Genetic Regulation of Emotion Brain Circuitries

López‐Muñoz, Francisco; Álamo, Cecilio

doi:10.1201/b11232-9

Cited by 2 publications

(3 citation statements)

References 95 publications

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“…If hypertension is high it can cause reflex bradycardia. Excessive and prolonged activation of the myocardium is dangerous; this could cause improper increased oxygen consumption and micro injuries that may appear in the vessels and myofibrils 10 .…”

Section: Introductionmentioning

confidence: 99%

Epinephrine in cardiac arrest: systematic review and meta-analysis

Morales‐Cané

Valverde-León

Rodríguez‐Borrego

2016

Rev. Latino-Am. Enfermagem

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Objective:evaluate the effectiveness of epinephrine used during cardiac arrest and its effect on the survival rates and neurological condition. Method:systematic review of scientific literature with meta-analysis, using a random effects model. The following databases were used to research clinical trials and observational studies: Medline, Embase and Cochrane, from 2005 to 2015. Results:when the Return of Spontaneous Circulation (ROSC) with administration of epinephrine was compared with ROSC without administration, increased rates were found with administration (OR 2.02. 95% CI 1.49 to 2.75; I2 = 95%). Meta-analysis showed an increase in survival to discharge or 30 days after administration of epinephrine (OR 1.23; 95% IC 1.05-1.44; I2=83%). Stratification by shockable and non-shockable rhythms showed an increase in survival for non-shockable rhythm (OR 1.52; 95% IC 1.29-1.78; I2=42%). When compared with delayed administration, the administration of epinephrine within 10 minutes showed an increased survival rate (OR 2.03; 95% IC 1.77-2.32; I2=0%). Conclusion:administration of epinephrine appears to increase the rate of ROSC, but when compared with other therapies, no positive effect was found on survival rates of patients with favorable neurological status.

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Section: Introductionmentioning

confidence: 99%

Epinephrine in cardiac arrest: systematic review and meta-analysis

Morales‐Cané

Valverde-León

Rodríguez‐Borrego

2016

Rev. Latino-Am. Enfermagem

View full text Add to dashboard Cite

show abstract

“…Centrally localised presynaptic ␣ 2 -AR, as auto-and/or heteroreceptors, play a crucial role in the regulation of monoamine neurotransmitter (NA, dopamine and serotonin) release from nerve terminals by negative feedback mechanism [14,33]. Consequently they are implicated in several disease pathologies of the CNS including psychiatric disorders such as major depression [9,26]. Indeed, the ␣ 2 -AR antagonist mirtazapine is used clinically as an antidepressant [7,21].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, the ␣ 2 -AR antagonist mirtazapine is used clinically as an antidepressant [7,21]. In addition, several lines of evidence indicate that pathophysiology of depression is associated with dysregulation of central ␣ 2 -AR [6,26]. Studies of ␣ 2 -AR with radiolabelled agonists, but not antagonists, on platelets from depressed patients and human postmortem brain tissue obtained from depressed/suicide victims, repeatedly showed selective upregulation of ␣ 2 -AR [4,10,12,20], along with enhanced G-protein coupling and receptor activity [16,40].…”

Section: Introductionmentioning

confidence: 99%