Genetic Profiling of the Nitric Oxide Synthases’ System in a 55-Year-Old Woman with the Tension-Type Headache and Arterial Hypertension Phenotype: Case Report
Abstract:The tension-type headache (TTH) and arterial hypertension (AH) phenotype is a common overlap syndrome in adult patients. A genetically determined disturbance of the nitric oxide (NO) synthesis system is actively considered as one of the important possible pathogenetic mechanisms for the development of this phenotype. Neuronal NO-synthase is expressed both in the brain, skeletal muscles, and in the vascular endothelium; therefore, single-nucleotide variants of the NOS1 gene, encoding this enzyme, are the most i… Show more
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