2024
DOI: 10.1097/wco.0000000000001263
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Genetic predisposition to autoimmune encephalitis and paraneoplastic neurological syndromes

Sergio Muñiz-Castrillo,
Jérôme Honnorat

Abstract: Purpose of review We summarize the recent discoveries on genetic predisposition to autoimmune encephalitis and paraneoplastic neurological syndromes (PNS), emphasizing clinical and pathophysiological implications. Recent findings The human leukocyte antigen (HLA) is the most studied genetic factor in autoimmune encephalitis and PNS. The HLA haplotype 8.1, which is widely known to be related to systemic autoimmunity, has been only weakly associated with … Show more

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Cited by 4 publications
(2 citation statements)
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“…In Olmsted County, Minnesota, the incidence of autoimmune encephalitis increased over time from 0.4/100,000 person-years (1995-2005) to 1.2/100,000 person-years (2006-2015), comparable with the incidence of infectious encephalitis, and African American people were disproportionately affected 5 . Pacific Islander, Māori, or Asian background appears to be a risk factor for NMDA receptor encephalitis, 6 whereas leucine-rich glioma inactivated protein 1 (LGI1) encephalitis is found predominantly in White and Asian individuals 7 . The increase in the incidence of autoimmune encephalitis is attributable to increased detection of people who are antibody positive 5 .…”
Section: Epidemiology and Risk Factorsmentioning
confidence: 95%
See 1 more Smart Citation
“…In Olmsted County, Minnesota, the incidence of autoimmune encephalitis increased over time from 0.4/100,000 person-years (1995-2005) to 1.2/100,000 person-years (2006-2015), comparable with the incidence of infectious encephalitis, and African American people were disproportionately affected 5 . Pacific Islander, Māori, or Asian background appears to be a risk factor for NMDA receptor encephalitis, 6 whereas leucine-rich glioma inactivated protein 1 (LGI1) encephalitis is found predominantly in White and Asian individuals 7 . The increase in the incidence of autoimmune encephalitis is attributable to increased detection of people who are antibody positive 5 .…”
Section: Epidemiology and Risk Factorsmentioning
confidence: 95%
“…5 Pacific Islander, Māori, or Asian background appears to be a risk factor for NMDA receptor encephalitis, 6 whereas leucine-rich glioma inactivated protein 1 (LGI1) encephalitis is found predominantly in White and Asian individuals. 7 The increase in the incidence of autoimmune encephalitis is attributable to increased detection of people who are antibody positive. 5 The incidence of paraneoplastic neurologic syndromes in Olmsted County, Minnesota increased over time from 0.4/100,000 person-years (1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002) to 0.8/100,000 person-years (2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)).…”
Section: Epidemiology and Risk Factorsmentioning
confidence: 99%