Genetic Predisposition to<i>Bacillus piliformis</i>Infection among Mice

Gowen, John W.; Schott, Ralph G.

doi:10.1017/s0022172400018672

Cited by 17 publications

(8 citation statements)

References 8 publications

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“…This statement by Gard concerning the sporeforming bacterium (Bacillus piliformis) which multiplies only within certain cells seems as appropriate today as 26 yr ago. Numerous reports (4,9,15,19) have confirmed Tyzzer's original description (20) of a fatal enteric disease of mice, since known as Tyzzer's disease. The diagnostic feature of Tyzzer's disease is the demonstration of bundles of gram-negative, pleomorphic bacilli (B. piliformis) randomly arranged in the cytoplasm of apparently viable liver cells which border small areas of coagulation necrosis.…”

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confidence: 77%

Tyzzer's Disease of Rabbits: Isolation and Propagation of Bacillus piliformis (Tyzzer) in Embryonated Eggs

1971

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Bacillus piliformis (Tyzzer) was isolated from the liver of rabbits with Tyzzer's disease and serially passaged in embryonated hens' eggs. Weanling rabbits given the 32nd egg passage developed lesions typical of Tyzzer's disease and died. B. piliformis was reisolated from the liver of these rabbits in embryonated eggs. Outside the host cell, the motile vegetative phase appeared to be unstable, and no means was found to preserve its viability; the results of titrations were believed to be dependent upon the resistant stage or spore. The spore withstood repeated freeze and thaw and was resistant to heat treatment of 56 C for 1 hr but not 80 C for 0.5 hr. None of several antibacterial substances tested in embryonated eggs was completely inhibitory; B. piliformis was resistant to sulfamethazine and chloramphenicol. The taxonomic position of this pleomorphic, gram-negative, sporeforming, pathogenic bacterium which appears to grow only in certain cells of several species remains unresolved.

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confidence: 77%

Tyzzer's Disease of Rabbits: Isolation and Propagation of Bacillus piliformis (Tyzzer) in Embryonated Eggs

1971

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“…The demonstration that some strains of animals are resistant and others susceptible to infection by a given strain of micro-organism has been known for many years (Lewis and Loomis, 1928;Gowen and Schott, 1933) and several mechanisms have been proposed to explain this phenomenon (Eastwood, 1927). Particular strains of mice that differ in susceptibility to infection by S. typhimurium have been known for some time (Gorer and Schutze, 1938) and it has been suggested that genetically determined resistance might operate through the presence of opsonising antibodies which enhance clearance of S. typhimurium from the circulation of infected animals (Rowley and Jenkin, 1962).…”

Section: Discussionmentioning

confidence: 99%

Crossreactivity as a Factor in the Immune Response to Salmonella Typhimurium in Cba and Balb/C Mice

Wooley¹,

Ebringer

1980

Journal of Medical Microbiology

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“…The meiotic peculiarities described for claret of D. simulans are seemingly under genic control. In D. melanogaster the important instances of apparent genic control of nondisjunction and chromosome loss are those reported for claret-nondisjunctional (LEWIS and GENCARELLA 1952) and for C3G (GOWEN 1933).…”

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confidence: 86%

Genic Control of Chromosome Loss and Nondisjunction in Drosophila Melanogaster

Spieler

1963

Genetics

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HROMOSOME nondisjunction, the failure of the members of a chromosome 'pair to separate to the two daughter nuclej, was first described by BRIDGES (1913,1916). Theoretically, nondisjunction of the X chromosomes in XX females should result in the production of equal numbers of nullo-X and diplo-X gametes. Consequently, the two resulting classes of viable exceptional off spring, patroclinous sons and matroclinous daughters (presumably XO and XXY, respectively), should be recovered in statistically equal numbers. It was soon realized, however, that other events partially mimic the consequences of nondisjunction by giving rise to patroclinous sons but differ in yielding no matroclinous daughters. In the extensive data of SAPIR (1920) patroclinous sons were found to be about four times as frequent as matroclinous daughters. A much greater disparity observed in a particular strain of Drosophila mehogaster (SPIELER 1961) led to the investigations described in the present paper.An excess of patroclinous males would seem to be due to the recovery of more nullo-X eggs than diplo-X eggs. The unequal recovery could be caused by a variety of events which will be referred to generically as "chromosome loss.'' Chromosome loss will be said to occur whenever the ratio of patroclinous males to matroclinous females is significantly greater than one. This operational definition must be applied with caution, however, to those cases in which one might expect important viability differences to result from the relative mutational load of the maternal and paternal sex chromosomes.Although no attempt will be made to present an exhaustive list of the occurrences which may contribute to chromosome loss, a few will be mentioned briefly. One obvious possibility (which could take place at either meiotic division) would be separation of the X chromosomes followed by noninclusion of an X in one daughter nucleus. Or, after nondisjunction has occurred, there may be a directed orientation of the four meiotic products such that a nullo-X nucleus, rather than a diplo-X nucleus, more often becomes the egg pronucleus. Also, heterozygous X-chromosomal inversions produce nullo-X eggs by four-strand double exchange within the inversions ( STURTEVANT and BEADLE 1936) or by three-strand double exchange, one exchange within the inversion and one outside Statistical Methods. Iowa State College Press. Ames, Iowa. Nondisjunction involving the maroon-like and rosy mutants of Drosophila Accuracy of mutation rates. J. Genet. 43: 301-307.melanogaster.

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Genetic Predisposition toBacillus piliformisInfection among Mice

Cited by 17 publications

References 8 publications

Tyzzer's Disease of Rabbits: Isolation and Propagation of Bacillus piliformis (Tyzzer) in Embryonated Eggs

Tyzzer's Disease of Rabbits: Isolation and Propagation of Bacillus piliformis (Tyzzer) in Embryonated Eggs

Crossreactivity as a Factor in the Immune Response to Salmonella Typhimurium in Cba and Balb/C Mice

Genic Control of Chromosome Loss and Nondisjunction in Drosophila Melanogaster

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