Genetic regulation analysis reveals involvement of tumor necrosis factor and alpha-induced protein 3 in stress response in mice

Xu, Jian; Dai, Aihua; Chen, Qi; Liu, Xiaorong; Wang, Hongmei; Li, Haizhen; Chen, Ying; Cao, Mei

doi:10.1016/j.gene.2015.10.071

Cited by 2 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TNFAIP3 is identified as a gene whose expression level is promptly induced by the tumor necrosis factor. It is a zinc finger protein and plays an important role in cytokine-me- diated immune and inflammatory responses [13,14]. Some studies have shown that TNFAIP3 acts an important tumor suppressor in several malignancies.…”

Section: Discussionmentioning

confidence: 99%

TNFAIP3 inhibits migration and invasion in nasopharyngeal carcinoma by suppressing epithelial mesenchymal transition

Huang¹,

Yin²,

Wu³

et al. 2017

neo

View full text Add to dashboard Cite

TNF alpha induced protein 3 (TNFAIP3), a member of zinc finger protein family, is a gene whose expression level is promptly induced by the tumor necrosis factor. In this study, the clinical significance of TNFAIP3 was analyzed based on available samples in The Cancer Genome Atlas database. TNFAIP3 downregulation was associated with distant metastasis and worse patient prognosis. TNFAIP3-overexpressing and TNFAIP3-knockdown NPC cell line models were established through plasmid-mediated overexpression and small interfering RNA (siRNA), respectively. Cell migration and invasion capacities were evaluated by wound-healing and transwell assays. Functional studies indicated that TNFAIP3 knockdown promoted migration and invasion, whereas TNFAIP3 overexpression alleviated these functions. Western blot analysis was used to examine protein changes from TNFAIP3 overexpression and knockdown, in which TNFAIP3 promoted the protein expression of E-cadherin and suppressed vimentin expression. Our data suggested that TNFAIP3 inhibited migration and invasion by suppressing epithelial mesenchymal transition in NPC.

show abstract

Section: Discussionmentioning

confidence: 99%

TNFAIP3 inhibits migration and invasion in nasopharyngeal carcinoma by suppressing epithelial mesenchymal transition

Huang¹,

Yin²,

Wu³

et al. 2017

neo

View full text Add to dashboard Cite

show abstract

“…For example, the expression of TNFAIP3 increased in mouse hippocampal tissue in response to chronic unpredictable mild stress [22]. In addition, patients with conditions that alter the level of TNFAIP3 mRNA tend to be more anxious than healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

TNFAIP3 mRNA Level Is Associated with Psychological Anxiety in Major Depressive Disorder

Chen

Huang

et al. 2017

Neuroimmunomodulation

View full text Add to dashboard Cite

Background: Major depressive disorder has been shown to be associated with inflammation and the dysregulation of innate immune responses. Previously, we showed an inverse correlation between the severity of depression and level of TNFAIP3 mRNA expression. The present study further evaluated the association between TNFAIP3 mRNA expression level and symptoms of major depressive disorder (MDD) in 91 patients (20 men and 71 women). Methods: The relationships between subscores on the 17-item Hamilton Depression Rating Scale (HAMD-17) and TNFAIP3 mRNA levels were assessed by multiple linear regression. Results: Only psychological anxiety on the HAMD-17 correlated significantly with TNFAIP3 mRNA expression. Other symptoms, such as depressed mood, insomnia, work and activities, and suicide, were not associated with TNFAIP3 mRNA expression. Conclusion: These findings suggest a significant association between anxiety and TNFAIP3 mRNA levels in patients with MDD.

show abstract

Genetic regulation analysis reveals involvement of tumor necrosis factor and alpha-induced protein 3 in stress response in mice

Cited by 2 publications

References 31 publications

TNFAIP3 inhibits migration and invasion in nasopharyngeal carcinoma by suppressing epithelial mesenchymal transition

TNFAIP3 inhibits migration and invasion in nasopharyngeal carcinoma by suppressing epithelial mesenchymal transition

TNFAIP3 mRNA Level Is Associated with Psychological Anxiety in Major Depressive Disorder

Contact Info

Product

Resources

About