Genetic Predisposition to Autoimmunity Implications for Rheumatoid Arthritis

Shiozawa, Shunichi; Tsukamoto, Yasuo; Hayashi, Sachiko; Shiozawa, Kazuko

doi:10.1097/00124743-199806000-00013

Cited by 2 publications

(3 citation statements)

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“…This tendency is by no means healthy from the view of the science associated with human health and disease. We have, therefore, invented our own computer program which faithfully follows the technique of Holmans and Clayton [5], and our results have been published elsewhere [3,4,6,7]. Importantly, the results obtained using our computer program coincide nicely with the results obtained through Mapmaker/sibs.…”

Section: Sib-trio Marker Typesupporting

confidence: 54%

“…It is desirable to utilize the probability p a for the marker a obtained by the population in geographically widespread area; however, in this case, p a was estimated via the set of unaffected sibs to obtain total family data. According to previous studies [3,4], more precise analyses using microsatellite DNA sizing were performed on the loci DXS1047, DXS8072, DXS8041, DXS8094, DXS1192, DXS984, DXS1205, DXS1227, DXS8106, DXS8043, and DXS8028. The results of MLS analysis for each locus are Table 4 Likelihood ratio for (sister,sister),sister (0 B z 1ss B 1/2)…”

Section: Discussionmentioning

confidence: 99%

“…They can be applied to many common diseases with unidentified inheritance; for example, to a genome-wide search for disease susceptibility genes in rheumatoid arthritis [3,4]. Such methods utilize sets of information on the genotypes of an affected sib-pair and their parents.…”

Section: Introductionmentioning

confidence: 99%

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Mathematical basis of affected sib-pair analysis: an extension to X-linked loci

et al. 2010

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Most clinical genetic studies are done without knowing their mathematical basis. However, because the results of such studies rely on the correctness of the mathematical calculations involved, we cannot ignore the mathematics of genetic studies. In this study, the mathematical basis of the sib-pair method, which has been widely used in recent genome-wide studies, was extended to studies focusing on the X chromosome, and then applied to study a clinical microsatellite marker on the X chromosome. Our calculation involves classifying marker types on the X chromosome for an affected sib-pair and an unaffected sib, together with their sexual information and the possible parental marker types applicable to a genome-wide genetic study. The method proposed in this study was then applied to 41 Japanese rheumatoid families, and the locus DXS984 was found to be most likely to be linked with rheumatoid arthritis (RA). This locus, which we found nicely, was also highlighted in a previous study that used the Mapmaker/sibs program, so we can conclude that our calculation provides a solid foundation for understanding and confirming the results obtained using the sib-pair method.

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Section: Sib-trio Marker Typesupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%