Genetic Predisposition of Anti-Cytomegalovirus Immunoglobulin G Levels and the Risk of 9 Cardiovascular Diseases

Tan, Jiang-Shan; Ren, Jiameng; Fan, Luyun; Wei, Yuhao; Hu, Song; Zhu, Sheng-Song; Yang, Yanmin; Cai, Jun

doi:10.3389/fcimb.2022.884298

Cited by 23 publications

(19 citation statements)

References 72 publications

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“…At last, some studies suggest that race and ethnicity play a role in the risk of VTE. 48 49 50 It is reported that the mutations in the genes encoding anticoagulants are the main genetic cause of PE in Asia. 49 However, these mutations can only account for 12.04% of VTE patients.…”

Section: Discussionmentioning

confidence: 99%

Genetic Predisposition of Both Waist Circumference and Hip Circumference Increased the Risk of Venous Thromboembolism

et al. 2022

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Background: Obesity, especially abdominal obesity, is an independent indicator of increased cardiovascular risk. Observational studies have shown an observational association between obesity and venous thromboembolism (VTE). As a type of VTE, pulmonary embolism (PE) is also associated with obesity. But it is unclear whether the observed associations are causal or caused by confounding bias or reverse causality. Methods: We performed a two-sample by obtaining the exposure data set of WC and HC from the Neale Lab Consortium’s genome-wide association study (GWAS) summary data and the summary-level outcome data of VTE and PE from FinnGen Biobank of European ancestry to determine the causal effect of WC and HC on VTE and PE. Results: All three Mendelian Randomization (MR) methods displayed a positive association between WC/HC and VTE/PE. WC and HC were positively associated with VTE [odds ratio(OR)= 1.803 per 1 standard deviation(SD) increase in WC, 95% confidence intervals(CI) = 1.393-2.333; P< 0.001; OR = 1.479 per 1SD increase in HC, 95% CI = 1.219-1.796; P< 0.001, respectively]. Furthermore, we found a causal association between genetically predicted WC/HC and higher risk of PE (OR=1.929 per 1SD increase in WC, 95% CI=1.339-2.778, P < 0.001; OR=1.431 per 1SD increase in HC, 95% CI =1.095-1.869; P = 0.009, respectively). Conclusion: There is a significant causal relationship between WC/HC and VTE/PE, which is consistent with observational studies. Taking measures to reduce WC/HC of obesity may help reduce the incidence of VTE/PE.

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Section: Discussionmentioning

confidence: 99%

Genetic Predisposition of Both Waist Circumference and Hip Circumference Increased the Risk of Venous Thromboembolism

et al. 2022

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“…The primary analysis was inverse variance weighted (IVW) MR under a random-effect model, which assumed all genetic variants as valid instruments. Weighted median and MR-Egger methods were also performed [ 14 , 15 ]. The weighted median method can reveal consistent estimates even if up to 50% of the weight in the MR analysis comes from invalid genetic variants [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Causal Associations between Paternal Longevity and Risks of Cardiovascular Diseases

Wang

Tan

et al. 2022

JCDD

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Background: Observational studies have suggested that paternal longevity is associated with reduced risks of cardiovascular diseases, yet the causal association remains to be determined. Objectives: To investigate whether Mendelian randomization (MR) results support a causal role of paternal longevity for risks of cardiovascular diseases. Methods: Genetic variants associated with paternal longevity and cardiovascular diseases were obtained from public genome-wide association study data. We used inverse variance weighted MR under a random-effects model to provide causal estimates between paternal longevity and cardiovascular diseases. Results: Paternal longevity was associated with decreased risks of coronary heart disease (odds ratio (OR): 0.08; 95% confidence interval (CI): 0.02–0.37; p = 0.001) and peripheral artery disease (OR: 0.15; 95% CI: 0.03–0.65; p = 0.011). No significant differences were observed in hypertension, atrial fibrillation, heart failure, transient ischemic attack, ischemic stroke, or cardiac death. The weighted median method revealed consistent results between genetically instrumented paternal longevity and decreased risk of coronary heart disease and peripheral artery disease. No significant differences were observed in the MR-Egger results. Multivariable MR consistently indicated causal associations between paternal longevity and decreased cardiovascular diseases. The leave-one-out analysis suggested that the causal associations were not affected by individual single-nucleotide polymorphisms. The intercept of the MR-Egger estimator and funnel plot revealed no indication of horizontal pleiotropic effects. Conclusions: Our MR analyses supported a causal role of paternal longevity for decreased risks of coronary heart disease and peripheral artery disease, which highlighted the need for better monitoring and intervention of cardiovascular diseases in populations with premature paternal death.

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“…All of our data were obtained from published studies, which were supported by the institutional review committee, and informed consent was obtained from the participants in their original research [ 27 , 28 ]. Thus, further sanctions were not needed.…”

Section: Data Availability and Ethical Approvalmentioning

confidence: 99%

Genetically predicted obesity and risk of hip osteoarthritis

Yuan

Wang²,

Zhang

et al. 2023

Eat Weight Disord

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Objectives To determine the causal association between genetically predicted obesity and the risk of hip osteoarthritis. Methods We performed two-sample Mendelian randomization (MR) analysis to analyze the association between body mass index (BMI) and hip osteoarthritis using pooled-level genome-wide association study (GWAS) data. The inverse variance weighted (IVW), MR‒Egger, and weighted median methods were used to estimate the causal association. In addition, we applied the MR Steiger filtering method, MR robust adjusted profile score (MR.RAPS) methods, and the MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) global test to examine and address potential horizontal pleiotropy. Results We found a causal relationship between genetically predicted BMI and the risk of hip osteoarthritis by the IVW method [OR = 1.45, 95% confidence interval (CI) = 1.04–2.00, P = 0.02]. In the sensitivity analysis, the results of the MR‒Egger and weighted median methods revealed similar estimations but with a wide CI with lower precision. The funnel plot, MR–Egger intercept, and MR-PRESSO all indicated the absence of a directional pleiotropic effect. In addition, no heterogeneity was observed in the present analysis. Therefore, the result of IVW is most suitable and reliable for the present MR analysis. Conclusion There is a causal relationship between obesity and a higher risk of hip osteoarthritis, suggesting that weight management may be an intervention for the prevention and management of hip osteoarthritis. Level of evidence Bioinformatics, Basic science.

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Genetic Predisposition of Anti-Cytomegalovirus Immunoglobulin G Levels and the Risk of 9 Cardiovascular Diseases

Cited by 23 publications

References 72 publications

Genetic Predisposition of Both Waist Circumference and Hip Circumference Increased the Risk of Venous Thromboembolism

Genetic Predisposition of Both Waist Circumference and Hip Circumference Increased the Risk of Venous Thromboembolism

Causal Associations between Paternal Longevity and Risks of Cardiovascular Diseases

Genetically predicted obesity and risk of hip osteoarthritis

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