Genetic Selection for Insulin-Like Growth Factor-1 in Growing Mice Is Associated With Altered Growth

Blair, Hugh T.; McCutcheon, S. N.; Mackenzie, D. D. S.; Ormsby, J. E.; Siddiqui, Rafat A.; Breier, Bernhard H.; Gluckman, Peter D.

doi:10.1210/endo-123-3-1690

Cited by 37 publications

(20 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This balanced relationship would explain the positive correlationship between circulating immunoreactive IGF-I levels and growth rate values throughout the experimental period, since the former could be mainly derived from the liver in response to GH action. A similar relationship has been reported in mammals and avian species not only on a temporal basis (Merimee et al 1981;Eigenmann et al 1984), but also when comparisons are made between growth selected lines (Blair et al 1988;Scanes et al 1989). …”

Section: Discussionsupporting

confidence: 72%

Seasonal changes in circulating growth hormone (GH), hepatic GH-binding and plasma insulin-like growth factor-I immunoreactivity in a marine fish, gilthead sea bream,Sparus aurata

Pérez‐Sánchez

1994

Fish Physiol Biochem

112

View full text Add to dashboard Cite

We have studied the seasonal relationship between growth and circulating growth hormone (GH), hepatic GH-binding and plasma insulin-like growth factor-I immunoreactivity in gilthead sea bream,Sparus aurata. The seasonal increase in plasma GH levels preceded by several weeks the summer increase in growth rates. In contrast, a marked increase in hepatic GH-binding with a high degree of endogenous GH occupancy was found during the period of maximum growth which suggests an enhanced sensitivity of liver to GH action. Thus, circulating levels of immunoreactive IGF-I, probably derived from the liver in response to GH action, were positively correlated with growth throughout the experimental period although a consistent relationship between growth and circulating GH was not found. In spite of this, we consider that, in gilthead sea bream, as in several other teleosts, the availability of endogenous GH can limit growth. Thus, under environmental conditions of suboptimal growth, a single intraperitoneal injection of recombinant rainbow trout GH (rtGH) induced over the dose range tested (0.75, 1.5, 3 μg g BW(-1)) an increase in plasma IGF-I-like immunoreactivity comparable to that seen during the period of maximum growth.

show abstract

Section: Discussionsupporting

confidence: 72%

Seasonal changes in circulating growth hormone (GH), hepatic GH-binding and plasma insulin-like growth factor-I immunoreactivity in a marine fish, gilthead sea bream,Sparus aurata

Pérez‐Sánchez

1994

Fish Physiol Biochem

112

View full text Add to dashboard Cite

show abstract

“…Moreover, plasma IGF-I levels in humans correlate with body size. Constitutional tall children have elevated plasma IGF-I levels (172), whereas lines of mice selected for high IGF-I levels show increased body weight (173). Infusions of rhIGF-I also enhance body weight and size in a number of models, further suggesting a role for circulating IGF-I in growth.…”

Section: Physiological Effects Of Igfsmentioning

confidence: 99%

The Somatomedin Hypothesis: 2001

et al. 2001

View full text Add to dashboard Cite

Since the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify the concept. Originally somatic growth was thought to be controlled by pituitary GH and mediated by circulating insulin-like growth factor-I (IGF-I, somatomedin C) expressed exclusively by the liver. With the discovery that IGF-I is produced by most, if not all, tissues, the role of autocrine/paracrine IGF-I vs. the circulating form has been hotly debated. Recent experiments using transgenic and gene-deletion technologies have attempted to answer these questions. In the liverspecific igf-1 gene-deleted mouse model, postnatal growth and development are normal despite the marked reduction in circulating IGF-I and IGF-binding protein levels; free IGF-I levels are normal. Thus, the normal postnatal growth and development in these animals may be due to normal free IGF-I levels (from as yet unidentified sources), although the role of autocrine/paracrine IGF-I has yet to be determined.

show abstract

“…Serum levels of insulin-like growth factor 1 (IGF-1) are known to correlate strongly with the rate of lean body growth in mammals (Blair et aL, 1988;Kerr et aL, 1991), and are very sensitive to nutritional status (Teale and Marks, 1986;Breier et aL, 1988). Blood (serum) was collected from wild muskoxen following death.…”

Section: Rangifer 12 (3): 179-183mentioning

confidence: 99%

Seasonal changes in weight, condition and nutrition of free-ranging and captive muskox females

Adamczewski¹,

Gunn²,

Laarveld³

et al. 1992

Ran

View full text Add to dashboard Cite

Genetic Selection for Insulin-Like Growth Factor-1 in Growing Mice Is Associated With Altered Growth

Cited by 37 publications

References 10 publications

Seasonal changes in circulating growth hormone (GH), hepatic GH-binding and plasma insulin-like growth factor-I immunoreactivity in a marine fish, gilthead sea bream,Sparus aurata

Seasonal changes in circulating growth hormone (GH), hepatic GH-binding and plasma insulin-like growth factor-I immunoreactivity in a marine fish, gilthead sea bream,Sparus aurata

The Somatomedin Hypothesis: 2001

Seasonal changes in weight, condition and nutrition of free-ranging and captive muskox females

Contact Info

Product

Resources

About