Genetic Risk Factors of Intracranial Atherosclerosis

Liu, Minghua; Gutierrez, José

doi:10.1007/s11883-020-0831-5

Cited by 20 publications

(11 citation statements)

References 113 publications

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“…Genetic association studies have also been promising in the prediction of inflammation in the context of atherosclerosis. 163 , 164 Advances in genetics have facilitated the possibility of devising genetic biomarkers for estimatng the risk of atherosclerosis . Evaluation of diverse biomarkers, referring to the already recognized familial history of cardiovascular disorders in parents along with hs-CRP, improved the potential of the traditional risk factors in the prediction of the cardiovascular risk.…”

Section: Prospective and Future Directionsmentioning

confidence: 99%

Inflammatory Markers Related to Innate and Adaptive Immunity in Atherosclerosis: Implications for Disease Prediction and Prospective Therapeutics

Hong

Xue

Shao

2021

JIR

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Several lines of evidence have linked a dysregulated inflammatory setting to the pathogenesis of atherosclerosis, which is a form of chronic vascular inflammation. Various inflammatory biomarkers have been associated with inflammation and are recognized as potential tools to monitor the progression of atherosclerosis. A well-studied inflammatory marker in the context of cardiovascular diseases is C-reactive protein (CRP) or, more accurately, highly sensitive-CRP (hs-CRP), which has been established as an inflammatory biomarker for atherosclerotic events. In addition, a growing body of investigations has attempted to disclose the potential of inflammatory cytokines, enzymes, and genetic polymorphisms related to innate and adaptive immunity as biomarkers for predicting the development of atherosclerosis. In this review article, we clarify both traditional and novel inflammatory biomarkers related to components of the innate and adaptive immune system that may mirror the progression or phases of atherosclerotic inflammation/lesions. Furthermore, the contribution of the inflammatory biomarkers in developing potential therapeutics against atherosclerotic treatment will be discussed.

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Section: Prospective and Future Directionsmentioning

confidence: 99%

Inflammatory Markers Related to Innate and Adaptive Immunity in Atherosclerosis: Implications for Disease Prediction and Prospective Therapeutics

Hong

Xue

Shao

2021

JIR

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“…28 The C677TT polymorphism of the MTHFR gene has been related to endothelial dysfunction and vascular oxidative stress caused by high levels of 5-methylenetetrahydrofolate (5-MTHRF). 29,30 MTHFR-linked hyperhomocysteinaemia has previously been regarded as the main cause of endothelial dysfunction and atherogenesis. 31 The MTHFR 677TT variant has a stronger influence on 5-MTHF levels than on Hcy levels.…”

Section: Discussionmentioning

confidence: 99%

Association of the methylenetetrahydrofolate reductase (MTHFR) gene variant C677T with serum homocysteine levels and the severity of ischaemic stroke: a case–control study in the southwest of China

Huang

et al. 2022

J Int Med Res

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Objective To determine whether the methylenetetrahydrofolate reductase ( MTHFR) C677T gene polymorphism is linked to the risk of ischaemic stroke and circulating homocysteine (Hcy) levels in a Chinese population. Methods This case–control study recruited angiogram-diagnosed patients with ischaemic stroke and healthy control subjects. The plasma Hcy concentrations were measured and the MTHFR C677T gene polymorphism was genotyped. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the severity of the ischaemic stroke. Results This study recruited 198 patients with ischaemic stroke and 168 controls. The TT genotype conferred a higher risk for ischaemic stroke than the CC genotype (odds ratio of 3.563; 95% confidence interval [CI] 1.412, 4.350). The T allele was the predisposing allele for ischaemic stroke. Hcy had an area under the receiver operating characteristic (ROC) curve of 0.624 (95% CI 0.530, 0.758). The ROC for Hcy demonstrated its usefulness in predicting ischaemic stroke. Hcy levels were not associated with ischaemic stroke severity as measured by the NIHSS. Conclusion The MTHFR C677T gene polymorphism affects circulating Hcy levels. The MTHFR C677T gene polymorphism and hyperhomocysteinaemia may play important roles in predicting the risk of ischaemic stroke.

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“…ICAS is a complex disease influenced by multiple effects of genetic in combination with lifestyle and environmental factors [4]. Here, we discover a new genetic disorder that is associated with susceptibility to ICAS.…”

Section: Discussionmentioning

confidence: 99%

“…ICAS is a complex disease influenced by multiple effects of genetic in combination with lifestyle and environmental factors [4].…”

Section: F I G U R Ementioning

confidence: 99%

Glucose‐6‐phosphate dehydrogenase deficiency and intracranial atherosclerotic stenosis in stroke patients

Chen

et al. 2022

Euro J of Neurology

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Background and purpose Intracranial atherosclerotic stenosis (ICAS) is a major cause of stroke in Asian countries. Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency, a hereditary enzyme defect prevalent in Asian countries, has been associated with atherosclerotic cardiovascular disease and worse poststroke outcomes. However, the impact of G6PD deficiency on ICAS remains unclear. We aimed to compare the risk of ICAS in stroke patients with and without G6PD deficiency in a Chinese cohort. Methods We prospectively and consecutively recruited stroke patients from four centers in China. All patients received intracranial artery assessment by magnetic resonance/computed tomography angiography or digital subtraction angiography, as well as G6PD enzyme evaluation. The prevalence, burden, and characteristics of ICAS were compared between patients with and without G6PD deficiency using multivariate regression analysis. Results Among 1593 patients, 116 (63.7%) of 182 patients with G6PD deficiency and 714 (50.6%) of 1411 patients with normal G6PD levels were identified as ICAS. Age, hypertension, diabetes, and G6PD deficiency were independent predictors of ICAS. Among patients with ICAS, G6PD‐deficient individuals were more likely to have multiple (≥2 segments) intracranial stenosis (odds ratio [OR] = 1.87, 95% confidence interval [CI] = 1.25–2.81, p = 0.002). G6PD deficiency increased the risk of ICAS in patients who were male (OR = 1.82, 95% CI = 1.24–2.66, p = 0.002), aged ≥70 years (OR = 2.40, 95% CI = 1.33–4.31, p = 0.004), or hypertensive (OR = 1.88, 95% CI = 1.28–2.77, p = 0.001). Conclusions Stroke patients with G6PD deficiency have a higher prevalence and ICAS burden than those with normal G6PD, particularly those who are male, older, and hypertensive.

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Genetic Risk Factors of Intracranial Atherosclerosis

Cited by 20 publications

References 113 publications

Inflammatory Markers Related to Innate and Adaptive Immunity in Atherosclerosis: Implications for Disease Prediction and Prospective Therapeutics

Inflammatory Markers Related to Innate and Adaptive Immunity in Atherosclerosis: Implications for Disease Prediction and Prospective Therapeutics

Association of the methylenetetrahydrofolate reductase (MTHFR) gene variant C677T with serum homocysteine levels and the severity of ischaemic stroke: a case–control study in the southwest of China

Glucose‐6‐phosphate dehydrogenase deficiency and intracranial atherosclerotic stenosis in stroke patients

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