Genetic sperm defects

Chenoweth, Peter J.

doi:10.1016/j.theriogenology.2005.05.005

Cited by 166 publications

(149 citation statements)

References 28 publications

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“…Even if heads seem to have a normal shape, they can have a disturbed chromatin structure in the nucleus or acrosome defects (Karabinus et al 1997). It has been found that semen containing spermatozoa with head defects may reduce the quality of embryos (De Jarnette et al 1992) and results in miscarriages in the first months of pregnancy (Chenoweth 2005). Larger sperm heads determined in the semen of stallions with decreased fertility may indicate disturbed spermatogenesis, and, first and foremost, changes in the chromatin structure taking place during sperm maturation and transportation in the duct of epididymis (Casey et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Effect of sperm concentration in an ejaculate on morphometric traits of spermatozoa in Duroc boars

Kondracki¹,

Wysokińska²,

Iwanina³

et al. 2011

Polish Journal of Veterinary Sciences

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The experimental material consisted of 75 ejaculates collected form 8 Duroc boars. The ejaculates were divided into three groups according to sperm concentration in an ejaculate. An ejaculate was obtained from each boar monthly and it was used to make microscopic preparations to examine spermatozoa morphology. In each preparation morphometric measurements were taken of fifteen randomly selected spermatozoa characterized by normal morphology. The following measurements of spermatozoa were taken: length and width of the spermatozoa head, head area, length of the flagellum, perimeter of the spermatozoon head and total spermatozoon length. The results were used to calculate indicators of spermatozoa morphology. Moreover, assessments were made of frequency of morphological defects to isolate spermatozoa with primary and secondary abnormalities following the Blom classification system. It was found that the concentration of spermatozoa in the ejaculate influenced the morphometric characteristics of spermatozoa. Ejaculates with low sperm concentrations are characterized by larger spermatozoa as compared to ejaculates with high sperm concentrations. However, sperm concentration in the ejaculate does not much influence the shape of spermatozoa.

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Section: Discussionmentioning

confidence: 99%

Effect of sperm concentration in an ejaculate on morphometric traits of spermatozoa in Duroc boars

Kondracki¹,

Wysokińska²,

Iwanina³

et al. 2011

Polish Journal of Veterinary Sciences

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“…Some of the genetic sperm defects (Chenoweth, 2005) such as Dag and stump tail defects are prevalent in Frieswal bulls; however, their overall mean (6s.e.) frequencies per ejaculate were less.…”

Section: Discussionmentioning

confidence: 99%

Effect of age on spermiogram of Holstein Friesian × Sahiwal crossbred bulls

Mandal

Kumar

Tyagi

2010

Animal

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This study was conducted on 94 Frieswal (5/8 Holstein Friesian 3/8 Sahiwal) crossbred bulls of three different grades, categorized based on their semen freezability visualising Group 1 (consistently freezable semen producer bulls, N 5 11), Group 2 (inconsistent freezable, N 5 16) and Group 3 (Non freezable, N 5 67). Each group was further divided into two classes that is young (up to 30 months) and adult (31 to 70 months) bulls depending upon their age. Sperm morphology was studied by using the eosin-nigrosin staining technique. Bulls age significantly (P , 0.01) affected semen quality and sperm morphology. In adult bulls, semen volume, mass activity and sperm concentration were 36%, 17.56% and 19.6%, respectively, higher than young. Initial progressive motility (%) and livability showed significant (P , 0.01) improvement with the advancement of age (43.37 6 1.21 and 67.71 6 1.11, respectively, in young; 53.02 6 1.11 and 74.17 6 1.03, respectively, in adult). In young bulls, sperm head, mid piece, tail abnormality and total abnormal sperm percent (12.38 6 0.92, 4.87 6 0.24, 11.01 6 0.60 and 28.26 6 1.34, respectively) were 1.85, 1.27, 1.20 and 1.44 folds higher than that of their mature stage (6.69 6 0.64, 3.82 6 0.32, 9.14 6 0.64 and 19.66 6 1.31, respectively). Significant reduction (P , 0.01) in micro cephalic sperm, free heads, bent mid piece, looped mid piece and proximal protoplasmic droplets were observed at mature age as compared with their younger stage. In bulls of consistent freezing category, abnormal sperm heads significantly decreased from 4.40 6 0.31% to 3.28 6 0.02% on maturity. Similarly, in inconsistent freezing grade bulls sperm head abnormality (9.28 6 0.75% to 5.13 6 1.20%) and total abnormal sperm percent (24.89 6 1.43 to 18.73 6 3.40) was decreased over the age. On the contrary, in non-freezing category bulls' sperm morphology did not show significant (P . 0.05) improvement with age advancement, rather some abnormalities like long slender head, under developed/deformed head, abaxial implantation of mid piece, double mid piece, stump tail and distal protoplasmic droplets tend to increased significantly (P , 0.05) with age of bulls. Results indicated that in potential Frieswal bulls semen quality and sperm morphology were improved from young to mature stage, where as, in poor quality (non-freezing) semen producer bulls neither the morphology nor the semen quality showed any improvement with maturity. It was recommended that crossbred bulls producing more than 25% morphologically abnormal sperms in young age (below 30 months) along with poor progressive motility (,50%) and low sperm concentration (,1000 million/ml) need immediate culling with out any expectation of further improvement in semen quality with age advancement.Keywords: Sperm abnormality, Frieswal crossbred bull, Sperm morphology, Bos indicus 3 Bos taurus Implication Assessment of sperm morphology is one of the most important aspects for semen evaluation and successful fertilisation. High percentage of morphologically abnormal spe...

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“…The causes of male infertility are numerous and include endocrinopathies, developmental and anatomical abnormalities, diminished spermatogenesis, and abnormal sperm functional ability. The diverse pathologies associated with male infertility are linked in the fact that many are directly the result of abnormalities in, or damage to, the myriad of genes and=or associated proteins involved in the proper development and functioning of the male reproductive system and its product sperm [4,8,15,17,24].…”

Section: Introductionmentioning

confidence: 99%