Genetic toxicology of mitomycin C, actinomycins, daunomycin and adriamycin

Vig, Baldev K.

doi:10.1016/0165-1110(77)90022-7

Cited by 100 publications

(16 citation statements)

References 234 publications

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“…There is also some DNA synthesis during the meiotic prophase (Hotta et al, 1966 ;Kofman-Alfaro and Chandley, 1970) (Di Marco et al, 1971 ;Zunino et al, 1972Zunino et al, , 1975Zunino et al, , 1977. The incorporation of nucleic acid precursors into DNA and RNA are inhibited by this drug, and it has been shown to inhibit mitosis and induce chromosome aberrations and tumors in vivo (Vig, 1971(Vig, , 1977Newsome and Littlefield, 1975 ;Marquardt et al, 1976). In small doses, adriamycin has been demonstrated to have an effect on mitosis and when given in larger amounts, on DNA and RNA (Tobey, 1972 (Kim and Kim, 1972).…”

mentioning

confidence: 99%

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Biochemical studies of the rat seminiferous epithelial wave : DNA and RNA syntheses and effects of adriamycin

Parvinen¹,

Parvinen²

1978

Ann. Biol. anim. Bioch. Biophys.

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mentioning

confidence: 99%

“…In small doses, adriamycin has been demonstrated to have an effect on mitosis and when given in larger amounts, on DNA and RNA (Tobey, 1972 (Kim and Kim, 1972). Although the effects of adriamycin on human and other mammalian chromosomes have been studied (Vig, 1977) …”

mentioning

confidence: 99%

Biochemical studies of the rat seminiferous epithelial wave : DNA and RNA syntheses and effects of adriamycin

Parvinen¹,

Parvinen²

1978

Ann. Biol. anim. Bioch. Biophys.

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“…This chemical is a powerful clastogen in vitro (Vig, 1977), in vivo in mice (Maier and Schmid, 1976;Au and Hsu, 1980) and man (Hacker-Klom et al, 1986). The drug is highly fluorescent (Krishan and Ganapathi, 1980), and when excited with a 350-nm argon laser beam, the emission spectrum (Krishan et al, 1985) is in the same range as the DNA fluorochrome (DAPI) used in the present investigation.…”

Section: Introductionmentioning

confidence: 57%

Alterations in the cellular DNA and protein content determined by flow cytometry as indicators for chemically induced structural and numerical chromosome aberrations

Maier

Schawalder

1988

Mutagenesis

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Cellular DNA and protein content were determined simultaneously in freshly isolated fibroblast-like rat cells by flow cytometry. After exposure to doxorubicin, nitrofurantoin, propranolol and practolol at a low, tissue like oxygen concentration (5% O 2 ), drug-induced alterations in cell cycle kinetics, in the distribution of DNA and in the protein content of G,-phase cells (nucleus/cytoplasm ratio) were analysed. Optimal exposure time (5 or 24 h) and recovery interval (24 or 48 h) were determined. Variation in the exposure time and recovery period can affect cell cycle kinetics both qualitatively and quantitatively, whereas the distribution of DNA and protein content are affected quantitatively only. A 24-h exposure combined with a 24-h recovery period proved to be the most efficient approach. Each of the tested chemicals induced a specific, dose-dependent pattern of altered cellular DNA and protein content. Comparison with results obtained in other genotoxicity tests, and with data reported earlier, showed that this two-parameter protocol can be used to recognize and to characterize chemicals as clastogens, or as compounds with a combined cytostatic/clastogenic activity, or as spindle-poison-like compounds.

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“…Aktinomicin D inhibira sintezu mRNA čime je onemogućena i sinteza proteina (12,21,24). Antraciklinski antibiotici doksorubicin i daunomicin vežu se na dvolančanu molekulu DNA i umetanjem između lanaca remete sintezu i DNA i RNA, inhibiraju DNA-topoizomerazu II, izazivaju dvolančane i jednolančane lomove u DNA te stvaranje slobodnih radikala.…”

Section: Citotoksični Antibiotici I Njima Srodne Tvariunclassified

“…Potiče stvaranje slobodnih radikala i lomova u DNA. Inhibira sintezu i funkciju DNA, a u višim koncentracijama i RNA (12,14,21,24).…”

Section: Citotoksični Antibiotici I Njima Srodne Tvariunclassified

Antineoplastic Drugs as a Potential Risk Factor in Occupational Settings: Mechanisms of Action at the Cell Level, Genotoxic Effects, and Their Detection Using Different Biomarkers

Kopjar

Želježić

Kašuba

et al. 2010

Archives of Industrial Hygiene and Toxicology

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Nevenka KOPJAR, Davor ŽELJEŽIĆ, Vilena KAŠUBA i Ružica ROZGAJ Institut za medicinska istraživanja i medicinu rada, Zagreb, HrvatskaPrimljeno u siječnju 2010. Prihvaćeno u veljači 2010.U članku je prikazana osnovna podjela antineoplastičnih lijekova prema mehanizmima djelovanja na razini stanice. Objašnjeni su mehanizmi genotoksičnosti najvažnijih vrsta lijekova koji se primjenjuju u okviru uobičajenih protokola za liječenje zloćudnih novotvorina. Navedena je važeća klasifi kacija antineoplastika prema kancerogenom potencijalu, podaci o mutagenom potencijalu te je prikazana njihova podjela u skladu s anatomsko-terapijsko-kemijskim sustavom klasifi kacije. Sustavno su prikazani najvažniji rezultati svjetskih i hrvatskih istraživanja na populacijama radnika izloženih antineoplasticima, provedenih u razdoblju 1980.-2009. s pomoću četiri najčešće primjenjivane metode: analize izmjena sestrinskih kromatida, analize kromosomskih aberacija, mikronukleus-testa i komet-testa. Objašnjena su osnovna načela navedenih metoda te raspravljene njihove prednosti i nedostaci. Biološki pokazatelji daju važne podatke o individualnoj osjetljivosti profesionalno izloženih ispitanika koji mogu poslužiti unaprjeđenju postojećih uvjeta rada i upravljanju rizicima pri izloženosti genotoksičnim agensima. Na osnovi prednosti i nedostataka citogenetičkih metoda zaključeno je da je mikronukleus-test, koji podjednako uspješno dokazuje klastogene i aneugene učinke, jedna od najboljih metoda dostupnih za otkrivanje štetnih djelovanja antineoplastičnih lijekova koji su u aktivnoj primjeni.

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Genetic toxicology of mitomycin C, actinomycins, daunomycin and adriamycin

Cited by 100 publications

References 234 publications

Biochemical studies of the rat seminiferous epithelial wave : DNA and RNA syntheses and effects of adriamycin

Biochemical studies of the rat seminiferous epithelial wave : DNA and RNA syntheses and effects of adriamycin

Alterations in the cellular DNA and protein content determined by flow cytometry as indicators for chemically induced structural and numerical chromosome aberrations

Antineoplastic Drugs as a Potential Risk Factor in Occupational Settings: Mechanisms of Action at the Cell Level, Genotoxic Effects, and Their Detection Using Different Biomarkers

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