Genetic profile of 17 Y-chromosome STR haplotypes in East of Iran

Tabrizi, Arash Alipour; Hedjazi, Arya; Kerachian, Mohammad Amin; Honarvar, Zohreh; Dadgarmoghaddam, Maliheh; Raoofian, Reza

doi:10.1016/j.fsigen.2014.10.010

Cited by 9 publications

(15 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lower HD obtained for Mazandaran demonstrates that there has been less migration to this province; on the other hand, the male population in this province is isolated. The calculated DC in Gilan was higher than the previously reported DC in Tehran (DC = 0.9), Isfahan (DC = 0.938 and DC = 0.95) (11,14), and the eastern population of Iran (DC = 0.9884) (12), which illustrates the capability of these markers for male identity in this province. However, the DC value in Mazandaran was higher than the one in other provinces except for eastern provinces including Razavi Khorasan, South Khorasan, and Sistan and Baluchestan.…”

Section: Discussioncontrasting

confidence: 68%

“…63 Gilan 15 14 31 24 10 13 14 22 10 12 14 21 13 18 21 64 Gilan 13 29 23 10 11 12 12 17 9 12 15 21 15 23 65 Gilan 13 13 31 24 10 11 12 12 9 10 15 19 15 19 24 66 Gilan 15 13 30 25 10 10 13 11 14 11 10 14 20 15 19 23 67 Gilan 13 29 25 10 13 12 11 14 12 14 14 19 15 15 23 68 Gilan 14 13 29 23 10 11 12 13 17 10 12 14 20 14 20 69 Gilan 14 12 28 23 10 11 13 13 17 9 13 15 21 15 15 22 70 Gilan 14 13 30 10 11 13 12 10 11 14 19 15 20 20 71 Gilan 14 12 28 23 11 11 12 12 17 12 15 22 16 15 21 72 Gilan 16 13 30 22 10 11 14 12 20 10 12 14 20 17 Amplification of all Y-STRP markers signifies the efficiency of these markers for forensic and molecular investigation of the Y-chromosome in the north of Iran. Haplotype analysis via 17 Y-STRP markers of 259 males from eastern provinces of Iran showed HD = 0.9999 (12). This value was declared to be 0.997 in Tehran and Isfahan provinces by analyzing 9 Y-STRP markers (11).…”

Section: Discussionmentioning

confidence: 93%

“…Amplification of all Y-STRP markers signifies the efficiency of these markers for forensic and molecular investigation of the Y-chromosome in the north of Iran. Haplotype analysis via 17 Y-STRP markers of 259 males from eastern provinces of Iran showed HD = 0.9999 (12). This value was declared to be 0.997 in Tehran and Isfahan provinces by analyzing 9 Y-STRP markers (11).…”

Section: Discussionmentioning

confidence: 93%

“…Iran, a large country with more than 80 million people, consists of several ethnic groups, and needs its own ethnic-specific databases for allele frequencies and heterogeneity of STRP markers. Although the eastern and central regions have been studied previously (11)(12)(13)(14), there is not much information on Y-STRP markers and haplotype heterogeneity in the north of Iran. Therefore, in this project, we analyzed 17 Y-STRP markers in male populations in two northern populations of Iran via multiplex PCR and capillary electrophoresis following statistical analysis.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Profiling of 17 Y-STR loci in Mazandaran and Gilan provinces of Iran

et al. 2019

View full text Add to dashboard Cite

Background/aim: The Y-chromosome mainly consists of heterochromatin regions that have a father-to-son inheritance. Short tandem repeat polymorphic (STRP) markers distributed all over the chromosome provide the opportunity for investigations in forensic medicine and ancestral lineage studies. Due to the existence of wide varieties of geographical and ethnic groups in Iran, studying Y-STRP markers is necessary for further applications. Here we investigated the provinces of Mazandaran and Gilan for the first time. Materials and methods: Samples included 119 and 90 unrelated males from Mazandaran and Gilan, respectively. Using a PCR amplification kit, 17 Y-STRP markers were amplified and genotyping was conducted by capillary electrophoresis. Allele frequency, haplotype diversity (HD), and haplotype discrimination capacity (DC) were calculated. The populations were compared together and to neighboring countries including Afghanistan and Azerbaijan by F ST index. Results: A total of 204 unique haplotypes were observed. No uniqueness was observed between the two provinces. HD was 0.9993 and 0.9998 in Mazandaran and Gilan, respectively. DC was 0.9666 and 0.9888 for Mazandaran and Gilan, respectively. DYS385b and DYS391 had the most and least polymorphic content in both provinces, respectively. There was not a significant difference between these two provinces (F ST = 0.0006 and P = 0.00) and neighboring countries. Conclusion: The results highlight the effectiveness of these Y-STRP markers for male discrimination in the north of Iran. Using additional markers along with extended sample size would provide a better opportunity for removing matched haplotypes and introducing the best polymorphic markers in this specific population.

show abstract

Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Profiling of 17 Y-STR loci in Mazandaran and Gilan provinces of Iran

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Nonetheless, the results fail to concur with high gene diversity of DYS19 in studies of Y-STR conducted in the US, Iran, and Hispanic populations. 21 – 23 As such, more studies have to be conducted with more samples to ascertain whether this is just an exception for the markers or whether Orang Asli does possess lower diversity for DYS19. 5 Meanwhile, the other marker with small locus diversity value is DYS392, which is a trinucleotide marker.…”

Section: Resultsmentioning

confidence: 99%

Polymorphism of 11 Y Chromosome Short Tandem Repeat Markers among Malaysian Aborigines

Yussup

Marzukhi

Md-Zain

et al. 2017

Evol Bioinform Online

View full text Add to dashboard Cite

The conventional technique such as patrilocality suggests some substantial effects on population diversity. With that, this particular study investigated the paternal line, specifically Scientific Working Group on DNA Analysis Methods (SWGDAM)-recommended Y-STR markers, namely, DYS19, DYS385, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS438, and DYS439. These markers were tested to compare 184 Orang Asli individuals from 3 tribes found in Peninsular Malaysia. As a result, the haplotype diversity and the discrimination capacity obtained were 0.9987 and 0.9076, respectively. Besides, the most diverse marker was DYS385b, whereas the least was DYS391. Furthermore, the Senoi and Proto-Malay tribes were found to be the most distant, whereas the Senoi and Negrito clans were almost similar to each other. In addition, the analysis of molecular variance analysis revealed 82% of variance within the population, but only 18% of difference between the tribes. Finally, the phylogenetic trees constructed using Neighbour Joining and UPGMA (Unweighted Pair Group Method with Arithmetic Mean) displayed several clusters that were tribe specific. With that, future studies are projected to analyse individuals based on more specific sub-tribes.

show abstract

Forensic Human Y-Chromosome Markers: Principles and Applications

Tabrizi¹

2021

Handbook of DNA Profiling

View full text Add to dashboard Cite

Genetic profile of 17 Y-chromosome STR haplotypes in East of Iran

Cited by 9 publications

References 12 publications

Profiling of 17 Y-STR loci in Mazandaran and Gilan provinces of Iran

Profiling of 17 Y-STR loci in Mazandaran and Gilan provinces of Iran

Polymorphism of 11 Y Chromosome Short Tandem Repeat Markers among Malaysian Aborigines

Forensic Human Y-Chromosome Markers: Principles and Applications

Contact Info

Product

Resources

About