Genetic susceptibility to high myopia in Han Chinese population

Abstract

High myopia is a common ocular genetic disease in the world. The study sought to investigate the effect of the Insulin-like growth factor-1 (IGF-1) and Matrix metalloproteinase-9 (MMP-9) genes polymorphisms on high myopia in a Han population of China. This study recruited 216 unrelated Han Chinese subjects, including 103 cases with high myopia and 113 controls. Four tagging single nucleotide polymorphisms (SNPs) of IGF-1 and MMP-9 genes were genotyped using the Sequenom MassARRAY method. The chi-square test showed that the family history was significantly correlated with myopia. The SNP genotypes were all in Hardy–Weinberg equilibrium (P > 0.05). Among the four SNPs, there were statistically significant differences in the genotype and allele frequencies of rs2236416 between the groups (P = 0.024). The significant associations of rs2236416 between cases and controls also appeared after Bonferroni multiple correction (P = 0.024). Then, there were significant differences in the genotypes dominant model and codominant model of rs2236416 between groups (P = 0.007 and P = 0.004, respectively). rs5742632 showed a significant difference between the cases and the controls in the recessive model (P = 0.037). Our findings indicated that rs2236416 of MMP-9 was associated with myopia in the population. The result suggested MMP-9 gene locus may play a role in myopia.

The orientation of choroidal macrophage polarization significantly influences the development of myopia in murine models

“…In addition to its anti-inflammatory properties, LF can reverse high levels of MMP-2 activity in the LIM model, thereby inhibiting myopia (63). Additionally, research has indicated that the MMP-9 gene locus may contribute to myopia (76). Combined with our results, the role of macrophages in oxidative stress response may be a key factor affecting the development of myopia.…”

Effect of different types of Tai Chi exercise programs on the rate of change in bone mineral density in middle-aged adults at risk of osteoporosis: a randomized controlled trial

“…Furthermore, previous research has suggested that specific movements in 24TCC, such as brush knee twist step and wave hands like clouds, generate intensity and impact that can promote the release of growth factors and hormones associated with bone remodeling. These signaling molecules, including IGF-1 [ 41 ] and TGF-β [ 42 ], have been shown to have positive effects on bone health and promote osteoblast function and bone formation.…”

Crosstalk between heredity and environment in myopia: An overview

“…ZFHX1B rs13382811 [ 34 , 43 ], PTPN5 rs1550870 and RASGRF1 rs6495367 [ 44 ], TGF receptor one rs10760673, and TGF receptor 2-AS1 rs7550232 [ 45 ] are also bound up with myopia in children. MMP-9 rs2236416 is interrelated to myopia in the population, suggesting that the MMP-9 gene locus may play a role in myopia [ 46 ]. Moreover, 4q25 rs10034228, 15q14 variation rs524952, and MIPEP variation rs9318086 were significantly concerned in myopia and different myopia severity in southern Chinese people, which together increased the susceptibility risk of high myopia by ten times [ 47 ] ( Table 1 ).…”

“… 2017 [ 43 ] PTPN5 rs1550870, RASGRF1 rs6495367 Xiao, H. 2021 [ 44 ] TGF receptor one rs10760673, TGF receptor 2-AS1 rs7550232 Liu, L. 2021 [ 45 ] MMP-9 rs2236416 Li, Y. 2022 [ 46 ] 4q25 rs10034228, 15q14 rs524952, MIPEP rs9318086 Liu, J. 2021 [ 47 ] …”