Genetic Survey of an Isolated Community in Bali, Indonesia

Breguet, Georges; Ney, R.; Kirk, R. L.; Nm, Blake

doi:10.1159/000153317

Cited by 11 publications

(3 citation statements)

References 9 publications

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“…A very rare example of mutant distribution is illustrated by GclA12 and GclC1', because they are found in Indonesia (Bali) and India (Papiha, personal communication). Their presence in these two groups is in agreement with the tales and mythologies of the Balinese group, which indicate an Indian origin (Breguet et al, 1982b). That these mutants are also present in Europe constitutes an interesting genetic evidence of the Indo-European migrations.…”

Section: Anthropological Relationship Between Asian Groups and Amerinsupporting

confidence: 86%

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Population distribution of the human vitamin D binding protein: Anthropological considerations

Constans¹,

Hazout

Garruto

et al. 1985

American J Phys Anthropol

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The polymorphism of the serum vitamin D binding protein (DBP) in humans is based on the existence of three common alleles, Gc1F, Gc1S, and Gc2, and 84 rare alleles. The geographical distribution of Gc1F, Gc1S, and Gc2 alleles shows north to south clines, together with a balanced equilibrium between the Gc1F or Gc1S allele frequency and the Gc2 frequency. The distribution of the FST values shows high variability within a geographical area. For European and North Asiatic groups, the FST values are the lowest observed, and the reason may be a long process of homogenization. Aboriginal populations from Australia and New Guinea and groups from both North Africa and South America show the greatest heterogeneity of their allele frequencies. Systematic factors such as genetic drift and selection may account for this distribution. In contrast with the three main DBP alleles, the distribution of the rare alleles corresponds to patterns of human migrations that occurred during prehistoric and historic periods. Thus, the rare mutants are of particular relevance to anthropological and genetical investigations.

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Section: Anthropological Relationship Between Asian Groups and Amerinsupporting

confidence: 86%

“…haplotype was detected in the community of Tenganam (Bali) (Breguet et al, 1982b). Ac-In the Gm system, the Gm1,17,23,5,10,11,13,14 cording to Schanfeld et al (1980), the Gml;17,-5,10,11,13,14 when associated with the Gm23 antigen is characteristic of the African populations.…”

Section: A Common Ancestor For African Andmentioning

confidence: 75%

Population distribution of the human vitamin D binding protein: Anthropological considerations

Constans¹,

Hazout

Garruto

et al. 1985

American J Phys Anthropol

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“…There may be regional differences in the incidence of G6PD defi ciency. Brequet et al [24] also observed a high frequency of G d-(10.8%) in isolated popula tions of Bali compared to that in the east Bali nese (2%). The high incidence of G6PD defi ciency may be due to malarial endemicity in some rural areas of Indonesia.…”

Section: G6pd Variantsmentioning

confidence: 86%

Molecular Variants of Red Cell Glucose-6-Phosphate Dehydrogenase Deficiency in Central Java, Indonesia

Soemantri

Saha

et al. 1995

Hum Hered

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One hundred and sixty-nine Javanese males were screened for the presence of red cell glucose-6-phosphate dehydrogenase (G6PD) variants by a dye decoloration screening test and starch gel electrophoresis. The frequency of G6PD deficiency was 14%. Three non-deficient electrophoretic variants with mobilities of 95, 105 and 107% of Gd^B+ were encountered. Sixteen G6PD-defïcient subjects were further investigated for the presence of mutations at nt95 A→G, nt487 G→A, nt493 A→G, nt563 C→T, nt1024 C→T, nt1376 G→T, nt1388 G→A and the silent mutation (nt1311 C→T) of the G6PD gene by natural or artificially created amplified restriction sites. They were identified by the polymerase chain reaction and electrophoresis of restriction-digested products. Five subjects had the Mediterranean mutation (nt563 C→T), but only one had simultaneous presence of nt1311(T). The next common mutations were 1376(T) in three subjects and 487(A) in two subjects. Five of the sixteen subjects had the nt 1311(T) mutation giving an overall frequency of 0.31. The other four mutations were absent in this population sample.

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Khmers of Cambodia: A comparative genetic study of the populations of Southeast Asia

Mastana

Singh

et al. 1994

American J Hum Biol

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A sample of the Khmer population from Cambodia has been examined for 30 single-gene characters (10 blood groups and 20 serum and red cell systems). A locus-by-locus comparison suggests that the Khmers differ significantly in several systems from the populations of Eastern India and China. There is remarkable heterogeneity among their geographical neighbors. To elucidate the genetic relationship of the Khmer, genetic data were collected from various published and unpublished sources, and different multivariate analyses were performed. The analyses show that the Khmers definitely show closer affinity for the neighboring populations of Thailand and Malaysia. The Chinese population not only shows a close relationship to the Khmers, but also consistently stays close to the populations of the Southeast Asian peninsula. The present-day Khmers are genetically distant from the population of Eastern India, but the analyses do not totally exclude gene flow from Eastern India. It is, therefore, concluded that the original gene pool of Khmers may have derived from China, being modified by mixing with the local and Indian migrant populations. © 1994 Wiley-Liss, Inc.

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Genetic Survey of an Isolated Community in Bali, Indonesia

Cited by 11 publications

References 9 publications

Population distribution of the human vitamin D binding protein: Anthropological considerations

Population distribution of the human vitamin D binding protein: Anthropological considerations

Molecular Variants of Red Cell Glucose-6-Phosphate Dehydrogenase Deficiency in Central Java, Indonesia

Khmers of Cambodia: A comparative genetic study of the populations of Southeast Asia

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