Genetic polymorphisms ofp53 andGSTP1,but notNAT2,are associated with susceptibility to squamous-cell carcinoma of the esophagus

Lee, Jang-Ming; Lee, Yung-Chie; Yang, Shi-Yi; Shi, Wan-Luen; Lee, Chun-Jean; Luh, Shi‐Ping; Chen, Chien-Jen; Hsieh, Chang‐Yao; Wu, Ming-Tsang

doi:10.1002/1097-0215(20000920)89:5<458::aid-ijc10>3.0.co;2-r

Cited by 98 publications

(71 citation statements)

References 45 publications

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“…20,21 In spite of the above discrepancy, we observed a similar association between P53 Arg72Pro and ESCC risk compared with Hong's and other previous studies (OR B2 for Pro/Pro genotype compared with Arg/Arg genotype, adjusted for age, sex, smoking or drinking status), though sample size, matching mode and study population were quite different from each other. [13][14][15][16] We confirm that P53 Arg72Pro polymorphism is a common susceptibility factor for ESCC in Chinese populations.…”

Section: Discussionsupporting

confidence: 59%

“…11,12 Till now, the P53 Arg72Pro polymorphism has been well studied in ESCC in Chinese populations. [13][14][15][16] But little is known about the association between MDM2 or PTEN polymorphisms and ESCC susceptibility. 16,17 Here we genotyped MDM2 T309G, Del1518 (rs150550023), PTEN rs701848 and rs2735343 and investigated the associations between these polymorphisms and ESCC risk in a case-control study conducted in a high-risk population of China.…”

Section: Introductionmentioning

confidence: 99%

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Association of genetic polymorphisms in MDM2, PTEN and P53 with risk of esophageal squamous cell carcinoma

Zhang

Ning

et al. 2012

J Hum Genet

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Genetic variations in MDM2, PTEN and P53 might be involved in cancer susceptibility. To assess the contribution of polymorphisms in these three genes to the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese population, we genotyped MDM2 T309G, Del1518, PTEN rs701848, rs2735343 and P53 Arg72Pro polymorphisms using PCR-restriction fragment length polymorphism analysis in 226 ESCC cases and 226 cancer-free controls. Here we showed that the risk of ESCC was elevated in subjects with any of the variant genotypes of PTEN rs2735343 and P53 Arg72Pro polymorphisms, but not any genotype of MDM2 or PTEN rs701848. Moreover, multiplicative interactions were observed between PTEN rs2735343 and P53 Arg72Pro or smoking status on risk of ESCC. Our study firstly indicated that PTEN rs2735343 might be a susceptibility factor for ESCC and reaffirmed the role of P53 Arg72Pro in ESCC in this Chinese population, but did not replicate the positive association between MDM2 T309G and ESCC found previously.

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Section: Discussionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Association of genetic polymorphisms in MDM2, PTEN and P53 with risk of esophageal squamous cell carcinoma

Zhang

Ning

et al. 2012

J Hum Genet

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“…Genomic DNA was extracted from peripheral leukocytes with serial processing with RNase and proteinase K followed by ethanol precipitation. For GSTP1 genotyping, PCR-RFLP was used (21). The primers were 5V -ACCCCAGGGCTCTATGGGAA and 5V -TGAGGGCACAAGAAGCCCCT.…”

Section: Methodsmentioning

confidence: 99%

Association of GSTP1 Polymorphism and Survival for Esophageal Cancer

Lee¹,

Lee³

et al. 2005

Clinical Cancer Research

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Purpose: Activity of glutathione S-transferase (GST) is associated with detoxification of xenobiotics and the maintenance of cell viability. Genetically variant GSTs produce different enzymatic activities.The clinical significance of this variation is still puzzling.We investigated whether genetic polymorphisms of GST including GSTP1, GSTM1, and GSTT1 affect survival among esophageal cancer patients. Experimental Design: From1996 to 2002, 233 patients with pathologically proven esophageal cancer were recruited from the Department of Surgery, National Taiwan University Hospital. GST genotypes, including GSTT1, GSTM1, and GSTP1, were determined by PCR or PCR-RFLP. The influence of the genetic polymorphisms on patient survival was estimated using the method of Kaplan-Meier survival function and Cox proportional hazards models. Results: The mean survival times (months) of the GSTP1 Ile/Ile, Ile/Val, and Val/Val were 11, 10, and 7, respectively (P < 0.05). The more the patients carried GSTP1 variant Val alleles, the poorer the survival rate (adjusted hazard ratio,1.36; 95% confidence interval,1.01-1.84; P trend = 0.045). In contrast, no association of GSTT1 or GSTM1 genotypes with survival rate was noted. Conclusion:The presence of the GSTP1 variant allele (Val) is associated with a poorer prognosis of esophageal cancer.

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“…Although several studies have been undertaken to examine the association between susceptibility to some type of cancer (Morita et al 1998;Tan et al 2000;Lee et al 2000;De Bruin et al 2000) and genetic polymorphism in GSTs, there are limited data on their association with reflux esophagitis (Liu et al 2006). The aim of this study was to analyze associations of the GST polymorphisms with reflux esophagitis and BE, and their interactions with smoking status and H. pylori infection in influencing the susceptibility to develop these complications of GERD in the Czech population.…”

Section: Introductionmentioning

confidence: 97%

Polymorphisms of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett’s esophagus

et al. 2007

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Reflux esophagitis (RE) and Barrett's esophagus (BE) belong to the most common esophageal complications of gastroesophageal reflux disease. Glutathione S-transferase (GST) enzymes play an important role in cellular protection against oxidative stress and toxic foreign chemicals. Therefore, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes could influence susceptibility to RE and BE. GSTM1, GSTT1 and GSTP1 loci were analyzed by PCR-based methods in 64 patients with RE (and an additional group of 22 subjects with BE as the fourth grade of esophagitis) and 173 unrelated controls. There were no significant differences in the distributions of GSTM1 and GSTT1 genotypes between the controls and patients with RE or BE. Similarly, frequencies of GSTP1 alleles were non-significantly different between the control and RE groups. However, GSTP1 B allele carriers were more frequent among the patients with BE compared to those in the reflux esophagitis group (P = 0.04, OR = 2.10, 95% CI 0.99-4.44) and most significantly when compared to the controls (P = 0.0067, P corr < 0.05, OR = 2.56, 95%CI 1.30-5.05). Although the GSTM1 and GSTT1 genes did not show any relationship with reflux disease, the GSTP1 gene might be one of the risk factors associated with susceptibility to RE, especially to BE.

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Genetic polymorphisms ofp53 andGSTP1,but notNAT2,are associated with susceptibility to squamous-cell carcinoma of the esophagus

Cited by 98 publications

References 45 publications

Association of genetic polymorphisms in MDM2, PTEN and P53 with risk of esophageal squamous cell carcinoma

Association of genetic polymorphisms in MDM2, PTEN and P53 with risk of esophageal squamous cell carcinoma

Association of GSTP1 Polymorphism and Survival for Esophageal Cancer

Polymorphisms of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett’s esophagus

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