Genetic Polymorphisms of the CYP19A1 Gene and Breast Cancer Survival

Abstract

The CYP19A1 protein (aromatase) plays a critical role in estrogen biosynthesis and thus may be related to the progression of breast cancer. We examined the association between CYP19A1 genetic polymorphisms and breast cancer survival in a cohort of 1,136 patients who were recruited as part of a population-based case-control study in Shanghai, China from 1996 to 1998 and who has donated a DNA sample to the study. Patients were followed for cancer recurrence and mortality through July 2005. Nineteen haplotype tagging single-nucleotide polymorphisms (SNP) in the CYP19A1 gene were evaluated. For each of the five SNPs located in haplotype block 2, patients homozygous for the minor alleles had a reduced 5-year disease-free survival rate compared with those carrying the major allele. The age-adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) were

The CYP19 TTTA Repeat Polymorphism Is Related to the Prognosis of Premenopausal Stage I–II and Operable Stage III Breast Cancers

“…Our results are consistent with those reported in a recent study conducted in a Chinese population in Shanghai, in which CYP19 polymorphism was associated with survival in premenopausal breast cancer patients [31]. In that study, a haplotype approach based on 19 tagging SNPs was used to evaluate the contribution of CYP19 and showed that each of [31]. These associations were only observed in premenopausal women.…”

“…Studies of menopausal symptoms and breast cancer survival after tamoxifen treatment have provided support for the benefit of a greater change in hormonal levels on survival, because those with a worse survival experience a lower incidence of hot flushes [29,30]. Our results are consistent with those reported in a recent study conducted in a Chinese population in Shanghai, in which CYP19 polymorphism was associated with survival in premenopausal breast cancer patients [31]. In that study, a haplotype approach based on 19 tagging SNPs was used to evaluate the contribution of CYP19 and showed that each of [31].…”

Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer

“…5 As a result, genetic variation in genes involved in hormone metabolism and signaling have been studied as possible indicators of breast cancer survival. [6][7][8][9][10] These studies have been limited by their small size and limited follow-up, yet have yielded some nominally significant findings. In particular, the Met158Val polymorphism (rs4680) in COMT and several SNPs in CYP19A1 were found to be associated with breast cancer survival in a large Chinese population-based case-control study.…”

“…In particular, the Met158Val polymorphism (rs4680) in COMT and several SNPs in CYP19A1 were found to be associated with breast cancer survival in a large Chinese population-based case-control study. 7,8 Additionally, in a population-based case-control study in Seoul, Korea SNP IVS4-1653 (rs3775775) in SULT1E1 was significantly associated with increased recurrence of breast cancer. 6 In this study, we have focused on 6 genes involved in steroid hormone metabolism and signaling: COMT, CYP19A1, ESR1, PGR, SULT1E1, STS.…”

Rs1008805 polymorphism of CYP19A1 gene is associated with the efficacy of hormone therapy in stage I‑II and operable stage III breast cancer

“…The rs1008805 polymorphism (A/G) is located in block 3. The frequency of the minor allele (G) is approximately 29.5% in Chinese females (22). A study conducted in Chinese population demonstrated that single nucleotide polymorphisms (SNPs) in block 1 and 2 of CYP19A1 gene were associated with the plasma levels of estrogen in postmenopausal females (23).…”