Genetic variability of human pegivirus type 1 (HPgV-1) among Congolese co-infected with hepatitis C virus in Brazzaville, Congo

Fabien, NIAMA Roch; Mayengue, Pembé Issamou; Cendres, MATONGO NSOUKOULA Bertivie; Félix, KOUKOUIKILA-KOSSOUNDA; Cynthia, NKOUA BADZI; Fred, MANDIANGOU Aldi; Igor, LOUZOLO; Urielle, FILA-FILA Grâce Petula; Régis, DOSSOU-YOVO Louis; Brunel, ANGOUNDA Monic

doi:10.1016/j.ijregi.2023.03.005

Cited by 1 publication

(3 citation statements)

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“…All our samples belonged to the HPgV-1 genotype 2: 67% belonging to subgenotype 2B and 33% belonging to subgenotype 2A. Genotype 2 is a prevalent genotype of HPgV-1, being the most disseminated in Europe and the USA [ 29 , 30 , 31 ]. It is particularly detected among individuals who inject drugs [ 10 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is particularly detected among individuals who inject drugs [ 10 , 32 , 33 ]. Studies performed in Brazil show that in this Latin American country, genotype 2 is dominant [ 9 , 31 , 34 ]; this includes the state of São Paulo [ 34 ]. This might be the reason for the extensive identification of HPgV-1 genotype 2 among the tested patients.…”

Section: Discussionmentioning

confidence: 99%

“…An interesting observation in the phylogenetic tree was that the strains obtained from FH patients clustered together with the reference Brazilian sequences. Such a clustering might be due to a regional HPgV-1 circulation since RNA viruses present local genetic diversification related to a genotype-specific geographic distribution [ 31 , 35 , 36 ]. Therefore, the genotypic distribution observed in our study might have been a reflection of the circulation of the most pronounced genotype in the state and Brazil, which is important for studies connected to viral molecular epidemiology.…”

Section: Discussionmentioning

confidence: 99%

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Human Pegivirus-1 Detection and Genotyping in Brazilian Patients with Fulminant Hepatitis

da Silva,

de Campos,

Villanova

et al. 2023

Pathogens

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Fulminant hepatitis is a severe clinical disease characterized by a marked decline in liver function and encephalopathy. In a previous survey, using metagenomics in a group of 27 patients with this clinical condition, we observed an expressive quantity of reads of the Human pegivirus-1 (HPgV-1). Therefore, the objective of this study was to evaluate the frequency, molecular features, and HPgV-1 circulating genotypes in patients with fulminant hepatitis. After testing the collected plasma samples, we discovered twelve samples (44.4%) that were positive for HPgV-1 RNA (using both real-time and nested PCR). The positive samples presented a mean cycle threshold (Ct) of 28.5 (±7.3). Genotyping assignments revealed that all HPgV-1 positive samples belonged to the HPgV-1 genotype 2 (both subgenotypes 2A and 2B were identified). Although HPgV-1 is considered a commensal virus, little is known regarding its prevalence and genotypes in cases of fulminant hepatitis. More research is needed to understand whether HPgV-1 can be implicated in clinical disorders and infectious diseases.

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