Genetic resistance to infectious laryngotracheitis in inbred lines of White Leghorn chickens

Molecular epidemiology of infectious laryngotracheitis: a review

“…Application of the CEO vaccine via drinking water relies on contact of the vaccine with the nasal cavity during the act of drinking (Robertson & Egerton, 1981;Loudovaris et al, 1991;Devlin et al, 2008). Uneven coverage of a flock allows the vaccine strains to circulate for prolonged periods within the flock.…”

Genetic susceptibility of chicken macrophages toin vitroinfection with infectious laryngotracheitis virus

“…The critical involvement of the macrophages in recovery from ILT may be in the processing and presentation of viral antigens (Mills, 1986). The higher percentages of viral antigen positive cells detected after ILTV infection of macrophages from chickens which are genetically resistant (Loudovaris et al, 1991), suggests that the macrophages from these chickens may be better able to process viral antigen and present it to the immune system. This is consistent with the higher titres of ILTV antibody produced by chickens of the resistant inbred J[ and N, lines, compared to the susceptible inbred M, line (Loudovaris et al, 1991).…”

“…There were significant differences in the percentages of macrophages expressing ILTV antigen between the inbred lines of chickens. A greater proportion of macrophages from the relatively resistant ^ (ß 113 ) and N, (ß 114 ) chickens (Loudovaris et al, 1991) were found with ILTV antigens, than macrophages from the susceptible M! (ß 15 ) chickens.…”

“…inbred lines of chicken have been previously found to be relatively resistant to a clinical challenge with ILTV, whilst the M! inbred line of chicken was relatively susceptible (Loudovaris et al, 1991).…”

“…In a previous study various inbred lines of White Leghorn chickens were found to differ in their susceptibility to infectious laryngotracheitis after intratracheal challenge (Fahey et al, 1984;Loudovaris et al, 1991). This paper describes an in vitro investigation of the comparative susceptibility of macrophages from three of these inbred lines of chicken to infection by ILTV.…”