Genetic regulation of immunoglobulin synthesis

Oudin, J

doi:10.1002/jcp.1040670409

Cited by 103 publications

(27 citation statements)

References 101 publications

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“…Among the antigenic specificities of several kinds that are distinguished in immunoglobulins, the isotypic and allotypic specificities apparently reflect differences in primary structures (6,7). It seems reasonable to assume that the same is true for idiotypic specificities, and in addition, that the structural differences concerned in the latter case are located in the variable regions of the polypeptide chains.…”

Section: Speculation On the Relationship Of Idiotypy To The Primary Smentioning

confidence: 99%

“…Its serum, taken before the latter immunization, was no longer precipitated by the antiidiotypic serum against its anti-S, typhi antibodies. The serum samples taken after the immunization against S. typhimurium were precipitated by the same 6 We want to thank Doctor L. Le Minor, chef du Service des Enterobact~riac~es de l'Institut Pasteur, to whom is due the choice and supply of a Salmonella fulfilling these requirements: S. tranoroa (22).…”

Section: Comparison Of the Idiotypic Specific Ties O] The Antibodies mentioning

confidence: 99%

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Idiotypy of Rabbit Antibodies

Oudin

Michel

1969

The Journal of Experimental Medicine

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108

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Idiotypy shares with allotypy the characteristic that antigenic specificities proper to it in one category of proteins, as one given class of immunoglobulins, are not carried by the protein molecules of this category in all the individuals of the same animal species. But, in contrast to allotypy which has been observed in several other kinds of proteins after its discovery among immunoglobulins, idiotypy is by definition restricted to antibodies.One of the most two important features of idiotypy--also the most striking difference between idiotypy and immunoglobulin allotypy--is that an idiotypic specificity found in antibodies against one given antigen has been found neither in the serum of the nonimmunized animal, nor in antibodies against another, noncrossreacting antigen. It was this striking difference that first made the authors conscious that what they observed in rabbits was definitely different from conventional allotypy (1).A second important feature of idiotypy, which contrasts also with conventional allotypy, is that each idiotypic spedfieity, carried by antibodies of one given rabbit against Salmonella typki, has not been found yet (at least not exactly under the same form) in antisera of other rabbits against the same antigenic material, x * Aided by a grant (67-00-605) of the Deq~gation G~n&ale ~ la Recherche Scientifique e t Technique (Comit~ de Biologic Mol&-ulaire).x The reluctance of the authors to propose a new term for the new phenomenon before being quite sure that this was necessary made them present their first results as a peculiar kind of allotypy in which each allotypic specificity would be restricted (a) to a single antibody, and (b) to a single individual. Actually, the newly observed phenomenon was fundamentally different from aUotypy, and the use of the same term for both would have been extremely confusing in the necessarily elaborate discussions which involve the three different kinds of antigenic specificities carried by the same immunoglobulin molecule (i.e. isotypic, allotypie, and idiotypic specificities). Consequently, it was found necessary to coin a new word of the same family as those proposed in 1956 (2) and in 1960 (3, 4, 5). In the same way as in "allotypic" or "isotypic," where "typic" (from rwro~, print or type) stands for antigenic specificity, "allo" (from tXko~, other) stands for different, and "iso" (from ~ros, the same) stands for similar, "idiotypic" was proposed (6, 7). The first part of the word (idio, from ~8~o,, peculiar) is justified by the extreme peculiarity of the antigenic specificities in question. An idiotype is a peculiar kind of protein antigen defined by its idiotypic specificity. In this paper, we will 595 on

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Section: Speculation On the Relationship Of Idiotypy To The Primary Smentioning

confidence: 99%

Section: Comparison Of the Idiotypic Specific Ties O] The Antibodies mentioning

confidence: 99%

Idiotypy of Rabbit Antibodies

Oudin

Michel

1969

The Journal of Experimental Medicine

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108

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“…(Received for publication 27 September 1972) In the rabbit, b locus allotypic determinants present on kappa-type light chains have been demonstrated both on circulating immunoglobulins (1,2) and on the membrane-associated immunoglobulins of bone marrow-derived (B) 1 lymphocytes (3)(4)(5)(6). The production of circulating b5 immunoglobulin (Ig) can be suppressed by exposing rabbits in utero or at birth to anti-b5 antisera (allotype suppression) (7)(8)(9)(10).…”

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confidence: 99%

DELETION OF b5 IMMUNOGLOBULIN-BEARING LYMPHOCYTES IN ALLOTYPE-SUPPRESSED RABBITS

Harrison

Mage

Davie

1973

The Journal of Experimental Medicine

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The proportion of peripheral blood lymphocytes with cell surface b5 immunoglobulin (Ig) was compared with serum b5 Ig levels in allotype-suppressed and recovering b5 homozygous rabbits in order to establish the cellular defect in suppression and to determine the relation between lymphocyte membrane Ig and secreted Ig of the same allotype. In rabbits fully suppressed for b5, the absence of circulating b5 Ig is reflected in a complete deletion of b5-bearing lymphocytes. During spontaneous escape from suppression, the appearance of b5-bearing lymphocytes precedes the appearance of detectable serum b5. During recovery from suppression b5-bearing lymphocytes recover rapidly toward normal levels, but circulating b5 levels remain chronically and disproportionately depressed.

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“…This idiotypic variation has been studied extensively in mice and rabbits. As early as 1963, antigenic determinants located on V regions of rabbit IgH chains were found (10). Pedigree analysis of rabbits homozygous for two different VH region allotypes demonstrated that VH and CH region allotypes were linked, although recombinants were observed (11).…”

mentioning

confidence: 99%

Polymorphisms of a human variable heavy chain gene show linkage with constant heavy chain genes.

Johnson¹,

Natali²,

Cann³

et al. 1984

Proc. Natl. Acad. Sci. U.S.A.

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In this study, restriction fragment length polymorphisms (RFLPs) were identified with an immunoglobulin variable heavy chain region (Ig VH) probe and the inheritance of the polymorphisms was analyzed in families. Linkage within the VHII gene cluster and between the VHII and Ig CH genes was investigated by lod (logarithm of odds) score analysis. In addition, the position of the VHII genes was determined in relation to another polymorphic locus-D14S1, which is tightly linked and centromeric to the CH genes. Genetic associations between genes in the CH and VH clusters were analyzed.These RFLPs represent genetically characterized VH region polymorphisms and it is hoped that they will facilitate the study of disease correlations as well as further the understanding of the genetics of the immunoglobulin heavy chain genes in humans.The immunoglobulins consist of four polypeptide chains, two heavy (H) and two light (L), each of which contains a variable (V) region-encoded amino terminus covalently attached to a constant (C) region-encoded carboxyl terminus. The V region polypeptides can be divided into functional segments categorized as framework regions (FR1-4) and hypervariable or complementarity-determining regions (CDR1-3). Each VH polypeptide is composed of sequences encoded by three different genetic elements. These are (i) V region sequences coding for amino acids 1-98, which form FR1-3 and CDR1 and CDR2; (it) diversity (D) region sequences coding for amino acids 99-103, which form CDR3; and (iil) joining (J) region sequences coding for amino acids 103-110, forming FR4 (1-3). A rearranged VH sequence can be recombined subsequently to the 5' end of any CH subclass region sequence by a process known as class switching (4), which illustrates that a single VH gene can be combined with any of the CH genes (5, 6).Antibody specificity is determined by genetic differences in the V region genes (idiotypes) (6)(7)(8)(9). This idiotypic variation has been studied extensively in mice and rabbits. As early as 1963, antigenic determinants located on V regions of rabbit IgH chains were found (10). Pedigree analysis of rabbits homozygous for two different VH region allotypes demonstrated that VH and CH region allotypes were linked, although recombinants were observed (11).Mendelian studies involving idiotypic determinants of mice have determined that the Ig CH and Ig VH loci are also linked (9, 12-15), although separated by a substantial distance (2). Mouse strains of the same allotype have identical VH gene families; however, in comparisons between inbred strains, each VH gene family is comparable in number but not in the composition of the individual VH genes (16).Utilizing molecular data, it was shown that polytnorphisms in VH coding sequences are directly responsible for two major anti-arsonate idiotypes in A/J mice (17) as well as for different responses to proteins bearing the hapten (4-hydroxy-3-nitrophenyl)acetyl (18). Furthermore, a molecular genetic study of germline variation in six inbred mouse strains demons...

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Genetic regulation of immunoglobulin synthesis

Cited by 103 publications

References 101 publications

Idiotypy of Rabbit Antibodies

Idiotypy of Rabbit Antibodies

DELETION OF b5 IMMUNOGLOBULIN-BEARING LYMPHOCYTES IN ALLOTYPE-SUPPRESSED RABBITS

Polymorphisms of a human variable heavy chain gene show linkage with constant heavy chain genes.

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