Genetic polymorphisms of TP53 and FAS promoter modulate the progression of coronary artery disease after coronary artery bypass grafting: a gender-specific view

Beiras-Fernandez, A.; Angele, Martin K.; Koutang, C.; Reichart, Bruno; Eifert, Sandra

doi:10.1007/s00011-010-0282-5

Cited by 12 publications

(5 citation statements)

References 23 publications

(30 reference statements)

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“…We found in our study that the TP53 level was up regulated in ACAT, suggesting that the TP53 gene contributes to the progression of ATH development. These findings further support the idea of Beiras-Fernandez et al (2011), who suggested that polymorphisms in the TP53 gene increased the risk of CAD progression. A previous study also suggested that cellular death by apoptosis occurs within atherosclerotic lesions (Lesauskaite et al, 2003).…”

Section: Discussionsupporting

confidence: 88%

Preliminary assessment of differential expression of candidate genes associated with atherosclerosis

et al. 2013

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Identifying susceptible genes associated with the pathogenesis of atherosclerosis (ATH) may contribute toward better management of this condition. This preliminary study was aimed at assessing the expression levels of 11 candidate genes, namely tumor protein (TP53), transforming growth factor, beta receptor II (TGFBR2), cysthathionenine-beta-synthase (CBS), insulin receptor substrate 1 (IRS1), lipoprotein lipase (LPL), methylenetetrahydrofolate reductase (MTHFR), thrombomodulin (THBD), lecithin-cholesterol acyltransferase (LCAT), matrix metallopeptidase 9 (MMP9), low density lipoprotein receptor (LDLR), and arachidonate 5-lipoxygenase-activating protein (ALOX5AP) genes associated with ATH. Twelve human coronary artery tissues (HCATs) were obtained from deceased subjects who underwent post-mortem procedures. Six atherosclerotic coronary artery tissue (ACAT) samples representing the cases and non-atherosclerotic coronary artery tissue (NCAT) samples as controls were gathered based on predetermined inclusion and exclusion criteria. Gene expression levels were assessed using the GenomeLab Genetic Analysis System (GeXP). The results showed that LDLR, TP53, and MMP9 expression levels were significantly increased in ACAT compared to NCAT samples (p < 0.05). Thus, LDLR, TP53, and MMP9 genes may play important roles in the development of ATH in a Malaysian study population.

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Section: Discussionsupporting

confidence: 88%

Preliminary assessment of differential expression of candidate genes associated with atherosclerosis

et al. 2013

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“…it has been already demonstrated that the R variant of p53 is associated with higher risk of recurrence of coronary atherosclerotic disease (5). oxidative stress has long been known to be a part of the pathogenetic mechanism in diabetes type 2 and one of the major factors in development of complications (3,40).…”

Section: Possible Aspects Of Application Of the Mini-panelmentioning

confidence: 99%

Children of the Sun, Children of the Moon—A Mini-Panel for Assessment of Inter-Individual Variation Between the Capacity of Healthy Individuals to Repair Everyday Genotoxic Insults

Chicheva¹,

Chelenkova²,

Petkova³

et al. 2012

Biotechnology & Biotechnological Equipment

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“…The growth of VSMCs was caused by the loss of TP53 activity, while the increase of TP53 level can lead to apoptosis of VSMCs. Plaque VSMCs are more susceptible to apoptosis mediated by TP53 than normal VSMCs [38]. The research hypothesized that the serum concentrations of EGF and other cytokines/growth factors may play a signi cant role in the pathogenesis of CHD, which the nal conclusion was as follow: the concentration of EGF in serum of patients with CHD was higher than that in normal people [39].…”

Section: Discussionmentioning

confidence: 99%

A Multi-Scale Bioinformatics Study on Novel Mechanism of Xintong Granule for Treating Coronary Heart Disease by Network Pharmacology and Molecular Docking Verification

Huang¹,

Guo²,

Fu³

et al. 2020

Preprint

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Background: Xintong Granule (XTG) is a Chinese patent medicine composed of 13 Chinese herbs, which is widely used in the treatment of coronary heart disease (CHD). However, there are few studies on it, and its potential pharmacological mechanism needs to be further elucidated.Methods: In this study, network pharmacology was employed to construct the drug-compounds-targets-pathways molecular regulatory network of the treatment of CHD to explore the effective compounds of XTG and its underlying pharmacological mechanism. First, we established the related ingredients and potential targets of these ingredients databases by Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) and A Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine (BATMAN-TCM). Next, the CHD targets were obtained in DigSee, OMIM, DisGeNET, TTD, GeneCards and GenCLiP3 database. Then, protein-protein interaction (PPI) analysis, GO and KEGG pathway enrichment analysis were carried out and the core targets were filtered by topology. Moreover, molecular docking was performed to assess the binding potential of hub targets and key compounds.Results: The result reflected that 178 components of XTG and 669 putative therapeutic targets were screened out. After a systematic and comprehensive analysis, we identified 9 hub targets (TNF, MAPK1, STAT3, IL6, AKT1, INS, EGFR, EGF, TP53) primarily participated in the comprehensive therapeutic effect related to blood circulation, vascular regulation, cell membrane region, compound binding, receptor activity, signal transduction, AGE-RAGE signaling pathway in diabetic complications, JAK-STAT signaling pathway, PI3K-AKT signaling pathway and MAPK signaling pathway.Conclusion: The results of this study tentatively clarified the potential targets and signaling pathways of XTG against CHD, which may benefit to the development of clinical experimental research and application.

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Genetic polymorphisms of TP53 and FAS promoter modulate the progression of coronary artery disease after coronary artery bypass grafting: a gender-specific view

Abstract: Patients presenting with polymorphisms of FAS LG, FAS promoter and TP53 have an increased risk of CAD progression, as they have a higher rate of re-interventions.

Cited by 12 publications

References 23 publications

Preliminary assessment of differential expression of candidate genes associated with atherosclerosis

Preliminary assessment of differential expression of candidate genes associated with atherosclerosis

Children of the Sun, Children of the Moon—A Mini-Panel for Assessment of Inter-Individual Variation Between the Capacity of Healthy Individuals to Repair Everyday Genotoxic Insults

A Multi-Scale Bioinformatics Study on Novel Mechanism of Xintong Granule for Treating Coronary Heart Disease by Network Pharmacology and Molecular Docking Verification

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