Genetic toxicology of ascorbic acid

Shamberger, Raymond J.

doi:10.1016/0165-1110(84)90005-8

Cited by 145 publications

(53 citation statements)

References 96 publications

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“…However, administration of large amounts of AA to biological systems has lead to genotoxic effects in several different test systems (Shamberger, 1984) because AA has both antioxidant and prooxidant activities (Bijur et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Modulatory effects of the antioxidant ascorbic acid on the direct genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster

2007

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In this study two different crosses involving the wing cell markers mwh and flr 3 (standard (ST) cross and high bioactivation (HB) cross, the latter being characterized by a high constitutive level of cytochrome P450 which leads to an increased sensitivity to a number of promutagens and procarcinogens) were used to investigate the modulatory effects of ascorbic acid (AA) combined with the antitumor agent doxorubicin (DXR) in Drosophila melanogaster. We observed that the two different concentrations of AA (50 or 100 mM) had no effect on spots frequencies, while DXR treatments (0.2 or 0.4 mM) gave positive results for all types of spots, when compared to negative control. For marker-heterozygous (MH) flies, a protective effect was observed with the lower concentration of AA (50 mM) that was able to statistically decrease the frequency of spots induced by DXR (0.2 mM), while an enhanced frequency of spots induced by DXR was observed with the higher concentration of AA (100 mM), when compared to DXR treatment (p < 0.05). These results suggest that AA may interfere with free radicals generated by DXR and with other possible reactive metabolites. The efficiency of AA in protecting the somatic cells of D. melanogaster against mutation and recombination induced by DXR is dependent on the dose used and the protection is directly related to the activity of cytochrome P450 enzymes.

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Section: Introductionmentioning

confidence: 99%

Modulatory effects of the antioxidant ascorbic acid on the direct genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster

2007

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“…Vitamin C (L ascorbic acid) is an excellent antioxidant which can react with and scavenge out many of these free radicals and oxidative products (Shamberger 1984), and thereby protects cells against the genotoxicity of various oxidants (Machlin and Bendich 1987). Fortunately, this vitamin has no genotoxicity of its own (Ghaskadbi andVaidya 1989, Bose and, and is rightly believed to act as a bioantimutagen (kada 1984, Shamberger 1984, Gebhart et al 1985. In most of the previous studies (Hoda andSinha 1991a, b, Hoda et al 1991), the pesticide induced genotoxicity got significantly minimised by the human therapeutic dose of vitamin C (10 mg/kg bw/day), but it (vitamin C) never brought the damage-frequency down to the con trol level.…”

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confidence: 99%

Dose-Dependent Minimisation of Cytogenetic Toxicity of Endosulfan(an Organochlorine Pesticide) by Vitamin C.

Khan

Sinha

1992

CYTOLOGIA

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“…It has been demonstrated that treatment with ascorbic acid (vitamin C) significantly reduced the genotoxicity of well-known mutagens (Cabrera, 2000;Blasiak and Kowalik, 2001;Siddique et al, 2005;Misra and Choudhury, 2006). However, large amounts of ascorbic acid has been reported to cause some genotoxic effects in in vitro test systems (Shamberger, 1984;Nefic, 2008) because ascorbic acid has both antioxidant and pro-oxidant activities (Bijur et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Ascorbic Acid (Vitamin C)-Mediated Protection on Mutagenic Potentials of Cisplatin in Mice Bearing Ascites Dalton ’s Lymphoma

Amenla¹,

Prasad²

2016

Research J. of Mutagenesis

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Cisplatin is a potent anticancer drug which has been in use against a variety of cancers for a long time. The present study was carried out to assess the protective ability of ascorbic acid on cisplatin-induced mutagenic effects in tumor-bearing mice. The increase in the frequency of chromosomal aberrations, micronuclei and sperm abnormality were studied as markers of mutagenicity. Indicators of oxidative stress relatives like lipid peroxidation, reduced glutathione and the activities of enzymes such as catalase, glutathione-S-transferase and glutathione reductase were also studied to understand the possible mechanism(s) underlying this amelioration. Pre-treatment with ascorbic acid in combination group significantly reduced cisplatin-induced mutagenicity, markedly decreased lipid peroxidation along with increased level of glutathione and activities of antioxidant enzymes particularly in the liver of mice. The overall studies suggest that ascorbic acid with its antioxidant and free radical scavenging properties may play a part in its protective role in the abatement of cisplatin-induced mutagenesis and oxidative damage in the normal tissues of mice.

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Genetic toxicology of ascorbic acid

Cited by 145 publications

References 96 publications

Modulatory effects of the antioxidant ascorbic acid on the direct genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster

Modulatory effects of the antioxidant ascorbic acid on the direct genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster

Dose-Dependent Minimisation of Cytogenetic Toxicity of Endosulfan(an Organochlorine Pesticide) by Vitamin C.

Ascorbic Acid (Vitamin C)-Mediated Protection on Mutagenic Potentials of Cisplatin in Mice Bearing Ascites Dalton ’s Lymphoma

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