Genetic predictors of vascular complications in adolescents involved in sports

Strozenko, L.A.; Snigir, O. A.; Lobanov, Yuriy F.; Скударнов, Е. В.; Ponomarev, Viktor S.; Miller, V.E.

doi:10.18821/1560-9561-2020-23-4-240-247

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…В связи с этим можно полагать, что полиморфные замены в минорных аллелях генах фолатного цикла из поколения в поколение возрастают, что сопровождается накоплением генетического груза, который в совокупности со сниженным уровнем ФК у детей способствует повышению уровня ГЦ в крови. Количественное увеличение мутаций ферментов фолатного цикла, свидетельствующее об усилении генетической нагрузки на современных детей, приводит к повышению содержания ГЦ в крови и может определять снижение качества жизни подростков[19,28]. У 80% обследованных подростков нами выявлено увеличение содержания ГЦ в крови.…”

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Polymorphic substitutions in folate cycle genes as predictors of hyperhomocysteinemia in children

Strozenko,

Ponomarev,

Lobanov

et al. 2024

RPJ

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Introduction. Mutant alleles of genes of folate cycle enzymes can lead to the significant deterioration of its function and varying severity of pathology. Several defects in these genes lead to severe hyperhomocysteinemia, the most common form of which is a deficiency of cystathionine beta-synthase B. Aim: to establish polymorphic substitutions in the genes of folate cycle enzymes that contribute to the formation of hyperhomocysteinemia in children. Materials and methods. Two hundred seventy one children aged of 13–18 years were examined. The analysis of genetic polymorphisms of the folate cycle was carried out using a molecular genetic method. Quantitative determination of the blood homocysteine and folic acid level was performed by chemiluminescent immunoassay on microparticles. Statistical data processing was carried out using Statistica 6.1 application programs (StatSoft Inc., USA). Results. The frequency of the T allele of the MTHFR 677 gene was revealed to be higher in adolescents of the main group compared with the control (p = 0.043). The frequency of the homozygous genotype 66 AA of the MTRR gene in children of the comparison group was significantly higher (p = 0.049), however, the heterozygous genotype 66 AG of the MTRR gene was significantly more often detected in adolescents of the main group (p = 0.008). The average concentrations of homocysteine in children of the main group were 11.6 mmol/L, in adolescents of the control group 9.3 mmol/L (p = 0.021). Hyperhomocysteinemia in children of the main group was detected in 217 (80.1%) adolescents, and in 57 (49.6%) children of the control group (p < 0.001). The baseline serum folate level was determined in the children of the main group. The average amount of vitamin B9 in the blood of children of the main group was 3.7 ng/ml, and in 145 (53.5%) children this indicator was significantly reduced. Conclusion. Low levels of folic acid contribute to an increase in homocysteine in blood plasma. Taking vitamin B9 and vitamin folate complexes significantly reduces the level of homocysteine in blood plasma (p < 0.001).

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Polymorphic substitutions in folate cycle genes as predictors of hyperhomocysteinemia in children

Strozenko,

Ponomarev,

Lobanov

et al. 2024

RPJ

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Assessment of the physical development of children with and without high thrombogenic risk factors in the Health Center for Children

Elizarieva,

Galaktionova,

Strozenko

et al. 2023

HERALD of North-Western State Medical University named after I.

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BACKGROUND: Up to 65% diseases associated with pathological thrombus have been described; more than 100 thrombogenic risk factors leading to vascular accidents have been studied. It is known that physical development is an important indicator of health in children. The relationship between the presence of thrombogenic risk factors in various disorders of physical development in children has been studied. AIM: To determine the relationship between physical development disorders in children and the presence of thrombogenic risk factors. MATERIALS AND METHODS: The study included 396 children aged 14–18 years, who underwent physical growth assessment using the sigma deviation method and genetic testing to determine polymorphisms of folate cycle genes and polymorphisms of thrombophilia genes. Statistical processing was carried out using the application package Statistica 10.0 (StatSoft, Inc., USA). RESULTS: The analysis of anthropometric indicators in children showed that in the group of the patients with thrombogenic risk factors, height and body weight values with average physical disharmonious development due to excess weight were statistically significantly higher than age-reference indicators. CONCLUSIONS: Based on the results of the study, it has been shown that disharmony in physical development in children with high thrombogenic risk factors may be one of the risk factors for the development of thrombotic conditions.

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Screening of thrombogenic risk factors in children in the Altai krai

Ponomarev

Скударнов

Strozenko

et al. 2023

RPJ

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Introduction. One of the urgent problems of modern pediatrics is the risk of developing vascular complications in children, among which thrombosis is not uncommon. For early diagnosis and thromboprophylaxis of strokes and other vascular complications, the identification of thrombogenic risk factors is indicated. The purpose of the study. Based on the screening, to establish predictors of thrombogenic risk in children living in urban and rural areas of the Altai Territory for the timely prevention of vascular complications. Materials and methods. The results of a screening study of two hundred seventeen aged 12–17 years children living in the city of Barnaul, Zarinsk and Klyuchevsk districts of the Altai Territory, were analyzed. Screening examination of children without signs of thrombosis and bleeding was carried out at an outpatient appointment with a pediatrician in random sampling. The questionnaire included questions to clarify the family thrombotic history, personal thrombotic history, background somatic diseases. Clinical examination was performed for all interviewed patients. Results. According to the results of the study, it was revealed that in 65 (30%) of the 217 children surveyed, the closest relatives had thrombogenic risk factors, such as heart attacks, strokes, hypertension, coronary heart disease (CHD). After analyzing the personal thrombotic history, it was found that in the general group of patients, myocardial infarction was observed in 2 (0.9%) children. Strokes were noted in 5 (2.3%) respondents, and thrombosis and TIA in 2 (0.9%) subjects. When analyzing the results, it was found that a significant proportion of children had the following conditions, such as vegetative-vascular dystonia (VVD) of the hypertensive type, the presence of signs of undifferentiated connective tissue dysplasia (UCTD), smoking, obesity. Conclusion. According to screening data in children, the main predisposing factors in the development of thrombosis, strokes and heart attacks are a burdened family, thrombotic history, the presence of some somatic diseases. The combination of these factors justifies the need for additional examination for the prevention of vascular thrombosis.

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Genetic predictors of vascular complications in adolescents involved in sports

Cited by 3 publications

References 13 publications

Polymorphic substitutions in folate cycle genes as predictors of hyperhomocysteinemia in children

Polymorphic substitutions in folate cycle genes as predictors of hyperhomocysteinemia in children

Assessment of the physical development of children with and without high thrombogenic risk factors in the Health Center for Children

Screening of thrombogenic risk factors in children in the Altai krai

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