Genetic polymorphisms of xeroderma pigmentosum group D gene Asp312Asn and Lys751Gln and susceptibility to prostate cancer: A systematic review and meta-analysis

Ma, Qing-Tong; Qi, Can; Chong, Tie; Guo, Zhanjun

doi:10.1016/j.gene.2013.08.053

Cited by 12 publications

(12 citation statements)

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“…Similar to the previously published studies, we did not find any association between XPD Lys751Gln (rs13181) genotypes and PCa in Chinese populations. For XPC , a meta-analysis for Lys939Gln (rs2228001) [34] of 62 studies including 25708 cases and 30432 controls confirmed an increased cancer risk associated with this polymorphism in the homozygous genetic model for Asian populations, but not for other ethnic groups [35]. Taken together, there are some possible reasons for the inconclusive findings among these meta-analyses.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations

Wang

et al. 2016

Oncotarget

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Genetic variants of nucleotide excision repair (NER) genes have been extensively investigated for their roles in the development of prostate cancer (PCa); however, the published results have been inconsistent. In a hospital-based case-control study of 1,004 PCa cases and 1,055 cancer-free controls, we genotyped eight potentially functional single nucleotide polymorphisms (SNPs) of NER genes (i.e., XPC, rs2228001 T>G and rs1870134 G>C; XPD, rs13181 T>G and rs238406 G>T; XPG, rs1047768 T>C, rs751402 C>T, and rs17655 G>C; and XPF, rs2276464 G>C) and assessed their associations with risk of PCa by using logistic regression analysis. Among these eight SNPs investigated, only XPC rs1870134 CG/CC variant genotypes were associated with a decreased risk of prostate cancer under a dominant genetic model (adjusted odds ratio [OR] = 0.77, 95% confidence interval [CI] = 0.64–1.91, P = 0.003). Phenotype-genotype analysis also suggested that the XPC rs1870134 CG/CC variant genotypes were associated with significantly decreased expression levels of XPC mRNA in a mix population of different ethnicities. These findings suggested that XPC SNPs may contribute to risk of PCa in Eastern Chinese men.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations

Wang

et al. 2016

Oncotarget

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“…In contrast, Yan et al [ 21 ], Hu et al [ 11 ], and Zhu et al [ 112 ] suggested that the ERCC2 Asp312Asn polymorphism was not associated with breast cancer, head and neck cancer, and skin cancer, respectively. Moreover, Chen et al [ 113 ], Feng et al [ 12 ], and Ma et al [ 114 ] suggested that the ERCC2 Asp312Asn polymorphism contributed to the risk of non-Hodgkin lymphoma, lung cancer, and prostate cancer, respectively. Because we only included studies published from 2005 to 2016, we drew different conclusions in lung cancer and prostate cancer studies.…”

Section: Discussionmentioning

confidence: 99%

Association between the ERCC2 Asp312Asn polymorphism and risk of cancer

Xiao

Wen

et al. 2017

Oncotarget

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Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries. The relationship between genetic polymorphisms and the risk of cancers has been widely researched. Excision repair cross-complementing group 2 (ERCC2) gene plays important roles in the nucleotide excision repair pathway. There is contrasting evidence on the association between the ERCC2 Asp312Asn polymorphism and the risk of cancer. We conducted a comprehensive meta-analysis in order to assess the correlation between these factors. We searched the PubMed, EMBASE, Science Direct, Web of Science, and CNKI databases for studies published from January 1, 2005 to January 1, 2016. Finally, 86 articles with 38,848 cases and 48,928 controls were included in the analysis. The overall analysis suggested a significant association between the ERCC2 Asp312Asn polymorphism and cancer risk. Furthermore, control source, ethnicity, genotyping method, and cancer type were used for subgroup analysis. The result of a trial sequential analysis indicated that the cumulative evidence is adequate; hence, further trials were unnecessary in the overall analysis for homozygote comparison. In summary, our results suggested that ERCC2 Asp312Asn polymorphism is associated with increased cancer risk. A significantly increased cancer risk was observed in Asian populations, but not in Caucasian populations. Furthermore, the ERCC2 Asp312Asn polymorphism is associated with bladder, esophageal, and gastric cancers, but not with breast, head and neck, lung, prostate, and skin cancers, and non-Hodgkin lymphoma. Further multi-center, well-designed studies are required to validate our results.

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“…However, results remain conflicting rather than conclusive, which impelled researchers to pay attention to these two polymorphisms at a meta-analytical level. On the whole, three newly updated meta-analyses revealed that there were no evidence supporting that XPD Lys751Gln polymorphism contributed to prostate cancer (Ma et al, 2013) , colorectal cancer (Zhang et al, 2011) , or gastric cancer (Yin et al, 2013). On the contrary, other large sample meta-analyses proposed a greater risk in hepatocellular carcinoma (Guo et al, 2012), breast cancer (Yan et al, 2014), lung cancer , glioma (Chen et al, 2012), and acute myeloid leukemia (AML) (Liu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…On the contrary, other large sample meta-analyses proposed a greater risk in hepatocellular carcinoma (Guo et al, 2012), breast cancer (Yan et al, 2014), lung cancer , glioma (Chen et al, 2012), and acute myeloid leukemia (AML) (Liu et al, 2014). For XPD Asp312Asn polymorphism, three meta-analyses proposed a greater risk in prostate cancer (Ma et al, 2013), gastric cancer (Yin et al, 2013), and esophageal cancer (Duan et al, 2012). However, other large sample meta-analyses showed that it did not contribute to breast cancer (Yan et al, 2014), lung cancer , colorectal cancer (Zhang et al, 2011) or head and neck cancer (Hu et al, 2012) risk.…”

Section: Discussionmentioning

confidence: 99%

XPD Lys751Gln and Asp312Asn Polymorphisms and Susceptibility to Skin Cancer: A Meta-Analysis of 17 Case-control Studies

Zhu¹,

Bao²,

Lin³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Numerous studies have explored the influence of XPD Lys751Gln and/or Asp312Asn polymorphisms on skin cancer susceptibility. However, the results remain inconclusive. To derive a more precise estimation, we conducted a comprehensive search to identify all available published studies and performed a meta-analysis. Materials and Methods: Electronic literature searches of the PubMed, CBM and CNKI databases were performed up to March 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to assess the strength of associations. Results: Seventeen case-control studies were included with a total sample size of 6, 113 cases and 11, 074 controls for the XPD Lys751Gln polymorphism, and 10 studies (3, 840cases and 7, 637 controls) for the XPD Asp312Asn polymorphism were pooled for analysis. Overall, no significant associations were found between the XPD Lys751Gln polymorphism and skin cancer risk in any genetic model. On stratified analysis by tumor type, XPD Lys751Gln polymorphism was not associated with increased risk of non-melanoma skin cancer, but was significantly related with increased risk of cutaneous melanoma (Gln/Gln vs Lys/Lys: OR=1.15, 95%CI=1.02-1.29, p=0.023; dominant model: OR=1.09, 95%CI=1.01-1.18, p=0.036). For the XPD Asp312Asn polymorphism, no significant association with skin cancer risk was observed in overall or subgroup analyses. Conclusions: The present meta-analysis suggests that the XPD Lys751Gln polymorphism may contribute to the risk of cutaneous melanoma from currently available evidence. Further investigations are needed to obtain more insight into possible roles of these two polymorphisms in skin carcinogenesis.

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Genetic polymorphisms of xeroderma pigmentosum group D gene Asp312Asn and Lys751Gln and susceptibility to prostate cancer: A systematic review and meta-analysis

Cited by 12 publications

References 35 publications

Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations

Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations

Association between the ERCC2 Asp312Asn polymorphism and risk of cancer

XPD Lys751Gln and Asp312Asn Polymorphisms and Susceptibility to Skin Cancer: A Meta-Analysis of 17 Case-control Studies

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