Genetic risk factors of thrombophilia in ischaemic childhood stroke of cardiac origin. A prospective ESPED survey

Sträter, Ronald; Vielhaber, H.; Kassenböhmer, Rainer; Kries, Rüdiger von; Göbel, U.; Nowak‐Göttl, Ulrike

doi:10.1007/pl00014336

Cited by 101 publications

(76 citation statements)

References 5 publications

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“…Results of available studies differ, mainly because of differences in the study populations, age groups, or study designs. [15][16][17][18][19][20][21][22][23][24][25] Very recently, we have shown that an increased Lp(a) level, the FV G1691A mutation, the PT 20210A allele, and the homozygous C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene are significant risk factors for spontaneous stroke in childhood. 23 That study, however, did not include neonatal and child patients with additional acquired risk factors.…”

mentioning

confidence: 99%

Symptomatic Ischemic Stroke in Full-Term Neonates

Günther

Junker²,

Sträter³

et al. 2000

Stroke

277

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mentioning

confidence: 99%

Symptomatic Ischemic Stroke in Full-Term Neonates

Günther

Junker²,

Sträter³

et al. 2000

Stroke

277

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“…In older children with AIS, the data has been conflicting and has been hampered by the small number of cases in some of the published studies (Bonduel et al, 1999;McColl et al, 1999;Nowak-Gottl et al, 1999;Strater et al, 1999;Kenet et al, 2000). Nevertheless, there does seem to be a trend towards an increased incidence of prothrombotic abnormalities in older children with AIS Chan et al, 2000).…”

Section: Fetal and Neonatal Thrombophiliamentioning

confidence: 99%

Perinatal stroke – risk factors and management

Chalmers

2005

Br J Haematol

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SummaryStroke is an uncommon but increasingly recognised cause of mortality and long-term neurological morbidity in children. A significant number of these events appear to be caused by thromboembolic disease and, as with other childhood thrombotic problems, the incidence of central nervous system events appears highest during the neonatal period. In contrast to peripheral arterial and venous thrombotic problems, it is likely that a proportion of cerebral thromboembolic events occur either in utero or perinatally and reflect different risk factors from those occurring in older infants and children. The pathophysiology of perinatal stroke is complex and in many cases is likely to be multifactorial. It is now recognised that risk factors may relate to both maternal and placental problems as well as fetal and neonatal disorders. Large prospective studies of perinatal stroke are currently lacking and efforts to define the relative contribution from each of these areas are at an early stage. The complex nature of these disorders requires collaboration between a number of different disciplines including obstetrics, fetal medicine, pathology, neonatology and neurology. Of particular interest to haematologists is the possible impact of prothrombotic abnormalities in the pathophysiology of these events and also the potential for the use of antithrombotic agents in both management and prevention.

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“…in gestational weeks 10,20,30) to evaluate fetal growth development and to detect possible intrauterine fetal thrombus formation (caval/renal veins, cerebral arteries/veins) prior to delivery postnatal patterns of maturation. In the newborn, plasma concentrations of the vitamin K-dependent coagulation factors (II, VII, IX, X), contact factors (XI, XII, prekallikreine and high-molecular weight kininogen) are approximately 50% of adult values.…”

Section: Practice Pointsmentioning

confidence: 99%

Maternal thrombophilia and neonatal thrombosis

Heller

Nowak‐Göttl

2003

Best Practice & Research Clinical Haematology

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In neonates and infants, numerous clinical and environmental conditions lead to elevated thrombin generation and subsequent thrombus formation. Genetic prothrombotic defects (protein C, protein S and antithrombin deficiency, mutations of coagulation factor V and factor II, elevated lipoprotein (a)) have been established as risk factors of thromboembolic events in neonates and infants. The interpretation of the laboratory evaluation relies on age-dependent normal reference values. Because appropriate clinical trials are missing in these age groups, treatment recommendations are adapted from small-scale studies in neonates and infants and from guidelines relating to adult patient protocols. Secondary long-term anticoagulation should be administered on an individual basis.

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Genetic risk factors of thrombophilia in ischaemic childhood stroke of cardiac origin. A prospective ESPED survey

Cited by 101 publications

References 5 publications

Symptomatic Ischemic Stroke in Full-Term Neonates

Symptomatic Ischemic Stroke in Full-Term Neonates

Perinatal stroke – risk factors and management

Maternal thrombophilia and neonatal thrombosis

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