Genetic Variability of Entamoeba histolytica Strains

Abstract

Entamoeba histolytica is pathogenic parasite that causes asymptomatic infection mostly; however, it may also cause invasive intestinal amoebiasis and liver abscess, leading to significant rates of human mortality globally. The clinical outcome of the infection with the parasite is variable and evidence suggested the contribution of genetic diversity within E. histolytica to human disease. The information documented the whole-genome sequence of the E. histolytica reference laboratory strain (HM-1:IMSS) and the development of sophisticated molecular technique potentiate ability to identify strains of E. histolytica that may lead to insights into the population structure, virulence, pathogenesis, clinical outcome of the disease and epidemiology of the organism.