Genetic Variability and Alzheimer’s Disease

Hardy, John; Mullan, Mike; Crawford, Fiona; Duff, Karen; Crook, Richard; Diaz, P.; Bennett, C. Ray; Houlden, H; Fidani, Liana; Goate, A.; Parfitt, Matthew; Roques, P; Rossor, Martin N.; Chartier‐Harlin, Marie‐Christine

doi:10.1007/978-3-662-01135-5_18

Amyloid Protein Precursor in Development, Aging and Alzheimer’s Disease 1994

DOI: 10.1007/978-3-662-01135-5_18

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Genetic Variability and Alzheimer’s Disease

John Hardy

Mike Mullan²,

Fiona Crawford³

et al.

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Cited by 2 publications

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Transgenic mouse models of Alzheimer's disease: How useful have they been for therapeutic development?

Duff

Suleman

2004

Briefings in Functional Genomics and Proteomics

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Transgenic mice have been created in an attempt to generate models of human Alzheimer's disease, but success has been partial and unpredictable. The overall aim of this paper is to illustrate how genomics can be used in translational research, turning genetic information in the form of pathogenic mutations into clinically useful drugs against a major human disease. This paper will illustrate how genetic information allows researchers to dissect the aetiology of a disease and then replicate the disease in vivo through the process of transgenesis. The limitations of recreating a condition like Alzheimer's disease in a transgenic mouse, how far the mice have advanced understanding of the disease and how useful they have been for the development of therapeutics will then be discussed.

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Transgenic mouse models of Alzheimer's disease: How useful have they been for therapeutic development?

Duff

Suleman

2004

Briefings in Functional Genomics and Proteomics

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Muscarinic M1-Receptor Agonists

Cutler

Sramek

1995

CNS Drugs

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Genetic Variability and Alzheimer’s Disease

Cited by 2 publications

References 46 publications

Transgenic mouse models of Alzheimer's disease: How useful have they been for therapeutic development?

Transgenic mouse models of Alzheimer's disease: How useful have they been for therapeutic development?

Muscarinic M1-Receptor Agonists

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