Genetic polymorphisms of the matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases-1 (TIMP-1) modulate the development of ankylosing spondylitis

Wei, James Cheng‐Chung; Lee, Hong-Shen; Chen, Wei-Chiao; Shiu, Li-Jie; Yang, Shun-Fa; Wong, Ruey-Hong

doi:10.1136/ard.2008.099481

Cited by 16 publications

(13 citation statements)

References 41 publications

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“…However, the reports about the association of RUNX3 with AS in Han Chinese population have not been found yet. Besides, based on the specific genetic loci studies, many genes such as Fc receptor-like molecule 4 (FCRL4) [45] and Fc gamma receptor IIB (FCGR2B) [46] in Han ethnic Chinese population and matrix metallopeptidase 3 (MMP-3) [47], TIMP metallopeptidase inhibitor 1 (TIMP-1) [47], and ORAI calcium release-activated calcium modulator 1 (ORAI1) [48] in Taiwanese Chinese population were reported to be associated with AS development. …”

Section: Other Non-mhc Regionsmentioning

confidence: 99%

Immunogenetic Study in Chinese Population with Ankylosing Spondylitis: Are There Specific Genes Recently Disclosed?

Zhai

et al. 2013

Clinical and Developmental Immunology

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Purpose. Ankylosing spondylitis (AS) is a systemic, autoimmune disease resulting in the destruction of the affected joints. Over the past 5 years, several new genes or genetic regions associated with AS have been identified in the Chinese population. This paper aims to discuss the major findings and related potential mechanisms of these studies in our population. Recent Findings. In recent years, due to the rapid advances in computational genetics and technology, there has been an increasing list of well-validated genes or genetic regions associated with AS susceptibility. So far, several genes or genetic regions have now been reported in the Han ethnic Chinese population, containing the major histocompatibility complex (MHC), ERAP1, IL-23R, 12q12, 2p15, 5q14.3, and so on. Different hypotheses for disease mechanisms have been investigated on the basis of the functional studies of these genes or genetic regions. Summary. This paper tries to summarize the association of several candidate genes with risk for AS in the Han ethnic Chinese population and aims to identify the novel inflammatory pathways and provide potential strategies for better therapies.

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Section: Other Non-mhc Regionsmentioning

confidence: 99%

Immunogenetic Study in Chinese Population with Ankylosing Spondylitis: Are There Specific Genes Recently Disclosed?

Zhai

et al. 2013

Clinical and Developmental Immunology

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“…Genetic factors affect not only AS development but also contribute to the severity of the disease 22,23 . Using a case-control study, we investigated the relationship of the IL-12B and IL-23R genotypes with the development and clinical characteristics of AS in Taiwanese patients.…”

mentioning

confidence: 99%

Association of IL-12B Genetic Polymorphism with the Susceptibility and Disease Severity of Ankylosing Spondylitis

Wong¹,

Wei²,

Huang³

et al. 2011

J Rheumatol

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“…Moreover, if the censoring time is essentially independent of the event times of interest, the proposed model is comprehensive and can account for this situation as a special case with˛D 0. Let ƒ 10 .t /; ƒ 20 .t / and ƒ c0 .t / denote the integrated hazard functions of 10 .t /; 20 .t / and c0 .t /, respectively. Define Q C D minfC; g, with being an administrative censoring due to the end of the study, or Q C D minfC; ; C g when there is a further censoring time C independent of .T 1 ; T 2 ; C /.…”

Section: Model and Assumptionsmentioning

confidence: 99%

“…Liu and Huang [18] had discussed the advantages of the techniques and advocated their use in various frailty models. Because Gaussian quadrature techniques cannot be applied when 10 .t /; 20 .t / and c0 .t / are not specified, to adopt these techniques for our study, we approximate the unknown baseline hazard functions, 10 .t /; 20 .t / and c0 .t /, with piecewise constant functions [18,19]. Moreover, the piecewise constant functions provide good approximations to various shapes of unknown functions.…”

Section: Parameter Estimationmentioning

confidence: 99%

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Regression analysis of multivariate current status data with dependent censoring: application to ankylosing spondylitis data

Chen

Wei

Hsu

et al. 2013

Statistics in Medicine

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Multivariate current-status failure time data consist of several possibly related event times of interest, in which the status of each event is determined at a single examination time. If the examination time is intrinsically related to the event times, the examination is referred to as dependent censoring and needs to be taken into account. Such data often occur in clinical studies and animal carcinogenicity experiments. To accommodate for possible dependent censoring, this paper proposes a joint frailty model for event times and dependent censoring time. We develop a likelihood approach using Gaussian quadrature techniques for obtaining maximum likelihood estimates. We conduct extensive simulation studies for investigating finite-sample properties of the proposed method. We illustrate the proposed method with an analysis of patients with ankylosing spondylitis, where the examination time may be dependent on the event times of interest.

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Genetic polymorphisms of the matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases-1 (TIMP-1) modulate the development of ankylosing spondylitis

Abstract: The findings highlight the importance of the MMP-3 and TIMP-1 genes as crucial elements in AS development.

Cited by 16 publications

References 41 publications

Immunogenetic Study in Chinese Population with Ankylosing Spondylitis: Are There Specific Genes Recently Disclosed?

Immunogenetic Study in Chinese Population with Ankylosing Spondylitis: Are There Specific Genes Recently Disclosed?

Association of IL-12B Genetic Polymorphism with the Susceptibility and Disease Severity of Ankylosing Spondylitis

Regression analysis of multivariate current status data with dependent censoring: application to ankylosing spondylitis data

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