Genetic technologies for disease vectors

Criscione, Frank; O’Brochta, David A.; Reid, William

doi:10.1016/j.cois.2015.04.012

Cited by 10 publications

(11 citation statements)

References 81 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They permit more specific and efficient genetic modifications. Development of these strategies could provide IPM practitioners with new methods of pest control [ 210 , 211 , 212 ]. ZFNs consist of double DNA-binding modules derived from natural transcription factors bound to the endonucleolytic domains of a Type IIS restriction enzyme, Fok I. TALENs utilize double DNA-binding modules from bacteria TALEs binding to the same Fok I cleavage domain [ 210 ].…”

Section: Integrated Approaches Suitable For Urban Pest Managementmentioning

confidence: 99%

“…Development of RNAi insecticides could prove cost effective and environmentally benign due to its high specificity. RNAi has been experimentally deployed to target several urban and disease-vectoring insect pests including ants, bed bugs, cockroaches, head lice, mosquitoes, red flour beetles, sandflies, termites and tsetse flies [ 195 , 212 , 220 , 221 , 222 , 223 , 224 , 225 ]. In termites, sixteen genes were successfully silenced from host insects or their symbiotic protozoa, revealing potential targets for termite control [ 225 ].…”

Section: Integrated Approaches Suitable For Urban Pest Managementmentioning

confidence: 99%

See 1 more Smart Citation

Insecticide Resistance and Management Strategies in Urban Ecosystems

Zhu

O'Neal

Lavine

et al. 2016

Insects

165

104

View full text Add to dashboard Cite

The increased urbanization of a growing global population makes imperative the development of sustainable integrated pest management (IPM) strategies for urban pest control. This emphasizes pests that are closely associated with the health and wellbeing of humans and domesticated animals. Concurrently there are regulatory requirements enforced to minimize inadvertent exposures to insecticides in the urban environment. Development of insecticide resistance management (IRM) strategies in urban ecosystems involves understanding the status and mechanisms of insecticide resistance and reducing insecticide selection pressure by combining multiple chemical and non-chemical approaches. In this review, we will focus on the commonly used insecticides and molecular and physiological mechanisms underlying insecticide resistance in six major urban insect pests: house fly, German cockroach, mosquitoes, red flour beetle, bed bugs and head louse. We will also discuss several strategies that may prove promising for future urban IPM programs.

show abstract

Section: Integrated Approaches Suitable For Urban Pest Managementmentioning

confidence: 99%

Section: Integrated Approaches Suitable For Urban Pest Managementmentioning

confidence: 99%

Insecticide Resistance and Management Strategies in Urban Ecosystems

Zhu

O'Neal

Lavine

et al. 2016

Insects

165

104

View full text Add to dashboard Cite

show abstract

“…Successful application of CRISPR-Cas9 to edit the germline of arthropods relies on injection of gene-editing materials into pre-blastoderm embryos (embryonic microinjection) 3 – 6 . This dependence is a significant barrier to the successful general application of transformation technologies, particularly for non-specialist laboratories, as it requires expensive equipment and training to implement 4 . In addition, many non-model species are recalcitrant to the technique because their eggs are damaged during the injection procedure, because they cannot be induced to lay large amounts of synchronous eggs, or because they give live birth rather than lay eggs (as in the case of viviparous species such as tsetse flies and aphids).…”

Section: Introductionmentioning

confidence: 99%

Targeted delivery of CRISPR-Cas9 ribonucleoprotein into arthropod ovaries for heritable germline gene editing

et al. 2018

View full text Add to dashboard Cite

Cas9-mediated gene editing is a powerful tool for addressing research questions in arthropods. Current approaches rely upon delivering Cas9 ribonucleoprotein (RNP) complex by embryonic microinjection, which is challenging, is limited to a small number of species, and is inefficient even in optimized taxa. Here we develop a technology termed Receptor-Mediated Ovary Transduction of Cargo (ReMOT Control) to deliver Cas9 RNP to the arthropod germline by injection into adult female mosquitoes. We identify a peptide (P2C) that mediates transduction of Cas9 RNP from the female hemolymph to the developing mosquito oocytes, resulting in heritable gene editing of the offspring with efficiency as high as 0.3 mutants per injected mosquito. We demonstrate that P2C functions in six mosquito species. Identification of taxa-specific ovary-specific ligand–receptor pairs may further extend the use of ReMOT Control for gene editing in novel species.

show abstract

“…With the advent of functional genomics, we are now starting to describe the molecular correlates that form the basis of the olfactory system regulation in mosquitoes. For past reviews on this topic see Criscione et al (2015), Rinker et al (2016) and Adelman et al (2016). Here, we provide a current overview of what is known about the neural and molecular correlates underlying the demonstrated changes in the behavioural repertoire in female mosquitoes.…”

Section: Sensory and Molecular Correlates Of Olfactory Behaviourmentioning

confidence: 99%

Modulation of odour-guided behaviour in mosquitoes

Hill

2021

Cell Tissue Res

View full text Add to dashboard Cite

Mosquitoes are emerging as model systems with which to study innate behaviours through neuroethology and functional genomics. Decades of work on these disease vectors have provided a solid behavioural framework describing the distinct repertoire of predominantly odour-mediated behaviours of female mosquitoes, and their dependence on life stage (intrinsic factors) and environmental cues (extrinsic factors). The purpose of this review is to provide an overview of how intrinsic factors, including adult maturation, age, nutritional status, and infection, affect the attraction to plants and feeding on plant fluids, host seeking, blood feeding, supplemental feeding behaviours, pre-oviposition behaviour, and oviposition in female mosquitoes. With the technological advancements in the recent two decades, we have gained a better understanding of which volatile organic compounds are used by mosquitoes to recognise and discriminate among various fitness-enhancing resources, and characterised their neural and molecular correlates. In this review, we present the state of the art of the peripheral olfactory system as described by the neural physiology, functional genomics, and genetics underlying the demonstrated changes in the behavioural repertoire in female mosquitoes. The review is meant as a summary introduction to the current conceptual thinking in the field.

show abstract

Genetic technologies for disease vectors

Cited by 10 publications

References 81 publications

Insecticide Resistance and Management Strategies in Urban Ecosystems

Insecticide Resistance and Management Strategies in Urban Ecosystems

Targeted delivery of CRISPR-Cas9 ribonucleoprotein into arthropod ovaries for heritable germline gene editing

Modulation of odour-guided behaviour in mosquitoes

Contact Info

Product

Resources

About