Genetic rescue and the increase of litter size in the recovery breeding program of the common hamster (<i>Cricetus cricetus</i>) in the Netherlands. Relatedness, inbreeding and heritability of litter size in a breeding program of an endangered rodent

Haye, M.J.J. La; Koelewijn, H.P.; Siepel, H.; Verwimp, N.; Windig, J.J.

doi:10.1111/j.1601-5223.2012.02277.x

Cited by 14 publications

(19 citation statements)

References 29 publications

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“…Small populations that exist in fragmented landscapes are expected to increase in mean inbreeding levels over time (Wright et al 2007;Frankham et al 2017) and monitoring this process is an important element of genetic management in conservation (Fredrickson et al 2007;La Haye et al 2012). Given the short time-period in which litter size appears to be decreasing at Woolnorth (Farquharson et al 2018), our failure to detect a corresponding change in IR over time may indicate that a measurable increase in population mean inbreeding is yet to occur.…”

Section: Discussionmentioning

confidence: 99%

Inbreeding depression in one of the last DFTD-free wild populations of Tasmanian devils

Gooley

Hogg

Fox³

et al. 2019

Preprint

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Background. Vulnerable species experiencing inbreeding depression are prone to localised extinctions because of their reduced fitness. For Tasmanian devils, the rapid spread of devil facial tumour disease (DFTD) has led to population declines and fragmentation across the species’ range. Here we show that one of the few remaining DFTD-free populations of Tasmanian devils is experiencing inbreeding depression. Moreover, this population has experienced a significant reduction in reproductive success over recent years. Methods. We used 32 microsatellite loci to examine changes in genetic diversity and inbreeding in the wild population at Woolnorth, alongside field data on breeding success from females to test for inbreeding depression. Results. We found that maternal internal relatedness has a negative impact on litter sizes. The results of this study imply that this population has entered an extinction vortex and that to protect the population, genetic rescue may be required. This study provides conservation managers with useful information for managing wild devils and provides support for the “Wild Devil Recovery Program” which is currently augmenting small, isolated populations.

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Section: Discussionmentioning

confidence: 99%

Inbreeding depression in one of the last DFTD-free wild populations of Tasmanian devils

Gooley

Hogg

Fox³

et al. 2019

Preprint

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“…In pedigree dog breeds, outcrossing has been proposed to restore genetic diversity and to overcome a high prevalence of genetic disorders, for example, in the Norwegian Lundehund (Stronen et al., ) and the Griffon Bruxellois (Knowler, Berg, McFadyen, La Ragione, & Rusbridge, ). In wild populations, several examples exist where a single individual restored genetic diversity, for example, in the wolf (Johnson et al., ), in the Florida panther (Vila et al., ) and in the common hamster (La Haye, Koelewijn, Siepel, Verwimp, & Windig, ). Such successful outcrossing is called genetic rescue.…”

Section: Introductionmentioning

confidence: 99%

“…restored genetic diversity, for example, in the wolf (Johnson et al, 2010), in the Florida panther (Vila et al, 2003) and in the common hamster (La Haye, Koelewijn, Siepel, Verwimp, & Windig, 2012). Such successful outcrossing is called genetic rescue.…”

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confidence: 99%

Limits to genetic rescue by outcross in pedigree dogs

Windig

Doekes

2018

J Animal Breeding Genetics

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Outcrossing should reduce inbreeding levels and associated negative effects in highly inbred populations. In this study, we investigated the effectiveness of different outcrossing schemes using computer simulations. The inbreeding rate estimated for a 25-year period of 2.1% per generation in a highly inbred dog breed reduced to 1.8% when a single litter was produced by an outcross without backcrosses. To reduce the inbreeding rate below 1%, more than eight of the 14 litters born yearly in the recipient breed had to be outcrossed. However, outcrossing in pedigree dogs is usually followed by backcrossing and generally involves one or a few litters. Backcrossing reduced the effect of outcrossing considerably. When two litters were produced by an outcross followed by one generation of backcross, the inbreeding rate was 2.0% per generation. Continuously outcrossing was more effective than a single or a few outcrosses. When each newborn litter during 25 years had a 5% chance of being produced by an outcross, the inbreeding rate reduced to -0.2%. To investigate the possibility that new alleles were introduced from the donor population into the recipient population, the fate of different type of alleles (varying from completely lethal to beneficial) before and after an outcross was investigated by first simulating 80 years of natural selection prior to the outcross and then different types of outcross. Because natural selection reduced the frequency of lethal alleles before outcrossing, the introduction of a lethal allele that was segregating in the donor breed but not in the recipient breed occurred rarely. Introduction of slightly detrimental alleles or neutral alleles occurred more frequently. In conclusion, outcrossing only had a limited short-term effect unless repeated continuously. Nevertheless, it may help to buy time in which the population structure can be changed so that the effective population size increases.

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“…The concept of ‘genetic rescue’ is based on the prevention or reversal of this situation, and an increase in gene flow has been shown to lead to higher fitness and demographic growth (La Haye et al . ; Heber et al . ).…”

Section: Introductionmentioning

confidence: 99%

“…Dunn et al 2011;Hedrick et al 2014). The concept of 'genetic rescue' is based on the prevention or reversal of this situation, and an increase in gene flow has been shown to lead to higher fitness and demographic growth (La Haye et al 2012;Heber et al 2013). Most mammals display male-biased dispersal; that is, males disperse farther and more frequently from the natal home range than females.…”

Section: Introductionmentioning

confidence: 99%

Y chromosome haplotype distribution of brown bears (Ursus arctos) in Northern Europe provides insight into population history and recovery

Schregel

Eiken

Grøndahl³

et al. 2015

Molecular Ecology

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High-resolution, male-inherited Y-chromosomal markers are a useful tool for population genetic analyses of wildlife species, but to date have only been applied in this context to relatively few species besides humans. Using nine Y-chromosomal STRs and three Y-chromosomal single nucleotide polymorphism markers (Y-SNPs), we studied whether male gene flow was important for the recent recovery of the brown bear (Ursus arctos) in Northern Europe, where the species declined dramatically in numbers and geographical distribution during the last centuries but is expanding now. We found 36 haplotypes in 443 male extant brown bears from Sweden, Norway, Finland and northwestern Russia. In 14 individuals from southern Norway from 1780 to 1920, we found two Y chromosome haplotypes present in the extant population as well as four Y chromosome haplotypes not present among the modern samples. Our results suggested major differences in genetic connectivity, diversity and structure between the eastern and the western populations in Northern Europe. In the west, our results indicated that the recovered population originated from only four male lineages, displaying pronounced spatial structuring suggestive of large-scale population size increase under limited male gene flow within the western subpopulation. In the east, we found a contrasting pattern, with high haplotype diversity and admixture. This first population genetic analysis of male brown bears shows conclusively that male gene flow was not the main force of population recovery.

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Genetic rescue and the increase of litter size in the recovery breeding program of the common hamster (Cricetus cricetus) in the Netherlands. Relatedness, inbreeding and heritability of litter size in a breeding program of an endangered rodent

Cited by 14 publications

References 29 publications

Inbreeding depression in one of the last DFTD-free wild populations of Tasmanian devils

Inbreeding depression in one of the last DFTD-free wild populations of Tasmanian devils

Limits to genetic rescue by outcross in pedigree dogs

Y chromosome haplotype distribution of brown bears (Ursus arctos) in Northern Europe provides insight into population history and recovery

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