancer Epidemiol Biomarkers Prev 2008;17(12):3621 -7)

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Section: Discussionmentioning

confidence: 99%

Lack of Association between the Functional Polymorphisms in the Estrogen-Metabolizing Genes and Risk for Hepatocellular Carcinoma

Yuan¹,

Zhou²,

Zhai³

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…For decades of years, there were a lot of studies explored the relationship of polymorphisms of candidate gene and HCC (Yuan et al 2007;Tanabe et al 2008;Akkiz et al 2009;Imaizumi et al 2009;Ognjanovic et al 2009). Because liver is the largest metabolic organ in human body, the candidate SNPs studied mainly related to the genes encoding carcinogen-metabolising enzymes, such as cytochrome P450 superfamily (CYPs) (Rossi et al 2003;Silvestri et al 2003;Yuan et al 2008), UDP-glucuronosyltransferases (UGTs) (Vogel et al 2001;Wang et al 2004), and hemochromatosis (HFE) (Shi et al 2005;Ropero et al 2007;Ezzikouri et al 2008a, b). The other involved genes included inflammatory related genes, such as interleukin (ILs) (Wang et al 2004;Migita et al 2007), tumor necrosis factor-alpha (TNFa) (Oh et al;Akkiz et al 2009), and oncogenes, such as MDM2 (mouse double minute 2) Dharel et al 2006;Yoon et al 2008;Ezzikouri et al 2009;Leu et al 2009), and so on.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review

Jin

Xiong

Jing

et al. 2011

J Cancer Res Clin Oncol

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“…In particular, it was pointed out that a group led by Professor HE Fuchu from Chinese Military Medical Institute recently researched the close relationship [37] between the polymorphisms of estrogen receptors and the susceptibility of liver cancer using the strategies of case-control study exams. Cytochrome P450 isoenzyme isomerase CYP1A2 related to AFB1 metabolism, and the polymorphism of CYP17 correlated with steroid hormone metabolism are also associated with liver cancer risk [38,39] .…”

Section: Susceptibility Gene Of Liver Cancermentioning

confidence: 99%

Recent progress in 8igenomic research of liver cancer

Han

2009

SCI CHINA SER C

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Along the course of occurrence and development of liver cancer, the corresponding somatic cells accumulate some important genetic variations. These variations may be divided into two categories. For the genetic changes closely related to etiology of liver cancer, the well-known cases include insertion and integration of the hepatitis B virus (HBV) DNA after infection, and mutations at site 249 of the tumor suppressor gene p53 induced by exposure to aflatoxin B1. The secondary genetic changes include amplification and deletion of certain chromosome regions, mutations in p53 at the sites other than 249, as well as the mutational activation of the Wnt/beta-catenin signal pathway. The tumor cells with these genetic variations may gradually become the dominant clones under evolutionary selection. Besides, identification of genetic susceptible against risk of liver malignancy is also an important aspect of research in this field.

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Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients

Cited by 25 publications

References 32 publications

Lack of Association between the Functional Polymorphisms in the Estrogen-Metabolizing Genes and Risk for Hepatocellular Carcinoma

Lack of Association between the Functional Polymorphisms in the Estrogen-Metabolizing Genes and Risk for Hepatocellular Carcinoma

Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review

Recent progress in 8igenomic research of liver cancer

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