Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma

Cloos, Jacqueline; Spitz, Margaret R.; Schantz, Stimson P.; Hsu, T. C.; Zhang, Zuo‐Feng; Tobi, Hilde; Braakhuis, Boudewijn J.M.; Snow, Gordon B.

doi:10.1093/jnci/88.8.530

Cited by 158 publications

(97 citation statements)

References 30 publications

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“…However, G 2 response to X-rays cannot simply be regarded as a surrogate for response to bleomycin because, although breast cancer cases show enhanced X-ray sensitivity, they exhibit a normal bleomycin response (Hsu et al, 1989). Also, unlike our present observations on head and neck cancer patients, Cloos et al (1996) found a significant positive correlation between age and G 2 bleomycin sensitivity in 313 such patients.…”

Section: The G 2 Assaycontrasting

confidence: 90%

“…Enhanced sensitivity of G 2 lymphocytes of head and neck cancer patients to the chromosome-damaging agent, bleomycin, has been reported in several studies (references in Cloos et al, 1996). In a large case-control study of risk-factors for head and neck cancer, in which age, history of tobacco and alcohol usage, and bleomycin G 2 sensitivity were recorded, it was shown that the latter parameter is a biomarker of cancer susceptibility, since it modulates the risk from carcinogen exposure (Cloos et al, 1996).…”

Section: The G 2 Assaymentioning

confidence: 89%

“…In a large case-control study of risk-factors for head and neck cancer, in which age, history of tobacco and alcohol usage, and bleomycin G 2 sensitivity were recorded, it was shown that the latter parameter is a biomarker of cancer susceptibility, since it modulates the risk from carcinogen exposure (Cloos et al, 1996). It has also been shown that, as in the case of G 2 X-ray sensitivity , there is a strong inherited component in G 2 bleomycin sensitivity (Cloos et al, 1999).…”

Section: The G 2 Assaymentioning

confidence: 99%

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Sensitivity to radiation-induced chromosome damage may be a marker of genetic predisposition in young head and neck cancer patients

et al. 2001

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SummaryWe previously showed that levels of chromosome damage induced by ionizing radiation were, on average, higher in G 2 and G 0 lymphocytes of breast cancer patients than of normal healthy controls, but that there was no correlation between the results in the two assays. We proposed that enhanced sensitivity to G 2 or G 0 irradiation was a marker of low-penetrance predisposition to breast cancer, and have recently demonstrated heritability of sensitivity in families of breast cancer cases. We have now applied these assays to patients with head and neck cancers, for whom there is epidemiological evidence of inherited predisposition in addition to environmental causes. The mean frequency of radiation-induced G 2 aberrations was higher in the 42 patients than in 27 normal controls, but not significantly so. However, cases less than 45 years old were significantly more sensitive than normals of the same age range (P = 0.046), whereas there was no difference between patients and normals of less than 45 years. Also, there was an inverse correlation between G 2 sensitivity and age for patients but not for normals. Radiation-induced micronuclei in G 0 cells were more frequent in 49 patients than in 31 normals (P = 0.056) but, as with the G 2 assay, the greatest difference was seen between early-onset patients and young normals. Again there was an inverse correlation with age for patients but not for normals. Six patients with enhanced toxicity to radiotherapy were G 2 tested and four other such patients were G 0 tested; levels of chromosome damage were not significantly greater than in patients with normal reactions. Both assays were used on 64 individuals (39 patients, 25 normals) and there was no significant correlation between the results. We suggest that a proportion of early-onset head and neck cancer patients are genetically predisposed and that each of the two assays detects a different subset of these cases.

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Section: The G 2 Assaycontrasting

confidence: 90%

Section: The G 2 Assaymentioning

confidence: 89%

Section: The G 2 Assaymentioning

confidence: 99%

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Sensitivity to radiation-induced chromosome damage may be a marker of genetic predisposition in young head and neck cancer patients

et al. 2001

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“…However, it has been speculated that exposure of the epithelium to carcinogens at a young age may reduce the period of latency in carcinogenesis. 21 Genetic susceptibility 22,23 may play a role in oral carcinogenesis together with exposure to external agents. In some patients, susceptibility to develop oral cancer may be explained by an impaired ability to repair damaged DNA.…”

Section: Discussionmentioning

confidence: 99%

Incidence and survival of squamous cell carcinoma of the tongue in Scandinavia, with special reference to young adults

Annertz

Anderson

Biörklund

et al. 2002

Intl Journal of Cancer

222

129

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In several countries, increased incidence of squamous cell carcinoma (SCC) of the tongue in young adults has been suspected during the last decades. Some reports indicate a lower survival rate for young patients compared to older patients. In other reports, there has not been any considerable difference in survival when comparing young adults to older patients, whereas some authors have shown better survival for young adults. This disease is rare in young adults, and early reports were based on comparable small numbers and selected patients. Our aim was first to perform a population-based study to determine if an increased incidence in SCC of the tongue could be verified in a larger population comprising the Scandinavian countries Denmark, Finland, Sweden and Norway. A second aim was to determine survival rates for young adults compared to older patients. The material was based on the annual cancer incidence and survival reports from the Scandinavian cancer registries. The study period was 1960 -1994. During that period, 5,024 SCCs of the tongue were reported. Of these, 276 (5.5%) were young adults (20 -39 years). The incidence increased at all ages except for women 65-79 years old. The increase was most pronounced in young adults: 0.06 -0.32 for men and 0.03-0.19 for women, counted by 100,000 person-years. Relative survival was significantly better for young adults compared to older patients.

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“…Mutagen sensitivity is not influenced by gender, tumor stage, or smoking and alcohol intake of the subjects and only slightly increases with age (4,10,11); it is considered to be an intrinsic factor, reflecting how an individual copes with DNA damage (12). In combination with carcinogenic exposure (smoking and alcohol intake), a mutagen hypersensitivity phenotype is associated with a greatly increased risk of developing HNSCC (13). Moreover, it was shown in a prospective patient study that mutagen hypersensitivity is related to the development of second primary tumors (5).…”

Section: Introductionmentioning

confidence: 99%

Microarray Analysis of Bleomycin-Exposed Lymphoblastoid Cells for Identifying Cancer Susceptibility Genes

Cloos

Boer²,

Snel³

et al. 2006

Molecular Cancer Research

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The uncovering of genes involved in susceptibility to the sporadic cancer types is a great challenge. It is well established that the way in which an individual deals with DNA damage is related to the chance to develop cancer. Mutagen sensitivity is a phenotype that reflects an individual's susceptibility to the major sporadic cancer types, including colon, lung, and head and neck cancer. A standard test for mutagen sensitivity is measuring the number of chromatid breaks in lymphocytes after exposure to bleomycin. The aim of the present study was to search for the pathways involved in mutagen sensitivity. Lymphoblastoid cell lines of seven individuals with low mutagen sensitivity were compared with seven individuals with a high score. RNA was isolated from cells exposed to bleomycin (4 hours) and from unexposed cells.

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Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma

Abstract: More accurate risk estimation can define susceptible subgroups who might be targeted for intensive behavioral interventions, surveillance through screening, and enrollment in chemoprevention programs.

Cited by 158 publications

References 30 publications

Sensitivity to radiation-induced chromosome damage may be a marker of genetic predisposition in young head and neck cancer patients

Sensitivity to radiation-induced chromosome damage may be a marker of genetic predisposition in young head and neck cancer patients

Incidence and survival of squamous cell carcinoma of the tongue in Scandinavia, with special reference to young adults

Microarray Analysis of Bleomycin-Exposed Lymphoblastoid Cells for Identifying Cancer Susceptibility Genes

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