Genetic resistance to fowl cholera is linked to the major histocompatibility complex

Lamont, Susan J.; Bolin, Carole A.; Cheville, N. F.

doi:10.1007/bf00404420

Cited by 85 publications

(38 citation statements)

References 24 publications

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“…The Major Histocompatibility Complex (MHC) is a cluster of genes which encodes cell-surface glycoproteins that are involved in antigen recognition in immune responses. The MHC, or the B-complex as it is called in chickens, is closely associated with individual differences in susceptibility to many poultry diseases, such as Marek's disease (Briles et al, 1982), Rous sarcoma virus (Plachy et al, 1992), fowl cholera caused by Pasteurella multocida (Lamont et al, 1987), coccidiosis (Bumstead and Millard, 1987;Caron et al, 1997) and salmonellosis (Cotter et al, 1998). Although information on the involvement of the B-complex in resistance to helminth infections is very limited, Wetherall and Groth (1992) have shown that in mice certain MHC haplotypes are associated with resistance to helminths.…”

Section: Discussionmentioning

confidence: 99%

Comparative genetic resistance to Ascaridia galli infections of 4 different commercial layer-lines

Schou

Permin

Roepstorff

et al. 2003

British Poultry Science

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1. The objective of the study was to compare the establishment and effect of Ascaridia galli infections in 4 different layer-lines. 2. A total of 160 birds comprising 4 different commercial layer-lines, ISA Brown, New Hampshire, Skalborg and a cross of New Hampshire(NH) and Skalborg (Sk), were infected with A. galli eggs. The birds were examined for the presence of parasite eggs and parasites at weeks 3, 6 and 9 post infection (pi). 3. At week 6 pi the chickens of the NH line harboured more larvae compared with the three other lines. The Sk line chickens excreted more A. galli eggs throughout the study compared with the other lines. Female worms in the Sk line were more fecund than the worms in the other lines. Male and female worms recovered from the Sk line at week 9 pi were longer. Male worms recovered from the NH line 6 weeks pi were shorter than male worms from the other lines. Female worms recovered from the NH line were shorter than the female worms from the ISA line and the Sk line. No differences were seen in weight gain among the 4 lines. 4. The results suggest that genetic factors are involved in the establishment and survival of A. galli in the intestine of layers. Further studies are needed to elucidate the genetic mechanisms behind the observed parasitological findings.

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Section: Discussionmentioning

confidence: 99%

Comparative genetic resistance to Ascaridia galli infections of 4 different commercial layer-lines

Schou

Permin

Roepstorff

et al. 2003

British Poultry Science

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“…Autoimmune disease associations with HLA are sometimes reported for alleles at individual loci, but with few exceptions it is difficult to understand whether individual loci or other genes nearby are actually responsible for the observed effect. In the chicken, MHC-B haplotypes, until recently distinguished primarily by serological methods, display strong influences in several infectious diseases (1)(2)(3)(4)(5). Resistance to Marek's disease tumors was mapped to a gene, or genes, closely linked to serologically-defined MHC-B class I (as opposed to BG Ags) in analyses of rMHC-B haplotypes (6 -8).…”

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confidence: 99%

Extended Gene Map Reveals Tripartite Motif, C-Type Lectin, and Ig Superfamily Type Genes within a Subregion of the Chicken MHC-B Affecting Infectious Disease

Shiina

Briles

Goto

et al. 2007

The Journal of Immunology

116

149

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MHC haplotypes have a remarkable influence on whether tumors form following infection of chickens with oncogenic Marek’s disease herpesvirus. Although resistance to tumor formation has been mapped to a subregion of the chicken MHC-B region, the gene or genes responsible have not been identified. A full gene map of the subregion has been lacking. We have expanded the MHC-B region gene map beyond the 92-kb core previously reported for another haplotype revealing the presence of 46 genes within 242 kb in the Red Jungle Fowl haplotype. Even though MHC-B is structured differently, many of the newly revealed genes are related to loci typical of the MHC in other species. Other MHC-B loci are homologs of genes found within MHC paralogous regions (regions thought to be derived from ancient duplications of a primordial immune defense complex where genes have undergone differential silencing over evolutionary time) on other chromosomes. Still others are similar to genes that define the NK complex in mammals. Many of the newly mapped genes display allelic variability and fall within the MHC-B subregion previously shown to affect the formation of Marek’s disease tumors and hence are candidates for genes conferring resistance.

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“…The chicken major histocompatibility complex (MHC) has been associated with resistance, susceptibility, and differential responses to vaccines (Bacon, 1987;Lamont et al, 1987;Lamont, 1989;Heller et al, 1991;Kaufman, 2008). MHC haplotypes were commonly defined by serological reactions based on BF (MHC class I) and BG (MHC class IV) antigens (Briles and Briles, 1982).…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity analysis of the major histocompatibility complex (MHC) region in Indian native chicken breeds and pureline chickens using the LEI0258 microsatellite marker

Kannaki

Reddy

Chatterjee

2017

IJAR

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The chicken major histocompatibility complex (MHC) plays an important role in immune response and is strongly associated with resistance and susceptibility to many diseases. The microsatellite marker LEI0258 is physically located within MHC, between the BG and BF regions and can identify serologically well-defined MHC haplotypes. In the present study, a total of 150 samples from pureline chicken breeds including Indian native chicken breeds Aseel (20), Kadaknath (45), White Leghorn (IWI-20; IWK-23), Dahlem red (DR-20), Broiler (PB1-22) was investigated by using LEI0258 microsatellite marker. Overall 22 differently sized alleles (182-552 bp) were identified in all the five lines. Our results indicate that Indian native chicken breeds Aseel (Na=10) and Kadaknath (Na=11) harbored more alleles compared to those of pureline populations (Na=5-6). Analysis of Hardy-Weinberg's equilibrium (HWE) revealed that two populations IWI and Kadaknath deviated from the HWE (P<0.001). LEI0258 microsatellite based MHC haplotyping would be useful in selecting birds for breeding programs and also in genetic resource conservation.

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Genetic resistance to fowl cholera is linked to the major histocompatibility complex

Cited by 85 publications

References 24 publications

Comparative genetic resistance to Ascaridia galli infections of 4 different commercial layer-lines

Comparative genetic resistance to Ascaridia galli infections of 4 different commercial layer-lines

Extended Gene Map Reveals Tripartite Motif, C-Type Lectin, and Ig Superfamily Type Genes within a Subregion of the Chicken MHC-B Affecting Infectious Disease

Genetic diversity analysis of the major histocompatibility complex (MHC) region in Indian native chicken breeds and pureline chickens using the LEI0258 microsatellite marker

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